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l(2)gl


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Symbol:l(2)gl
Name(s):lethal (2) giant larvae
Type:protein-coding
Organism:Drosophila melanogaster
Synonyms:CG2671, D-LGL, LGL, dlgl, gl, l(2), l(2) giant larva, l(2)giant larvae, l-gl, l[[2]]gl, p127, p127l(2)gl
Links: Pubmed, Entrez Gene, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17870065 lgl- clones in the larval eye disc exhibit ectopic expression of the G1-S regulator, Cyclin E, and ectopic proliferation, but do not lose apico-basal cell polarity.
17369850 aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia
17352292 The loss of one dose of tumor suppressor lgl+ provided for increased survival rate and life span of lgl/+ heterozygotes under stress conditions.
15901829 hitherto unreported role for Lgl as a regulator of Sanpodo during asymmetric cell division in the adult peripheral nervous system
12629552 The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.
15916953 Lgl regulates cell fate by controlling Partner-of-Numb cortical localization, asymmetric localization of Numb and Neuralized, and plasma-membrane localization of Sandopo.
16357871 Clonal analysis in larval brains showed that pins mutant neuroblasts rapidly fail to self-renew, whereas lethal giant larvae (lgl) mutant neuroblasts generate multiple neuroblasts
16251968 Lgl associates with Dishevelled, an essential mediator of Wnt signalling, and that Dishevelled regulates the localization of Lgl in Xenopus ectoderm and Drosophila follicular epithelium

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDSyntaxin 4 CG2715-PA [Drosophila melanogaster].lethal giant larvae CG2671-PA, isoform A [Drosophila melanogaster].Lgl interacts with Syntaxin4. This interaction was modeled on a demonstrated interaction between Drosophila Lgl and Syntaxin4 from an unspecified species.-Pubmed
BINDpar-6 CG5884-PB, isoform B [Drosophila melanogaster].lethal giant larvae CG2671-PA, isoform A [Drosophila melanogaster].Par-6 interacts with Lgl.-Pubmed
BINDlethal giant larvae CG2671-PA, isoform A [Drosophila melanogaster].-Lgl interacts with an unspecified isoform of Myosin II.-Pubmed
BINDlethal giant larvae CG2671-PA, isoform A [Drosophila melanogaster].atypical protein kinase C CG10261-PA, isoform A [Drosophila melanogaster].aPKC phosphorylates Lgl.-Pubmed

l(2)gl results (if any) from reagent suppliers

Google CSE Logo
mouse GL7 antibody, Affinity Purified conjugate
The GL-7 (GL7) antibody has been reported for use in flow cytometric analysis, immunoprecipitation, ... serving as a preferred ligand for CD22/Siglec-2. J Biol
Chem. ... Hathcock, K.S., C.E.M. Pucillo, G. Laszlo, L. Lai, and R.J. Hodes. ...
http://www.ebioscience.com/ebioscience/specs/antibody_14/14-...

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MAPK1 antibody, Phospho-p44/42 MAPK (ERK1/2 Antibody, Rabbit ...
2) Johnson G L and Lapadat R (Johnson, G.L. Lapadat, R. 2002) Science, 298, 1911 -1912 3) Kolch, W. (2000) Biochem. J. 351, 289-305 ...
http://www.genwaybio.com/product_info.php?products_id=283037...

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mouse GL7 antibody, Biotin conjugate
13-4341) (open histogram) or 0.25 μg of Biotin GL-7 (GL7) (colored histogram) ... on bone marrow pre-B-II cells, germinal center B cells, and also human B
cell lines ... Hathcock, K.S., C.E.M. Pucillo, G. Laszlo, L. Lai, and R.J. Hodes
. ...
http://www.ebioscience.com/ebioscience/specs/antibody_13/13-...

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GFRa-2 Antibody
2. Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B,. Vandlen R, Simmons L, Gu Q, Hongo JA, Devaux B, Poulsen K,. Armanini M, Nozaki C, Asai N,
...
http://www.prosci-inc.com/shop/pdf/1135.pdf...

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CD115 antibody, CD115 Antibody, Rat Monoclonal Antibody
Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ... 2. Gilmore. G.L. et al. (1995) Inhibition of day-12 spleen ...
http://www.genwaybio.com/product_info.php?products_id=310191...

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mouse gamma delta TCR antibody, Phycoerythrin-Cy5 (PE-Cy5) conjugate
This GL3 (GL-3) antibody has been reported for use in flow cytometric analysis. ... Selective expression of CD8a (Ly-2) subunit on activated thymic γδ cells.
... LeFrançois, L. 1991. Phenotypic complexity of intraepithelial lymphocytes
...
http://www.ebioscience.com/ebioscience/specs/antibody_15/15-...

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Other Antibody References
Li JL, Shen GL, Ghetie MA, May RD, Till M, Ghetie V, Uhr JW, Janossy G, Thorpe PE, ... II. Expression of Tac antigen on activated cytotoxic killer T cells,
.... Lappi DA, Esch FS, Barbieri L, Stirpe F, Soria M (1985) Characterization of
...
http://www.atsbio.com/reference/ab.html...

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