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HTR2A


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Symbol:HTR2A
Name(s):5-hydroxytryptamine (serotonin) receptor 2A
Type:protein-coding
Organism:Homo sapiens
Synonyms:5-HT2A, HTR2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17899021 These results suggest a progressive reduction of cortical 5-HT(2A)R density as a surrogate biological measure of increased risk for schizophrenia, irrespective of conversion.
17956758 Long-term estrogen replacement therapy in postmenopausal women may be associated with lower 5-HT(2A) receptor availability in hippocampus.
18182772 Our findings support a contribution of the 5-HT(2A) gene to susceptibility to heroin dependence, as well as a possible synergistic effect of 5-HT(2A) and 5-HTT genes on susceptibility to heroin dependence.
18197272 Observational study of gene-disease association. (HuGE Navigator)
18198266 Observational study of gene-disease association. (HuGE Navigator)
18215653 Observational study of genetic testing. (HuGE Navigator)
18241316 Observational study of gene-disease association. (HuGE Navigator)
18247315 Observational study of genotype prevalence. (HuGE Navigator)
18253134 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18270970 Observational study of genotype prevalence. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDpostsynaptic density protein 955-hydroxytryptamine receptor 2A--Pubmed
HPRDpostsynaptic density protein 955-hydroxytryptamine receptor 2A--Pubmed
HPRDGuanine nucleotide binding protein, alpha 115-hydroxytryptamine receptor 2A--Pubmed
HPRDguanine nucleotide binding protein, alpha 11Serotonin 5-HT-2A receptor--Pubmed
HPRDG protein, alpha inhibiting 15-hydroxytryptamine receptor 2A--Pubmed
HPRDguanine nucleotide binding protein, alpha inhibiting activity polypeptide 1Serotonin 5-HT-2A receptor--Pubmed
HPRDGuanine nucleotide binding protein G(q) alpha subunit5-hydroxytryptamine receptor 2A--Pubmed
HPRDguanine nucleotide binding protein, q polypeptideSerotonin 5-HT-2A receptor--Pubmed
HPRDSerotonin 5-HT-2A receptorJanus kinase 2--Pubmed
HPRD5-hydroxytryptamine receptor 2AJanus kinase 2--Pubmed

Recent Publications on HTR2A:

Pubmed Logo
Pharmacogenetics studies in STAR*D: strengths, limitations, and results.
Several lines of evidence support an important genetic contribution to the...
3rd November, 2009
Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Psychiatr Serv. 2009 Nov;60(11):1446-57.
DOI Direct Link
Polymorphisms in serotonin-related genes in anorexia nervosa. The first study in czech population and metaanalyses with previously performed studies.
Anorexia nervosa is a serious psychiatric disorder characterized by the...
30th October, 2009
Charles University in Prague, First Faculty of Medicine: Department of Folia Biol (Praha). 2009;55(5):192-7.
No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample.
Polymorphisms within the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes...
30th October, 2009
Section of Clinical Pharmacology, Department of Neurosciences "B.B. Psychiatry Res. 2009 Sep 30;169(2):164-6. Epub 2009 Jul 31.
DOI Direct Link
Serotonin receptor 2A gene polymorphisms and schizophrenia: association with family history, diagnostic subtype and height in patients.
OBJECTIVES: The 102T/C single nucleotide polymorphism (SNP) in the...
27th October, 2009
Department of Molecular Medicine and Surgery, Karolinska Institute, Neuro Endocrinol Lett. 2009 Aug 26;30(3):343-351.
[Serotonin receptor (5-HTR2A) and dysbindin (DTNBP1) genes and component process variables of short-term verbal memory in schizophrenia]
An association study of variations in the DTNBP1 (P1763 and P1578) and...
21st October, 2009
Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(7):70-5.

View more research publications.

Clinical Trials:

Clinical Trials Logo
Neurobiological and Neurocognitive Disturbances in First-Episode Schizophrenia

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
6955873 Diagnosis and treatment system for reward deficiency syndrome (RDS) and related behaviors
7083921 Method to determine the risk for side effects of an SSRI treatment in a person
7097976 Methods of analysis of allelic imbalance
7202026 Identification of a large number of biological (micro)organisms groups at different levels by their detection on a same array

View more patents.

HTR2A results (if any) from reagent suppliers

Google CSE Logo
Anti-OMI (Htr2A) (CT)
Antibodies , Primary Antibodies , Apoptosis , Autophagy , Anti-OMI (Htr2A) (CT); Host: rabbit polyclonal; Species Reactivity: human; Application: WB, IHC, ...
http://www.anaspec.com/products/product.asp?id=36753...

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OMI Antibody IAP inhibitor
Additional Names. OMI, Htr2A. OMI Antibody. Description. Left: Western blot analysis of OMI in human colon cell lysates with OMI antibody at (A) 0.5 and (B)
...
http://www.prosci-inc.com/shop/catalog1/OMI-Antibody-p-6209....

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SR-2A (A-15) Antibody sc-15073
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, HTR2A, 3356, 13q14.2, NM_000621 ...
http://www.scbt.com/datasheet-15073-sr-2a-a-15-antibody.html...

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Cell-Based GPCR Reporter Assays
HTR2A, Early Access†, Ca²+(Fluo-4). Serotonin, HTR2C, K1877, Ca²+(Fluo-4). Serotonin, HTR2C, Early Access†, Ca²+(Fluo-4). Serotonin, HTR4, PDF Download ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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SR Antibody / SR Antibodies - Santa Cruz Biotechnology, Inc.
製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. SR-1A (A-13) 抗体, sc-32550, goat IgG, C-terminal (h), WB, IF, ELISA, h > m, r, ...
http://www.scbt.com/ja/table-sr.html...

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SelectScreen® Cell-based GPCR Profiling Services
Serotonin, HTR2A, U2OS. Serotonin, HTR2B, NFAT-bla CHO-K1. Serotonin, HTR7, CRE- bla CHO-K1. Somatostatin, SSTR1, U2OS. Somatostatin, SSTR2, U2OS ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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SR-2A (L-20) Antibody sc-32537
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, HTR2A, 3356, 13q14.2, NM_000621 ...
http://www.scbt.com/ja/datasheet-32537-sr-2a-l-20-antibody.h...

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