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BIRC2


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Symbol:BIRC2
Name(s):baculoviral IAP repeat-containing 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:API1, HIAP2, Hiap-2, MIHB, RNF48, cIAP1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17822677 Importantly, our findings suggest that a paradox exists whereby Nrf2 activity is beneficial in non-malignant cells but in cancer cells it may provide a selective advantage for clonal expansion.
17626072 Bortezomib inhibited expression of cIAP-1, cIAP-2, and XIAP, which are regulated by NF-kappaB and function as inhibitors of apoptosis.
12651874 cIAP1 and cIAP2 are potential oncogenes and are overexpressed in multiple lung cancers with or without higher copy numbers
16080516 There is endogenous cLAP1 expression in MKN45 cells, which may be a factor in the presumed anti-apoptotic system in these human gastric cancer cells.
15911110 nuclear cIAP-1 expression appears to be a useful marker for predicting poor prognosis in head and neck squamous cell carcinoma (HNSCC), and may play roles in HNSCCs through the signaling pathway mediated by Smac/DIABLO and caspase-3
15187025 c-IAP1 cellular location has a role in regulating cell differentiation
16701639 Results indicate a novel mechanism by which HIAP2 can regulate ER-initiated apoptosis by modulating the activity of caspase-2.
14960576 levels of c-IAP1 and c-IAP2 are regulated by Smac/DIABLO through the ubiquitin/proteasome pathway
14960583 HIAP2 is translationally induced during endoplasmic reticulum stress
15501771 expression in urethral epithelium upregulated by Neisseria gonorrhoeae PorB IB and upregulation dependent on NF-kappaB activation

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDApoptosis inhibitor 1caspase 9 isoform alpha preproprotein--Pubmed
HPRDHIAP2caspase 9 isoform alpha preproprotein--Pubmed
HPRDHIAP2caspase 3 preproprotein--Pubmed
HPRDHIAP2TNF receptor-associated factor 1--Pubmed
HPRDHIAP2HtrA serine peptidase 2 isoform 1 preproprotein--Pubmed
HPRDHIAP2TNF receptor-associated factor 2--Pubmed
HPRDApoptosis inhibitor 1caspase 7 isoform delta--Pubmed
HPRDHIAP2caspase 7 isoform delta--Pubmed
HPRDbaculoviral IAP repeat-containing protein 2TRAF2--Pubmed
HPRDbaculoviral IAP repeat-containing protein 2TRAF1--Pubmed

Recent Publications on BIRC2:

Pubmed Logo
Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action.
BACKGROUND: Garlic or Allium sativum (As) shows therapeutic effects such...
12th September, 2009
Unite de recherche n 01/UR/08-07, Faculte de Medecine, Tunis, Tunisie. Reprod Biol Endocrinol. 2009 Jun 24;7:65.
DOI Direct Link
The role of survivin in the resistance of endometriotic stromal cells to drug-induced apoptosis.
BACKGROUND Decreased susceptibility of endometrial tissue to apoptosis may...
5th September, 2009
Department of Obstetrics and Gynecology, Tottori University Faculty of Hum Reprod. 2009 Sep 3.
DOI Direct Link
cIAP proteins: keystones in NOD receptor signal transduction.
NOD1 and 2 are intracellular sentinels critical to innate immunity. In...
18th July, 2009
Campbell Family Cancer Research Institute, Princess Margaret Hospital, Immunity. 2009 Jun 19;30(6):755-6.
DOI Direct Link
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.
Cellular inhibitor of apoptosis proteins (cIAPs) block apoptosis, but...
18th July, 2009
Montreal Neurological Institute, McGill University, Montreal, Quebec, Immunity. 2009 Jun 19;30(6):789-801. Epub 2009 May 21.
DOI Direct Link
MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression.
Osteosarcoma is the primary malignant cancer of bone and particularly...
14th May, 2009
Department of Molecular Virology and Microbiology, Baylor College of Cancer Res. 2009 Mar 15;69(6):2559-67. Epub 2009 Mar 10.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7560537 Human sarcoma-associated antigens
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6960439 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6964850 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

BIRC2 results (if any) from reagent suppliers

Google CSE Logo
BIRC2 antibody, Baculoviral IAP repeat-containing protein 2 ...
Buy quality rabbit BIRC2 antibody (interacts with human), anti-BIRC2, Baculoviral IAP repeat-containing protein 2 antibody, rabbit polyclonal antibody
, ...
http://www.genwaybio.com/product_info.php?products_id=15190...

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Purified Anti-Bcl10 Antibody - BioLegend
Regulation: Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Interaction: MALT1, TRAF2, Caspase-9, BIRC2/c-IAP2. Antigen ...
http://www.biolegend.com/purified-anti-bcl10-antibody-5122.h...

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TNFRSF1B antibody, TNF-RECEPTOR II (p75/p80) Antibody, Rat IgG2a ...
The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of ...
http://www.genwaybio.com/product_info.php?products_id=175021...

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c-IAP1 (N-19) Antibody sc-1867
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, BIRC2, 329, 11q22.2, NM_001166 ...
http://www.scbt.com/datasheet-1867-c-iap1-n-19-antibody.html...

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Antibody Products - IgG Polyclonal Antibodies - GenWay
BIRC2; API1; IAP2; MIHB; HIAP2; RNF48 - Inhibitor of apoptosis protein 2; HIAP2; HIAP-2; C-IAP1; TNFR2-TRAF signaling complex protein 2; IAP homolog B; ...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=B...

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Panorama® Antibody Array - Signal Transduction
BIRC2. baculoviral IAP repeat-containing 2. 329 · BIRC3. baculoviral IAP repeat- containing protein 3. 330 · BIRC5. baculoviral IAP repeat-containing 5 ...
http://www.sigmaaldrich.com/life-science/cell-biology/protei...

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IAP Antibody / IAP Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. c-IAP1/2 (A-13 ) Antibody, sc-12410, goat IgG, N-terminus (h), WB, IP, IF, ELISA, m, r, h ...
http://www.scbt.com/table-iap.html...

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