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ID3


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Symbol:ID3
Name(s):inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Type:protein-coding
Organism:Homo sapiens
Synonyms:HEIR-1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15583422 Observational study of gene-disease association. (HuGE Navigator)
15370294 Fluvastatin did not regulate p21 and p27, but down-regulated Id3 and p53 slightly.
15494533 Overexpression of Id3 enhances expression of ICAM-1 and E-selectin, and induces angiogenic processes such as transmigration, matrix metalloproteinase-2 and -9 expression, and tube formation in cultured vascular endothelial cells.
16449966 ultraviolet radiation-induced apoptosis of immortalized keratinocytes is at least in part due to Id3 upregulation in these cells
17537403 PLZF upregulates apoptosis-inducer TP53INP1, ID1, and ID3 genes, and downregulates the apoptosis-inhibitor TERT gene
15645115 Id1, 2 and 3 might play a role in the early stages of hepatocarcinogenesis, but not in the development of advanced carcinoma, and might consequently be related to HCC dedifferentiation
16682435 ID proteins (ID1, ID2, ID3 and ID4) were significantly increased in Mecp2-deficient Rett syndrome brain; ID genes are ideal targets for MeCP2 regulation of neuronal maturation that may explain the molecular pathogenesis of Rett syndrome
16271072 Id1, 3 double-knockdown significantly impaired the ability of gastric cancer cells to form peritoneal metastasis
12952978 nuclear Id protein acts by sequestering pools of transiently diffusing bHLH protein to prevent reassociation with chromatin domains

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDInhibitor of DNA binding 3myogenic differentiation 1--Pubmed
HPRDInhibitor of DNA binding 3transcription factor 4 isoform b--Pubmed
HPRDInhibitor of DNA binding 3transcription factor 3--Pubmed
HPRDInhibitor of DNA binding 3sterol regulatory element binding transcription factor 1 isoform b--Pubmed
HPRDInhibitor of DNA binding 3myogenic factor 5--Pubmed
HPRDInhibitor of DNA binding 3general transcription factor IIA, 1-like isoform 1--Pubmed
HPRDinhibitor of DNA binding 3TF2A alpha/beta like factor--Pubmed
HPRDinhibitor of DNA binding 3Myogenic differentiation antigen 1--Pubmed
HPRDinhibitor of DNA binding 3Transcription factor 3--Pubmed
HPRDinhibitor of DNA binding 3Transcription factor 4--Pubmed

Recent Publications on ID3:

Pubmed Logo
Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specification.
A complex set of extracellular signals is required for neural crest (NC)...
24th October, 2009
Laboratoire d'Embryologie Moleculaire, Institut de Biologie et de Medecine EMBO J. 2009 Oct 22.
DOI Direct Link
Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.
alphabeta and gammadelta T cells arise from a common thymocyte progenitor...
17th October, 2009
Blood Cell Development and Cancer Keystone, Immune Cell Development and Immunity. 2009 Oct 16;31(4):565-75.
DOI Direct Link
Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells.
Pax7 is a key regulator of skeletal muscle stem cells and is required...
14th October, 2009
Department of Biological Chemistry and Molecular Pharmacology, Harvard Mol Biol Cell. 2009 Jul;20(14):3170-7. Epub 2009 May 20.
DOI Direct Link
Quantitative Transcription Factor Analysis of Undifferentiated Single Human Embryonic Stem Cells.
BACKGROUND: Human embryonic stem cells (hESCs) require expression of...
10th October, 2009
Lundberg Laboratory for Cancer, Department of Pathology, Sahlgrenska Clin Chem. 2009 Oct 8.
DOI Direct Link
Id proteins facilitate self renewal and proliferation of neural stem cells.
Members of helix-loop-helix (HLH) protein family of Id (inhibitor of...
18th September, 2009
School of Medicine, Ajou University, Department of Anatomy, Suwon, Korea, Stem Cells Dev. 2009 Sep 16.
DOI Direct Link

View more research publications.

BioNews Results for ID3

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BioPortfolio Logo
Medical News: Fox Chase Researchers Uncover Process That Determines The Fate Of White Blood Cells
Medical News Today:  Oct 17 2009 10:38AM Matching: id3
Fox Chase Researchers Uncover Process That Determines The Fate Of White Blood Cells
Medical News Today:  Oct 17 2009 8:07AM Matching: id3
ID3 provides career counseling for blood progenitors, driving the creation of gamma-delta T cells
Genetic Engineering News:  Oct 15 2009 5:29PM Matching: id3

Patents:

Patents logo
US Patent No.Title
7548252 Optical scanning apparatus and color image forming apparatus using the same
7565294 Methods and systems employing digital content
7565327 Copyright detection and protection system and method
7568322 Floor covering and laying methods
7569493 Nitride-based compound semiconductor, method of cleaning a compound semiconductor, method of producing the same, and substrate

View more patents.

ID3 results (if any) from reagent suppliers

Google CSE Logo
ID3 antibody [2B11] (ab36501) | Abcam
Mouse monoclonal [2B11] to ID3. ID3 is a member of the Id family of helix-loop- helix proteins. Id proteins are believed to be dominant negative regulators ...
http://www.abcam.com/ID3-antibody-2B11-ab36501.html...

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Id3 (C-20) Antibody sc-490
See how others have used Id3 (C-20): sc-490 antibody and or Id3 (C-20) antibody ... Id3 induces a caspase-3- and -9-dependent apoptosis and mediates UVB ...
http://www.scbt.com/datasheet-490-id3-c-20-antibody.html...

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ID3 antibodies: Stem Cells > Signaling Pathways > TGF beta ...
ID3 antibodies. ... ID3 antibody [2B11]. IP, WB, ICC/IF. Mouse monoclonal. Reacts with: Hu, Ms. ab36501 · ID3 antibody [2B11]. IP, WB, ICC/IF ...
http://www.abcam.com/index.html?t=9120&pt=1&c=3520&ei=&mu=ra...

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Id Antibody / Id Antibodies
Id3 (2B11) Antibody, sc-56712, mouse IgG1, 1-119 (m), WB, IP, IF, m, h ... Id3 ( C-20) Antibody, sc-490, rabbit IgG, C-terminus (h), WB, IF, ELISA, m, r, h, ...
http://www.scbt.com/table-id.html...

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Embryonic Stem Cell Biology Antibodies
WH0003399M1, Monoclonal Anti-ID3 antibody produced in mouse clone 4G1, purified immunoglobulin, buffered aqueous solution, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Bax (ID3) Antibody sc-56010
Bax (ID3) Antibody sc-56010 Bax (ID3) Antibody sc-56010. ... home » Tumor Suppressors/Apoptosis » Bax Antibody / Bax Antibodies » Bax (ID3): sc-56010 ...
http://www.scbt.com/datasheet-56010-bax-id3-antibody.html...

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Monoclonal Antibody to Noxa Biotin Conjugate
Id3 induces a caspase-3- and -9-dependent apoptosis and mediates UVB ... IMGENEX antibodies cited: NOXA (IMG-349A) [WB, Fig 8B (Id3 transfected keratinocyte ...
http://www.imgenex.com/tds/IMG-349B.pdf...

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