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HSPA1A


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Symbol:HSPA1A
Name(s):heat shock 70kDa protein 1A
Type:protein-coding
Organism:Homo sapiens
Synonyms:HSP70-1, HSP70-1A, HSP72, HSPA1, HSPA1B
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18299791 Observational study of gene-disease association. (HuGE Navigator)
18166694 main finding of this study was the down-regulation of Hsp72 as well as the protective effect against oxidative damage accumulation in relatively higher levels of physical activity during aging
12082592 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
12687213 Observational study of gene-disease association. (HuGE Navigator)
14501185 Observational study of gene-disease association. (HuGE Navigator)
14605873 Observational study of gene-disease association. (HuGE Navigator)
15079808 Observational study of gene-disease association. (HuGE Navigator)
15165109 Observational study of gene-disease association. (HuGE Navigator)
15190186 Observational study of gene-disease association. (HuGE Navigator)
15232679 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDapoptotic peptidase activating factor 1 isoform cheat shock 70kDa protein 1A--Pubmed
HPRDapoptotic peptidase activating factor 1 isoform cheat shock 70kDa protein 1A--Pubmed
HPRDAPEX nucleaseheat shock 70kDa protein 1A--Pubmed
HPRDAPEX nucleaseheat shock 70kDa protein 1A--Pubmed
HPRDApolipoprotein Bheat shock 70kDa protein 1A--Pubmed
HPRDapolipoprotein B precursorHeat shock 70 KD protein 1A--Pubmed
HPRDB-cell lymphoma protein 2 alpha isoformHeat shock 70 KD protein 1A--Pubmed
HPRDcyclin-dependent kinase 9Heat shock 70 KD protein 1A--Pubmed
HPRDNAD(P)H menadione oxidoreductase 1, dioxin-inducible isoform aheat shock 70kDa protein 1A--Pubmed
HPRDNAD(P)H menadione oxidoreductase 1, dioxin-inducible isoform aheat shock 70kDa protein 1A--Pubmed

Recent Publications on HSPA1A:

Pubmed Logo
Heat-shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer and the outcome of surgical treatment.
BACKGROUND: Foot ulcer is a significant cause of morbidity in diabetics....
30th October, 2009
Department of Surgical Endocrinology, Christian Medical College, Vellore, Br J Surg. 2009 Oct;96(10):1205-9.
DOI Direct Link
Interactive association of heat shock protein 70 genes variants with natural longevity in Xinjiang Hetian Uygur ethnicity.
Mounting evidence suggests that all organisms at the cellular level...
21st October, 2009
Cardiology Department, The First Affiliated Hospital of Xinjiang Medical Transl Res. 2009 Nov;154(5):257-64. Epub 2009 Sep 4.
DOI Direct Link
Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies.
Heat shock proteins (Hsps) are ubiquitous and phylogenetically conserved...
13th October, 2009
First Department of Obstetrics and Gynecology, Semmelweis University, Cell Stress Chaperones. 2009 Oct 12.
DOI Direct Link
Deficit of heat shock transcription factor 1-heat shock 70 kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 6.
Spinocerebellar ataxia type 6 (SCA6) is caused by a small expansion of...
13th October, 2009
Department of Pharmacology and Neurobiology, Graduate School of Medicine, Genes Cells. 2009 Oct 8.
DOI Direct Link
The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells.
The differentiated epidermis of human skin serves as an essential barrier...
8th October, 2009
Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cell Stress Chaperones. 2009 Oct 7.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7611893 Metal-binding therapeutic peptides
7415358 Molecular toxicology modeling
7384964 Synthesis of epothilones, intermediates thereto, analogues and uses thereof
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

HSPA1A results (if any) from reagent suppliers

Google CSE Logo
HSPA1A Antibody
Specific antibody for the gene product of HSPA1A, the protein Heat shock 70kDa protein 1A. Validated for specificity by gene-silencing with siRNA followed ...
http://www.piercenet.com/products/browse.cfm?fldID=D3597660-...

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HSPA1A/HSPA1B Antibody (Y525)
Western blot analysis of HSPA1A (arrow) using rabbit polyclonal HSPA1A Antibody (S525) (Cat.#AP7574c). 293 cell lysates (2 ug/lane) either nontransfected ...
http://www.abgent.com/products/catalog_no/AP7574c_HSPA1A_HSP...

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HSP 70/HSC 70 (W27) Antibody sc-24
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, HSPA1A, 3303, 6p21.33, NM_005345 ...
http://www.scbt.com/datasheet-24-HSP-70-HSC-70-w27-antibody....

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Phospho-HSPA1A-pY41 Antibody
Dot blot analysis of anti-HSPA1A-pY41 Phospho-specific Pab (Cat.#AP3419a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot
...
http://www.abgent.com/products/catalog_no/AP3419a_Phospho_HS...

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H5147 Monoclonal Anti-Heat Shock Protein 70 antibody produced in ...
isotype, IgG1. Gene Information, human ... HSPA1A(3303), HSPA1B(3304). rat ... Hspa1a(24472), Hspa1b(294254). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=H514...

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Protein Modification - Ubiquitination Antibody
AP7574c, HSPA1A/HSPA1B Antibody (Y525), WB, E, H. AT2444aNEW, HSPA1B monoclonal antibody (M02), ELISA,IF,IHC-P,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/protein_modification...

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Antibodies to Chaperonins and Heat Shock Proteins
Hspa1a(24472), Hspa1b(294254), bovine, guinea pig, plant, human, nematode, rabbit, Drosophila, rat, hamster, chicken, ARR, ELISA (i), EM, IHC (f), WB ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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