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APBB2
| Symbol: | APBB2 | | Name(s): | amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FE65L, FE65L1, MGC35575 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15714520 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 17567906 |
In response to TNF, Zfra is upregulated and modulates TNF-mediated cell death via interacting with TRADD, FADD and RIP (death-inducing signaling complex) at the receptor level, and downstream effectors NF-kappaB, p53, WOX1, and JNK1. |
| 14527950 |
FE65L1 potentiates gamma-secretase processing of APP CTFs. This requires binding of FE65L1 to APP and APP CTFs. Enhanced APP CTF processing can be detected in early endosome vesicles |
| 16083851 |
the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF |
| 15714520 |
rs13133980 associated significantly with age of onset in Alzheimer disease. Genetic variations in APBB2 may affect late onset AD susceptibility. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | amyloid beta A4 precursor protein-binding, family B, member 2 | amyloid beta A4 protein precursor, isoform a | - | - | Pubmed |
| HPRD | amyloid beta A4 precursor protein-binding, family B, member 2 | amyloid beta A4 protein precursor, isoform a | - | - | Pubmed |
| HPRD | amyloid beta A4 precursor protein-binding, family B, member 2 | amyloid beta precursor-like protein 2 | - | - | Pubmed |
| HPRD | amyloid beta A4 precursor protein-binding, family B, member 2 | amyloid beta precursor-like protein 2 | - | - | Pubmed |
Recent Publications on APBB2: |  |
Expression QTL and regulatory network analysis of microtubule-associated protein tau gene.
Numerous studies have shown that the microtubule-associated protein tau... | 13th October, 2009
| Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong
| Parkinsonism Relat Disord. 2009 Aug;15(7):525-31. Epub 2009 Feb 23.
DOI Direct Link |
Analysis of APBB2 gene polymorphisms in sporadic Alzheimer's disease.
The accumulation of beta-amyloid (Abeta) in the brain plays a central role... | 10th April, 2009
| Department of Molecular Pathology, Medical University of Lodz, 8/10
| Neurosci Lett. 2008 Dec 12;447(2-3):164-6. Epub 2008 Oct 7.
DOI Direct Link |
AICD and its adaptors - in search of new players.
In view of the emerging evidence that amyloid-beta load in the brain and... | 12th October, 2007
| Structural Genomics Section, Saha Institute of Nuclear Physics, 1/AF
| J Alzheimers Dis. 2007 Jun;11(3):343-58.
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Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response.
BACKGROUND: Zfra is a 31-amino-acid zinc finger-like protein, which is... | 1st August, 2007
| Institute of Molecular Medicine, National Cheng Kung University Medical
| BMC Mol Biol. 2007 Jun 13;8:50.
DOI Direct Link |
Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis.
Polymorphic genes associated with Alzheimer's disease (see ) delineate a... | 21st March, 2007
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| Neurochem Int. 2007 Jan;50(1):12-38. Epub 2006 Sep 12.
DOI Direct Link |
→View more research publications. |
APBB2 results (if any) from reagent suppliers | 
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Orbigen Inc. - Orbigen Inc.
Amyloid beta (A4) protein-binding family B member 2 (APBB2) polyclonal antibody ... APBB2 interacts with the beta-amyloid precursor protein and with APLP2 ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...
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Alzheimer's Disease Antibodies :: Page 1
Alzheimer's Disease gamma-Secretase Detection Set, PSI-1820, see datasheet, WB, APH1 (NT), Nicastrin (CT), PEN2 (CT), and Presenilin1. APBB2 Antibody, 49- ...
http://www.prosci-inc.com/shop/catalog1/Alzheimers-Disease-A...
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Genetic Disease Markers
Amyloid beta (A4) protein-binding family B member 2 (APBB2) polyclonal antibody, PAB-10414, $175.00. aryl hydrocarbon receptor (AHR) polyclonal antibody ...
http://www.orbigen.com/dictionary/cat1052.htm...
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Abgent - Cell and Function Antibodies
AT1157aNEW, AP4M1 monoclonal antibody (M01), ELISA,WB-Ce, H. AP6101a, APBB2 Antibody (C-term), WB, E, H. AT1158aNEW, APC monoclonal antibody (M01) ...
http://www.abgent.com/products/category/cell_function...
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Orbigen Inc. - Orbigen Inc.
PAB-10414, Amyloid beta (A4) protein-binding family B member 2 (APBB2) polyclonal antibody · NM_173075, 100 µg, $210.00 ...
http://www.orbigen.com/commerce/catalog/spcategory.jsp?categ...
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Fe65 Antibody / Fe65 Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. Fe65 (E-20) Antibody, sc-19751, goat IgG, N-terminus (h), WB, IP, IF, ELISA, m, r, h ...
http://www.scbt.com/ko/table-fe65.html...
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Abcam antibodies and reagents product map
... AKAP12 antibodies (5) · AKAP12 proteins and peptides (2) · AKAP13 antibodies (3) · AP1M2 antibodies (1) · AP2B1 antibodies (1) · APBB2 antibodies (2) ...
http://www.abcam.com/index.html?cl=2105&pageconfig=productma...
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