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APEX1
| Symbol: | APEX1 | | Name(s): | APEX nuclease (multifunctional DNA repair enzyme) 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | APE, APE-1, APE1, APEN, APEX, APX, HAP1, REF-1, REF1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18208837 |
Wild type p53 is a negative regulator of APE1 expression. |
| 18357393 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18324520 |
APE1 regulated PTEN expression is mediated by Egr-1. |
| 18206643 |
Tat-APE1/ref-1 might be useful to reduce vascular endothelial activation or vascular inflammatory disorders |
| 15816625 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15878096 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15887293 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16000577 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16195237 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16221808 |
Meta-analysis and HuGE review of gene-disease association, gene-environment interaction, and healthcare-related. (HuGE Navigator) | →View more information from publications. |
Recent Publications on APEX1: |  |
HIF-1 attenuates Ref-1 expression in endothelial cells: reversal by siRNA and inhibition of geranylgeranylation.
Redox factor-1 (Ref-1), a multifunctional protein with DNA repairing... | 31st October, 2009
| Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics
| Vascul Pharmacol. 2009 Aug-Sep;51(2-3):133-9. Epub 2009 Jun 11.
DOI Direct Link |
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.
The DNA cleavage step in both the class switch recombination (CSR) and... | 23rd October, 2009
| Department of Immunology and Genomic Medicine, Graduate School of
| Int Immunol. 2009 Aug;21(8):947-55. Epub 2009 Jun 25.
DOI Direct Link |
Apex1 can cleave complex clustered DNA lesions in cells.
Current data indicate that clustered DNA damage generated by ionizing... | 6th October, 2009
| Department of Molecular and Cellular Physiology, Louisiana Health Sciences
| DNA Repair (Amst). 2009 Sep 30.
DOI Direct Link |
Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking.
BACKGROUND: Polymorphisms altering DNA repair capacity may lead to... | 25th September, 2009
| Department of Molecular Medicine, Institute for Experimental Medicine
| Anticancer Res. 2009 Jun;29(6):2417-20.
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Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.
Base excision repair (BER) is the major pathway for removing mutagenic and... | 19th September, 2009
| Biomedical Research Center, National Institute on Aging, NIH, Baltimore,
| Mol Cancer Res. 2009 Jun;7(6):897-906. Epub 2009 May 26.
DOI Direct Link |
→View more research publications. |
APEX1 results (if any) from reagent suppliers | 
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APEX1 Antibody (NT) APE1 / APEX1
APEX1 antibody was raised against a synthetic peptide near the N-terminus of APEX1.,
http://www.prosci-inc.com/shop/catalog1/APEX1-Antibody-p-260...
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APEX1 Antibody (N-term)
Western blot analysis of anti-APEX1 Antibody (N-term) (Cat.#AP2849a) in Hela cell line lysates (35ug/lane). APEX1 (arrow) was detected using the purified ...
http://www.abgent.com/products/catalog_no/AP2849a_APEX1_Anti...
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APEX1 antibody - GeneTex Inc. - Your source for monoclonal ...
Product Description, Rabbit polyclonal antibody to APEX1 (APEX nuclease ... Specificity, This antibody is specific to the Human APEX1 protein. ...
http://www.genetex.com/WebPage/Product/ProductDetail.aspx?Ca...
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Anti-APE1 Polyclonal Antibody
PA1-9007 detects APEX1 in human samples. PA1-9007 has been successfully used ... Figure 1 illustrates Western blot detection of APEX1 in A431 lysate using ...
http://www.bioreagents.com/products/productDetails/productDe...
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APE antibody, APE Antibody, Rabbit Polyclonal Antibody
Rabbit polyclonal to APE; 328; APEX1; 107748; P27695; APE; APE1; APEN; APEX; APX ; HAP1; REF-1; REF1;; DNA-(apurinic or apyrimidinic site) lyase, APEX1_HUMAN ...
http://www.genwaybio.com/product_info.php?products_id=196003...
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A2105 Monoclonal Anti-AP Endonuclease antibody produced in mouse ...
Synonym: Anti-AP lysase, Anti-APE/Ref1, Anti-APE1, Anti-APEN, Anti-APEX nuclease , Anti-APEX1, Anti-Apurinic/Apyrimidinic Endonuclease, Anti-HAP1 ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A210...
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Cell Cycle(293) - GeneTex Inc. - Your source for monoclonal ...
APEX1 antibody (APEX nuclease (multifunctional DNA repair enzyme) 1), GTX100050, Rabbit PAb, WB, 100 μl, USD $269.00, -. APEX1 antibody ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...
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