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ICAM3


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Symbol:ICAM3
Name(s):intercellular adhesion molecule 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD50, CDW50, ICAM-R
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18261116 This is the first case of CD20 positive mycosis fungoides involving a lymph node to be reported in the literature.
17570115 Observational study of gene-disease association. (HuGE Navigator)
17913807 Here we demonstrate that leukocyte function-associated antigen 1 (LFA-1), intercellular adhesion molecule 1 (ICAM-1), and ICAM-3 are enriched at the VS and that inhibition of these interactions influences conjugate formation and reduces VS assembly.
17591777 talin induced an intermediate affinity alphaLbeta2 that adhered constitutively to its ligand intercellular adhesion molecule ICAM-1 but not ICAM-3.
17570115 Patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels and lower total white blood cell counts.
12571844 Expression of DC-SIGN and its ligand, ICAM-3, is found in substantial amounts only in RA synovium, suggesting that their interaction is implicated in the additional activation of synovial macrophages that leads to the production of EMMPRIN and MMP-1.
17145745 The results suggest that ICAM-3 assists in the interaction of granulocytes with DC-SIGN of dendritic cells.
11799126 identification of DC-SIGN binding sites
11784723 A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting
14704632 Relationship of intercellular adhesion molecule-3 and hepatocyte growth factor with amyloidosis A in chronic renal-failure patients. There was a higher density of intercellular adhesion molecule-3-positive cells in the patients with amyloidosis A.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDIntercellular adhesion molecule 3unnamed protein product--Pubmed
HPRDIntercellular adhesion molecule 3CD209 molecule--Pubmed
HPRDintercellular adhesion molecule 3 precursorCD209 antigen--Pubmed
HPRDintercellular adhesion molecule 3 precursorintegrin beta chain, beta 2 precursor--Pubmed
HPRDintercellular adhesion molecule 3 precursorintegrin beta chain, beta 2 precursor--Pubmed
HPRDintercellular adhesion molecule 3 precursorintegrin alpha L precursor--Pubmed
HPRDintercellular adhesion molecule 3 precursorintegrin alpha L precursor--Pubmed
HPRDintercellular adhesion molecule 3 precursormoesin--Pubmed
HPRDintercellular adhesion molecule 3 precursormoesin--Pubmed
HPRDintercellular adhesion molecule 3 precursorezrin--Pubmed

Recent Publications on ICAM3:

Pubmed Logo
Transcriptional profiles during the differentiation and maturation of monocyte-derived dendritic cells, analyzed using focused microarrays.
Dendritic cells (DC) are professional antigen-presenting cells capable of...
15th October, 2009
Institute of Biotechnology and Clinical Immunology Research Laboratory of Cell Mol Biol Lett. 2009;14(4):587-608. Epub 2009 Jun 25.
DOI Direct Link
Ovarian cancer-derived glycodelin impairs in vitro dendritic cell maturation.
Local immunosuppressive mechanisms shape the tumor microenvironment and...
9th October, 2009
Department of Obstetrics and Gynecology, Ludwig-Maximilians University, J Immunother. 2009 Jun;32(5):492-7.
DOI Direct Link
HLA and Other Gene Associations with Dengue Disease Severity.
Large case control gene association studies have been performed on cohorts...
6th October, 2009
Centre for Nephrology & The Anthony Nolan Trust, University College Curr Top Microbiol Immunol. 2010;338:99-114.
DOI Direct Link
N-linked glycans on dengue viruses grown in mammalian and insect cells.
This study compared the ability of mosquito and mammalian cell-derived...
25th September, 2009
Department of Microbiology, University of North Carolina School of J Gen Virol. 2009 Sep;90(Pt 9):2097-106. Epub 2009 Jun 3.
DOI Direct Link
Human milk oligosaccharides reduce HIV-1-gp120 binding to dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN).
Breast-feeding is the predominant postnatal transmission route for HIV-1...
18th September, 2009
Department of Microbiology, Immunology and Molecular Genetics, University Br J Nutr. 2009 Feb;101(4):482-6.

View more research publications.

Patents:

Patents logo
US Patent No.Title
6107461 Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
7335761 Avian gene expression controlling regions
7351582 Cell lines
7355008 Identification and engineering of antibodies with variant Fc regions and methods of using same
7361740 Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis

View more patents.

ICAM3 results (if any) from reagent suppliers

Google CSE Logo
ICAM Antibody / ICAM Antibodies
ICAM-3 (101-1D2) Antibody, sc-21776, mouse IgG2a, FL (h), FCM, human. ICAM-3 ( 186.2G9) Antibody, sc-65269, mouse IgG2b, FL (h), WB, IP, IF, IHC(P), FCM ...
http://www.scbt.com/table-icam.html...

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PerCP/Cy55 Anti-human CD50 ICAM-3 Antibody Anti-CD50 - BioLegend
PerCP/Cy55 Anti-human CD50 ICAM-3 Antibody Anti-CD50 - CD50 is a 120-140 kD type I membrane protein also known as intercellular adhesion molecule 3 ...
http://www.biolegend.com/percp-cy55-anti-human-cd50-icam-3-a...

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ICAM-3 (2Q700) Antibody sc-71306
ICAM-3 (2Q700) FITC, sc-71306 FITC, 100 tests in 2 ml ... Western blot analysis of ICAM-3 expression in U-937 (A) and Jurkat (B) whole cell lysates. ...
http://www.scbt.com/datasheet-71306-icam-3-2q700-antibody.ht...

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ICAM3 antibodies: Immunology > Cell Type Markers > CD > Adhesion ...
ICAM3 antibodies. ... ICAM3 antibody [MEM-04]. Flow Cyt, FuncS. Mouse monoclonal ... ICAM3 antibody [MEM-171] (Biotin). Flow Cyt, IP. Mouse monoclonal ...
http://www.abcam.com/index.html?t=7766&pt=1&c=3290&ei=&mu=ra...

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ICAM-3 (By44) Antibody sc-53337
ICAM-3 (By44): sc-53337. Indirect FCM analysis of human peripheral blood ... Western blot analysis of ICAM-3 expression in human PBL whole cell lysate. ...
http://www.scbt.com/datasheet-53337-icam-3-by44-antibody.htm...

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Chemokines Induce Moesin Interaction with ICAM-3 - R&D Systems
The interaction of moesin with ICAM-3 in T lymphocytes was found to be mediated through the intracellular region of ICAM-3, and it was correlated with the ...
http://www.rndsystems.com/cb_detail_objectname_SP98_Chemokin...

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ICAM-3 (CG106) Antibody sc-53338
ICAM-3 (CG106) FITC, sc-53338 FITC, 100 tests in 2 ml ... ICAM-3 (CG106): sc- 53338. Western blot analysis of ICAM-3 expression in HL-60 (A), Jurkat (B), ...
http://www.scbt.com/datasheet-53338-icam-3-cg106-antibody.ht...

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