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BIRC5


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Symbol:BIRC5
Name(s):baculoviral IAP repeat-containing 5 (survivin)
Type:protein-coding
Organism:Homo sapiens
Synonyms:API4, EPR-1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18154598 Our findings suggest an important role of survivin to promote trophoblast cell survival and proliferation during placentation, thus maintaining pregnancy.
18057009 survivin in the cell nucleus has reduced stability and is not cytoprotective
18027854 expression is negatively regulated by Egr-1
18206228 Observational study of gene-disease association. (HuGE Navigator)
18334114 Observational study of gene-disease association. (HuGE Navigator)
18181175 Up-regulation of of BIRC5 is associated with breast carcinomas
18171482 Survivin and VEGF co-expression is an independent prognostic survival factor for patients with advanced nasopharyngeal carcinoma.
17098350 Survivin gene RNAi not only could inhibit the proliferation of human cervical carcinoma cells (HeLa), but also could enhance the radiosensitivity of those cells. RNAi-targeted survivin gene strategy is an approach to radiosensitization therapy
18069771 Survivin may play an important role in progression of hepatocellular carcinoma by promoting cell proliferation, and may be positively correlated with high risk of disease recurrence and poor prognosis.
18242580 identify leptin/STAT3 signaling as a novel pathway for survivin expression in breast cancer cells

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDSurvivincyclin-dependent kinase 4--Pubmed
HPRDSurvivincaspase 9 isoform alpha preproprotein--Pubmed
HPRDSurvivincell division cycle 2 protein isoform 1--Pubmed
HPRDSurvivincaspase 3 preproprotein--Pubmed
HPRDSurvivindiablo isoform 1 precursor--Pubmed
HPRDSurvivincaspase 7 isoform delta--Pubmed
HPRDbaculoviral IAP repeat-containing protein 5Caspase 3--Pubmed
HPRDbaculoviral IAP repeat-containing protein 5Caspase 7--Pubmed
HPRDbaculoviral IAP repeat-containing protein 5Cyclin dependent kinase 4--Pubmed
HPRDbaculoviral IAP repeat-containing protein 5Caspase 9--Pubmed

Recent Publications on BIRC5:

Pubmed Logo
Upregulated p27kip1 can downregulate survivin expression and inhibit telomerase activity in gastric carcinoma cells.
Previous study indicated that p27kip1 gene transfer can obviously inhibit...
30th October, 2009
Department of Gastroenterology, Taihe Hospital, Yunyang Medical College, Cancer Invest. 2009 Nov;27(9):898-900.
Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma.
AIM: To investigate whether peroxisome proliferator-activated receptor...
29th October, 2009
Department of Pathology, The First Affiliated Hospital of Inner Mongolia World J Gastroenterol. 2009 Aug 21;15(31):3874-83.
Regulation of survivin and Bcl-2 in HepG2 cell apoptosis induced by quercetin.
Quercetin, a widely distributed bioflavonoid, has been shown to induce...
27th October, 2009
Bioengineering College, Chongqing University, Chongqing, P. R. China. Chem Biodivers. 2009 Jul;6(7):1101-10.
DOI Direct Link
Survivin and its spliced isoform gene expression is associated with proliferation of renal cancer cells and clinical stage of renal cancer.
BACKGROUND: Survivin has been implicated in inhibition of apoptosis. To...
21st October, 2009
Department of Urology, Gunma University Graduate School of Medicine, Cancer Epidemiol. 2009 Aug;33(2):137-41.
DOI Direct Link
Lupeol triterpene, a novel diet-based microtubule targeting agent: disrupts survivin/cFLIP activation in prostate cancer cells.
Recently we showed Lupeol, a triterpene, found in fruits and vegetables...
14th October, 2009
School of Medicine and Public Health, University of Wisconsin, 1300 Biochem Biophys Res Commun. 2009 Oct 23;388(3):576-82. Epub 2009 Aug 14.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Survivin Peptide Vaccination for Patients With Advanced Melanoma, Pancreatic, Colon and Cervical Cancer

Patents:

Patents logo
US Patent No.Title
7608707 siRNA targeting survivin
6960439 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6964850 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6995244 Antagonists for human prolactin
7081340 Gene expression profiling in biopsied tumor tissues

View more patents.

BIRC5 results (if any) from reagent suppliers

Google CSE Logo
BIRC5 antibody, Baculoviral IAP repeat-containing protein 5 ...
Buy quality rabbit BIRC5 antibody (interacts with mouse), anti-BIRC5, Baculoviral IAP repeat-containing protein 5 antibody, rabbit polyclonal antibody
, ...
http://www.genwaybio.com/product_info.php?products_id=15084...

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BIRC5 Antibody
Specific antibody for the gene product of BIRC5, the protein Baculoviral IAP repeat-containing protein 5. Validated for specificity by gene-silencing with
...
http://www.piercenet.com/products/Browse.cfm?fldID=ADEEA5F7-...

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Baculoviral IAP repeat-containing 5 (BIRC5) polyclonal antibody ...
KLH conjugated synthetic peptide comprised of amino acids 323 - 337 [ IRSGVQRSPPRRASS] of the human Baculoviral IAP repeat-containing 5 (BIRC5)
protein. ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

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Purified Anti-Survivin Antibody - BioLegend
Purified Anti-Survivin Antibody - Survivin (also known as baculoviral IAP repeat -containing protein (BIRC5)) is a member of the IAP family containing a BIR ...
http://www.biolegend.com/purified-anti-survivin-antibody-214...

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p-Survivin (Thr 34) Antibody sc-16320
Human, BIRC5, 332, 17q25.3, NM_001012270, NM_001012271, NM_001168 · O15392 · 603352. Mouse, Birc5, 11799, 11 E2, O70201 ...
http://www.scbt.com/datasheet-16320-p-survivin-thr-34-antibo...

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Antibody Products - IgG Polyclonal Antibodies - GenWay
BIRC5; API4; IAP4 - Apoptosis inhibitor survivin; Apoptosis inhibitor 4; Baculoviral IAP repeat-containing protein 5 isoform 3, IgG Polyclonal ...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=B...

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survivin (C-19) Antibody sc-8807
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, BIRC5, 332, 17q25.3, NM_001012270, ...
http://www.scbt.com/datasheet-8807-survivin-c-19-antibody.ht...

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