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APBA1
| Symbol: | APBA1 | | Name(s): | amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | D9S411E, MINT1, X11, X11A, X11ALPHA | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15699037 |
X11alpha and X11beta have roles in beta-amyloid precursor protein processing |
| 12016213 |
Munc18a acts through direct and indirect interactions with X11 proteins and powerfully regulates APP metabolism and Abeta secretion. |
| 12970358 |
human X11alpha inhibits Abeta production and deposition in vivo in the brain in transgenic mice harboring a familial Alzheimer's disease mutant APP that produces increased levels of Abeta. |
| 16413130 |
Mediates exocytosis and decreases beta-amyloid peptide formation in Alzheimer disease. |
| 12849748 |
Coexpression of X11alpha with amyloid protein precursor retarded its maturation, prolonged its half-life, and inhibited amyloid protein precursor, Abeta40, and Abeta42 secretion. |
| 14970211 |
Involvement of X11L in the phosphorylation of APP family proteins in cellular stress and suggest that X11L protein may be . |
Recent Publications on APBA1: |  |
Somatic alterations, metabolizing genes and smoking in rectal cancer.
Cigarette smoking has been identified as a risk factor for rectal cancer.... | 29th May, 2009
| Department of Internal Medicine, University of Utah Health Sciences
| Int J Cancer. 2009 Jul 1;125(1):158-64.
DOI Direct Link |
Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.
Mints/X11s are neuronal adaptor proteins that bind to amyloid-beta... | 10th April, 2009
| Department of Neuroscience, The University of Texas Southwestern Medical
| J Neurosci. 2008 Dec 31;28(53):14392-400.
DOI Direct Link |
X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
X11 and X11-like proteins (X11L) are neuronal adaptor proteins whose... | 13th February, 2009
| Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences,
| J Biol Chem. 2008 Dec 19;283(51):35763-71. Epub 2008 Oct 9.
DOI Direct Link |
NSF, Unc-18-1, dynamin-1 and HSP90 are inclusion body components in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture.
Neuronal intranuclear inclusion disease, a progressive ataxia that may be... | 4th February, 2009
| School of Medical Science, Griffith Institute of Health and Medical
| Acta Neuropathol. 2008 Dec;116(6):603-14. Epub 2008 Oct 3.
DOI Direct Link |
Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.
Neuronal activity has an impact on beta cleavage of amyloid precursor... | 14th November, 2008
| Laboratory for Structural Neuropathology, RIKEN Brain Science Institute,
| J Cell Biol. 2008 Oct 20;183(2):339-52.
DOI Direct Link |
→View more research publications. |
APBA1 results (if any) from reagent suppliers | 
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APBA1 antibody (ab3448) | Abcam
Rabbit polyclonal to APBA1. APBA1 is part of two multimeric complexes, the first containing Munc18-1 and syntaxin 1 and the second being a brain specific ...
http://www.abcam.com/Mint1-antibody-ab3448.html...
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Antibodies to Synaptic Proteins
IgG fraction of antiserum, mouse ... Apba1(319924) rat ... Apba1(83589), rat, mouse, IP, WB, pricing. M3319, Anti-Mint2 antibody produced in rabbit ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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APBA1 proteins and peptides: Neuroscience > Neurology process ...
APBA1 proteins and peptides. ... APBA1 proteins and peptides. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication ...
http://www.abcam.com/index.html?t=159433&pt=2&c=430&ei=&mu=r...
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Cancer Antibodies :: Page 6
APAF1 Antibody, XW-7034, H, M, WB, Apoptotic protease activating factor 1. APBA1 Antibody, 45-260, H, M, R, E, WB, APBA1 / MINT1 ...
http://www.prosci-inc.com/shop/catalog1/Cancer-Antibodies-p-...
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X11α (H-265) Antibody sc-14032
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, APBA1, 320, 9q21.11, NM_001163 ...
http://www.scbt.com/datasheet-14032-x11alpha-h-265-antibody....
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All Cell Type Marker | Abcam
APBA1 peptide. BL. ab52224 · Apoptosis repressor with CARD antibody. WB, ELISA. Images. Rabbit polyclonal. Reacts with: ...
http://www.abcam.com/index.html?c=414...
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X11α (23) Antibody sc-136122
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Apba1, 319924, 19 B, NP_796008 ...
http://www.scbt.com/datasheet-136122-x11alpha-23-antibody.ht...
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