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APAF1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17534194 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17882496 |
Reduced expression of Apaf-1 is associated with colorectal adenocarcinoma |
| 18042457 |
These data point to a role for Apaf-1 as a bona fide tumor suppressor. |
| 17885667 |
These findings suggest that the efflux of K(+) is prerequisite not only for the formation of the apoptosome but also for the downstream apoptotic signal-transduction pathways. |
| 18093951 |
Apaf-1 has a role in regulating cytochrome c induction of apoptosis in brain tumors but not in normal neural tissues |
| 17876870 |
The expression of Apaf-1 gene is low in gastric cancer tissues. Methylation of Apaf-1 gene promoter and LOH in domain of 12q22-23 are the main reasons for the expression and altered expression of Apaf-1 gene. |
| 16951219 |
The promoter hypermethylation of APAF-1 is a marker of aggressive renal cell carcinoma and provides independent prognostic information on disease outcome. |
| 17603079 |
Fas receptor and Apaf-1 were down-regulated in stage III colorectal cancer cell line. |
| 17541304 |
APAF-1 methylation is related to transcriptional activity of EZH2 expression in early-stage tumor disease of the bladder. |
| 14566819 |
AMF regulates expression of Apaf-1 and caspase-9 genes via a complex signaling pathway and indirectly regulates formation of the apoptosome. | →View more information from publications. |
Recent Publications on APAF1: |  |
Sequence Fourier Analysis of a Specific Protein-DNA (RNA) Interaction; an Intermolecular Frequency Symmetry.
Here, we first report that a specific protein-DNA (RNA) interaction... | 3rd November, 2009
| BioFrontier Institute Inc.
| Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1305-7.
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Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein.
BACKGROUND: The serine/threonine protein kinase B (PKB/Akt) is involved in... | 29th October, 2009
| Department of Pharmacology, Daejeon Regional Cancer Center, Cancer
| BMC Cell Biol. 2009 Jul 15;10:53.
DOI Direct Link |
Amyloid fibrillation of human Apaf-1 CARD.
The idea of establishing the amyloid-like fibrillation tendency of pro-... | 22nd September, 2009
| School of Chemistry, University of Hyderabad, Hyderabad 500046, India.
| Biochemistry. 2009 Aug 18;48(32):7656-64.
DOI Direct Link |
MMP-2 downregulation mediates differential regulation of cell death via ErbB-2 in glioma xenografts.
The epidermal growth factor receptor (EGFR) family (also known as the ErbB... | 2nd September, 2009
| Department of Cancer Biology and Pharmacology, University of Illinois
| Int J Oncol. 2009 Aug;35(2):257-63.
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Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway.
We investigated the downstream mechanisms by which chemotherapeutic drugs... | 28th August, 2009
| Department of Internal Medicine IV, Hepatology and Gastroenterology,
| Int J Cancer. 2009 Aug 26.
DOI Direct Link |
→View more research publications. |
APAF1 results (if any) from reagent suppliers | 
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