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IBSP
| Symbol: | IBSP | | Name(s): | integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | BNSP, BSP, BSP-II, SP-II | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18302613 |
has an angiogenic capacity; important in the differentiation of osteoblasts, bone matrix mineralization and tumor metastasis [review] |
| 17956871 |
Runx2 and HDAC3 repress BSP gene expression and that this repression is suspended upon osteoblastic cell differentiation. |
| 16995818 |
Bone sialoprotein is involved in migration of bone marrow stromal cells through Matrigel and collagen barriers. |
| 17213971 |
May be a prognostic marker for bone metastasis in breast cancer. |
| 14524533 |
BSP is expressed in breast and prostate cancer and has a role as a stimulator of bone mineralisation |
| 15795688 |
The time course of the expression of BSP wss visualized after dental implnt implatation in mandibular bone fibroblasts. |
| 17050866 |
bone sialoprotein expression in the primary resected NSCLC is strongly associated with BM progression and could be useful in identifying high-risk patients who could benefit from novel modalities of surveillance and preventive treatment |
| 11968014 |
RT-PCR analysis of human bone marrow stromal cells during osteogenesis in vitro: the mRNA levels of bone morphogenetic protein-2 (BMP-2), bone sialoprotein-II (BSP), osteopontin (OP) and cbfa-1 increased with culture time in osteogenic medium. |
| 16000302 |
Data show that RUNX2 is a direct regulator of bone sialoprotein in osteoblasts and that it functions in cooperation with DLX5 or a related factor to activate osteoblast-specific gene expression. |
| 11979972 |
has RGD sequence, affinity to collagen, and induces mineral crystal formation | →View more information from publications. |
Recent Publications on IBSP: |  |
MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human Unrestricted Somatic Stem Cells (USSCs).
Unrestricted somatic stem cells (USSCs) have been recently identified in... | 3rd October, 2009
| Radboud University Nijmegen Medical Center, Nijmegen, Netherlands;
| Stem Cells Dev. 2009 Oct 1.
DOI Direct Link |
A microarray based identification of osteoporosis-related genes in primary culture of human osteoblasts.
Genetic factors influencing the pathogenesis of osteoporosis are still... | 29th September, 2009
| Chair of Clinical Biochemistry, Faculty of Pharmacy, University of
| Bone. 2009 Sep 23.
DOI Direct Link |
Regulation of bone development and extracellular matrix protein genes by RUNX2.
RUNX2 is a multifunctional transcription factor that controls skeletal... | 4th August, 2009
| Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki
| Cell Tissue Res. 2009 Aug 1.
DOI Direct Link |
Regulation of bone formation and remodeling by G-protein-coupled receptor 48.
G-protein-coupled receptor (GPCR) 48 (Gpr48; Lgr4), a newly discovered... | 17th July, 2009
| The Institute of Biomedical Sciences and School of Life Sciences, East
| Development. 2009 Aug;136(16):2747-56. Epub 2009 Jul 15.
DOI Direct Link |
Differentiation-Dependent Association of Phosphorylated Extracellular Signal-Regulated Kinase with the Chromatin of Osteoblast-Related Genes.
Abstract The ERK/MAP kinase pathway is an important regulator of gene... | 8th July, 2009
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| J Bone Miner Res. 2009 Jul 6.
DOI Direct Link |
→View more research publications. |
IBSP results (if any) from reagent suppliers | 
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