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APLP2
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17452623 |
YWK-II (APLP2 protein) is a G(o)-coupled receptor for Mullerian inhibiting substance in mediating ERK1/2 activation leading to anti-apoptotic activity or cell survival. |
| 16645641 |
findings show an increase in the immunoreactivities for the nuclear C-terminal fragments of APLP2 and for GSK-3beta in the brains of Alzheimer disease patients |
| 17405931 |
APLP2 and APP have roles in sperm function |
| 16279945 |
APLP2 is shed by disintegrins and metalloproteinases. Overexpression of secretase or TACE in HEK293 cells increases the release of neurotrophic soluble APLP2 severalfold. |
| 12228233 |
APLP1 and APLP2 are processed by the gamma-secretase in a Presenilin 1-dependent manner and the extreme carboxyl-terminal fragments produced by this processing (APP-like Intracellular Domain are able to enhance Fe65-dependent gene activation |
| 14597230 |
Sustained levels of APP and the elevated levels of APLP2, in spite of the reduced mRNA expression, are due to altered proteolytic processing of these proteins. |
| 14699153 |
APLP1 and APLP2 and APP are processed similarly to act via the same nuclear target and are regulated by BACE 1 in neurons |
| 14970212 |
APLP-1 and APLP-2 are processed by alpha- and gamma-secretase-like cleavages, and their intracellular domains can be released by cleavage at epsilon-sites. APLP-2 processing appears to be the most elaborate and to involve alternative cleavage sites. |
| 15208260 |
The APLP2 gene has no CAGA box, but it does have a GAGA sequence in a location similar to that of the CAGA box in the APP gene. |
| 15584916 |
Interaction of human and murine Abeta peptides, Abeta40 and Abeta42. Interspecies Abeta aggregates and fibres are readily formed and are more stable than homogenous human fibres. (Amyloid beta 40 and 42) | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | amyloid beta A4 precursor protein-binding, family B, member 1 isoform E9 | amyloid beta precursor-like protein 2 | - | - | Pubmed |
| HPRD | amyloid beta A4 precursor protein-binding, family B, member 2 | amyloid beta precursor-like protein 2 | - | - | Pubmed |
| HPRD | amyloid beta A4 precursor protein-binding, family B, member 2 | amyloid beta precursor-like protein 2 | - | - | Pubmed |
| HPRD | Amyloid precursor like protein 2 | disabled homolog 1 | - | - | Pubmed |
| HPRD | amyloid beta precursor-like protein 2 | DAB1 | - | - | Pubmed |
| HPRD | amyloid beta precursor-like protein 2 | amyloid beta precursor protein-binding, family B, member 3 isoform d | - | - | Pubmed |
| HPRD | amyloid beta precursor-like protein 2 | amyloid beta precursor protein-binding, family B, member 3 isoform d | - | - | Pubmed |
Recent Publications on APLP2: |  |
An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of APP compared to its effect on APLP1.
Inhibition of gamma-secretase cleavage of the amyloid precursor protein... | 14th October, 2009
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| Biochemistry. 2009 Oct 12.
DOI Direct Link |
Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation.
Earlier studies have demonstrated interaction of the murine major... | 8th October, 2009
| UNMC, United States.
| J Biol Chem. 2009 Oct 6.
DOI Direct Link |
Amyloid precursor-like protein 2 association with HLA class I molecules.
Amyloid precursor-like protein 2 (APLP2) is a ubiquitously expressed... | 1st August, 2009
| Eppley Institute for Research in Cancer and Allied Diseases, University of
| Cancer Immunol Immunother. 2009 Sep;58(9):1419-31. Epub 2009 Jan 31.
DOI Direct Link |
Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors.
The Alzheimer's amyloid precursor protein (APP) belongs to a conserved... | 30th July, 2009
| Department of Neurochemistry, Stockholm University, Stockholm, Sweden.
| Cell Mol Life Sci. 2009 Jul;66(14):2299-318. Epub 2009 Mar 31.
DOI Direct Link |
BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.
Alzheimer disease (AD) is characterized by senile plaques, which are... | 14th July, 2009
| Department of Microbiology & Immunology, Albert Einstein College of
| J Biol Chem. 2009 Jun 5;284(23):15815-25. Epub 2009 Apr 14.
DOI Direct Link |
→View more research publications. |
APLP2 results (if any) from reagent suppliers | 
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APLP2 antibody (ab58583) | Abcam
Rabbit polyclonal to APLP2. APLP2 may play a role in the regulation of hemostasis. It may interact with cellular G-protein signaling pathways. ...
http://www.abcam.com/APLP2-antibody-ab58583.html...
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APLP2 (V-20) Antibody sc-23821
goat polyclonal IgG, 200 µg/ml; epitope mapping within an extracellular domain of APLP2 of human origin; recommended for detection of APLP2 of m, ...
http://www.scbt.com/datasheet-23821-aplp2-v-20-antibody.html...
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Mouse APLP-2 Affinity Purified Polyclonal Ab
Mouse APLP-2 specific IgG was purified by mouse APLP-2 affinity chromatography. Mouse APLP-2 is a 120-170 kDa (695 aa) member of the APP ...
http://www.rndsystems.com/pdf/AF3685.pdf...
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APLP2 siRNA (h) sc-41909
Click here for details. suitable control antibody: APLP2 (V-20): sc-23821; sqRT- PCR Primer also available: APLP2 (h)-PR: sc-41909-PR, 20 µl ...
http://www.scbt.com/datasheet-41909-aplp2-sirna-h.html...
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monoclonal antibody template
3 Apr 2008 ... APLP-2 forms both homodimers and heterodimers with APP and APLP-1. Proteolytic cleavage of APLP-2 generates peptides similar to the ...
http://www.rndsystems.com/pdf/MAB4945.pdf...
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APLP2 antibodies: Neuroscience > Neurology process ...
APLP2 antibodies. ... APLP2 antibody. IHC-P, IP, WB, ICC/IF, IHC-Fr. Rabbit polyclonal. Reacts with: Hu, Ms, Rat. Terms and conditions · Legal ...
http://www.abcam.com/index.html?t=224643&pt=1&c=430&ei=&mu=r...
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APLP Antibody / APLP Antibodies
APLP2 (C-17) Antibody, sc-23822, goat IgG, extracellular (h), WB, IF, ELISA, m, r, h. APLP2 (V-20) Antibody, sc-23821, goat IgG, extracellular (h), WB, IF, ...
http://www.scbt.com/table-aplp.html...
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