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APC


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Gene DB Home
Symbol:APC
Name(s):adenomatous polyposis coli
Type:protein-coding
Organism:Homo sapiens
Synonyms:BTPS2, DP2, DP2.5, DP3, GS
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18027849 investigate the possible role of germline hypermethylation of the APC promoter in FAP and AFAP families that were negative for APC and MUTYH mutations
18199528 Observational study of gene-disease association. (HuGE Navigator)
18343606 Observational study of gene-disease association. (HuGE Navigator)
17963004 study detected 17 different truncating mutations APC in 21 of 24 Chilean familial adenomatous polyposis families; 9 of these were novel
18337602 Methylation of the promoter region of the APC gene in patients with stage I NSCLC treated with curative intent by means of surgery is associated with early recurrence.
18265644 The data support that the frequencies and patterns of somatic mutation othe APC gene in colorectal cancer are variable among different populations.
18058812 No field effect, defined as absence of epigenetically transformed cells, for GSTP1 was observed, whereas APC, RARbeta2, and RASSF1A showed a field effect up to 3 mm from the malignant core in three prostatectomy samples.
11159880 Observational study of genetic testing. (HuGE Navigator)
11221825 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
11241320 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAPCSeven in absentia homolog 1--Pubmed
HPRDAPCaxin 1 isoform a--Pubmed
HPRDAPCaxin 2--Pubmed
HPRDAPCPTK2 protein tyrosine kinase 2 isoform b--Pubmed
HPRDAPCretinitis pigmentosa RP1 protein--Pubmed
HPRDAPCkinesin-associated protein 3--Pubmed
HPRDAPCRho guanine nucleotide exchange factor 4 isoform a--Pubmed
HPRDadenomatosis polyposis colicell division cycle 20--Pubmed
HPRDadenomatosis polyposis colicatenin, beta 1, 88kDa--Pubmed
HPRDadenomatosis polyposis coliMAD2-like 1--Pubmed

Recent Publications on APC:

Pubmed Logo
The oral cancer epidemic in central and eastern Europe.
To monitor recent trends in oral and pharyngeal cancer mortality in 38...
3rd November, 2009
Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy. Int J Cancer. 2009 Oct 30.
DOI Direct Link
CD4(+)CD25(+) Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma japonicum is TLR2 dependent.
Chronic schistosome infection results in the suppression of host immune...
3rd November, 2009
Department of Pathogen Biology & Immunology, Department of Pharmacology, Eur J Immunol. 2009 Oct 30;39(11):3052-3065.
DOI Direct Link
Generation of antigen-presenting cells from tumor-infiltrated CD11b myeloid cells with DNA demethylating agent 5-aza-2'-deoxycytidine.
Tumor-recruited CD11b myeloid cells, including myeloid-derived suppressor...
3rd November, 2009
Department of Urology, Shands Cancer Center, College of Medicine, Cancer Immunol Immunother. 2009 Oct 31.
DOI Direct Link
Bias-free electro-optic polymer-based two-section Y-branch waveguide modulator with 22 dB linearity enhancement.
A bias-free two-section Y-branch directional coupler modulator with high...
3rd November, 2009
Opt Lett. 2009 Nov 1;34(21):3277-3279. doi: 10.1364/OL.34.003277.
Discrete Domains of MARCH1 Mediate Its Localization, Functional Interactions, and Posttranscriptional Control of Expression.
Within APCs, ubiquitination regulates the trafficking of immune modulators...
3rd November, 2009
Department of Immunobiology. J Immunol. 2009 Oct 30.
DOI Direct Link

View more research publications.

Press Releases on APC:

BioPortfolio Logo
APC Overnight Joins Forces With Blue Peter and Operation Smile 22nd October, 2009

LONDON, October 22 /PRNewswire/ -- APC Overnight is helping the BBC TV children's show Blue Peter's Send a Smile Appeal in aid of Operation Smile, which helps to transform the lives of

Alimentary Health's Probiotic Technology Launched Nationwide in the US 12th May, 2009

CORK, Ireland, May 12 /PRNewswire/ -- Alimentary Health Ltd. ("Alimentary Health" or "the Company"), the specialty gastrointestinal company, welcomes today's announcement

Instrumentation Laboratory Wins Patent Infringement and Unfair Competition Trial Against Diagnostica Stago Relating to Reagents for Hemostasis Diagnostics 4th May, 2009 Instrumentation Laboratory Company

- Court Orders Confiscation of Diagnostica Stago's Inventory of Infringing Products -

BEDFORD, Mass., May 4 /PRNewswire/ -- Instrumentation Laboratory Company

Cellectricon and BioFocus DPI Advance High Throughput ion Channel Drug Discovery 27th April, 2009

GOTHENBURG, Sweden, April 27 /PRNewswire/ -- Cellectricon, a leading provider of automated screening solutions for drug discovery, today announced its collaboration with BioFocus DPI, a contract

Technology Leaders Call on Congress to Support Investments in Digital Infrastructure as Part of Economic Stimulus and Recovery Plan 22nd January, 2009 Technology CEO Council

WASHINGTON, Jan. 22 /PRNewswire-USNewswire/ -- Technology and business leaders from over 100 companies today called strategic investments in digital infrastructure a vital

BioNews Results for APC

: RSS Logo
BioPortfolio Logo
The secrets of gut bacteria
Irish Medical News:  Nov 10 2009 4:20PM Matching: apc
First-quarter fiscal 2010 results announced by Rural/Metro
News-Medical.Net:  Nov 9 2009 12:49PM Matching: apc
Cardiome Reports Third Quarter Results
Pharmacy Choice:  Nov 9 2009 9:50PM Matching: apc
Cardiome Reports Third Quarter Results
Pharma Live:  Nov 9 2009 5:29PM Matching: apc
Cardiome Reports Third Quarter Results
Canada NewsWire:  Nov 9 2009 1:57PM Matching: apc
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Study of APC8015F Immunotherapy in Prostate Cancer Patients Who Participated in Study D9902B and Have Experienced Disease Progression and Disease-Related Pain

Patents:

Patents logo
US Patent No.Title
7604841 Method for extending time between chamber cleaning processes
7608259 Methods of cancer diagnosis and therapy targeted against a cancer stem line
7608267 Multifunctional cytokines
7608392 Diagnostic assay for measuring a cell mediated immune response
7608394 Methods and compositions for phenotype identification based on nucleic acid methylation

View more patents.

APC results (if any) from reagent suppliers

Google CSE Logo
APC antibody (ab15270) | Abcam
Rabbit polyclonal to APC. Adenomatous polyposis coli (APC) is a protein that plays a critical role in several cellular processes. APC is a tumor suppressor,
...
http://www.abcam.com/apc-antibody-ab15270.html...

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APC Antibody #2504
APC was immunoprecipitated with APC Antibody (lane 2) or with rabbit IgG (lane 3 ) to confirm specificity. Western blot was detection was performed using APC ...
http://www.cellsignal.com/products/2504.html...

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mouse/human CD45R antibody, Allophycocyanin (APC) conjugate
eBioscience technical data sheet for product 17-0452 APC anti-mouse/human CD45R (B220) RA3-6B2 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_17/17-...

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Mouse antibody IgG2b, kappa [A-1] (APC-CY5.5) (ab46791) | Abcam
Mouse IgG2b, kappa [A-1] (APC-CY5.5) - Isotype Control. ...
http://www.abcam.com/Mouse-antibody-IgG2b-kappa-A-1-APC-CY5-...

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mouse CD25 antibody, Allophycocyanin (APC) conjugate
eBioscience technical data sheet for product 17-0251 APC anti-mouse CD25 ( Interleukin-2 Receptor alpha, IL-2 Receptor alpha, IL-2Ra, p55, IL2Ra) PC61.5
...
http://www.ebioscience.com/ebioscience/specs/antibody_17/17-...

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Monoclonal Antibody to CD207/Langerin (Clone 310F7.02/HD26) APC ...
Monoclonal Antibody to CD207/Langerin (Clone 310F7.02/HD26) APC ... DDX0361APC [ Monoclonal Antibody to CD207/Langerin (Clone 310F7.02/HD26) APC Conjugated] ...
http://www.imgenex.com/antibody_details.php?catalog=DDX0361A...

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mouse CD11c antibody, Allophycocyanin (APC) conjugate
eBioscience technical data sheet for product 17-0114 APC anti-mouse CD11c ( Integrin aX, p150/90) N418 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_17/17-...

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