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HES1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16894395 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17388915 |
expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia |
| 17822320 |
Overexpression of hes1 is associated with breast cancer |
| 12972610 |
Hes1 transcription repression activity is inhibited by Hes6. |
| 16365048 |
Notch protein binding to Hes5-GFP is extinguished fast and recovered slowly, whereas Hes1-GFP is inhibited late and recovered quickly |
| 12406868 |
HES-1 preserves the long-term reconstituting hematopoietic activity of 34-KSL stem cells ex vivo. |
| 12535671 |
These results indicate that the molecular association between HES1-, HEY2- and SIRT1-related proteins is conserved among metazoans, from Drosophila to human, and suggest that the Sir2-bHLH interaction also plays important roles in human cells. |
| 15536134 |
IkappaBalpha is recruited to the promoter regions of the Notch-target gene, hes1 |
| 15563463 |
Notch1 inhibits the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through HES1 |
| 16253247 |
HES-1 is an upstream negative regulator of REST expression. | →View more information from publications. |
Recent Publications on HES1: |  |
Oncogenic BRAFv600einduces expression of neuronal differentiation marker map2 in melanoma cells by promoter demethylation and downregulation of transcription repressor HES1.
MAP2 is a neuron-specific microtubule associated protein that binds and... | 3rd November, 2009
| University of Wisconsin-Madison, United States.
| J Biol Chem. 2009 Oct 30.
DOI Direct Link |
Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina.
Vertebrate retinal progenitor cells (RPCs) are pluripotent, but pass... | 31st October, 2009
| Division of Developmental Biology, Cincinnati Children's Research
| J Neurosci. 2009 Oct 14;29(41):12865-77.
DOI Direct Link |
Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia.
Hairy enhancer of split 1 (Hes1) is a basic helix-loop-helix... | 29th October, 2009
| Department of Cell Therapy and Transplantation Medicine, Graduate School
| Blood. 2009 Oct 27.
DOI Direct Link |
Tumour necrosis factor-alpha impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1.
Tumour necrosis factor-alpha (TNFalpha) is a pro-inflammatory cytokine,... | 21st October, 2009
| Department of Anatomy and Neuroscience, University College Cork, Ireland.
| Mol Cell Neurosci. 2009 Oct 17.
DOI Direct Link |
Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells.
BACKGROUND: Barrett's esophagus (BE) is the predominant risk factor for... | 15th October, 2009
| Department of Surgery, University of Rochester Medical Center, Rochester,
| Surgery. 2009 Oct;146(4):714-21; discussion 721-2.
DOI Direct Link |
→View more research publications. |
HES1 results (if any) from reagent suppliers | 
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