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IDH1


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Gene DB Home
Symbol:IDH1
Name(s):isocitrate dehydrogenase 1 (NADP+), soluble
Type:protein-coding
Organism:Homo sapiens
Synonyms:IDH, IDP, PICD
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12923220 IDH1 activity is coordinately regulated with the cholesterol and fatty acid biosynthetic pathways and suggest that it is the source for the cytosolic NADPH required by these pathways
15936593 loss of IDPc and Prx-II during tumor development may involve in tumor progression and metastasis

Recent Publications on IDH1:

Pubmed Logo
IDH1 and IDH2 hotspot mutations are not found in canine glioma.
Objectives: To define the outcome of a cohort of canine patients with a...
31st October, 2009
The Preston Robert Tisch Brain Tumor Center and The Pediatric Brain Tumor Int J Cancer. 2009 Oct 29.
DOI Direct Link
Advances in the genetics of glioblastoma: are we reaching critical mass?
Glioblastoma is the most common and highest-grade brain tumor, causing...
27th October, 2009
Neuro-Oncology Division, Neurology Department, University of Virginia, Nat Rev Neurol. 2009 Aug;5(8):419-26. Epub 2009 Jul 14.
DOI Direct Link
GFAP, Ki67 and IDH1: perhaps the golden triad of glioma immunohistochemistry.
Objectives: To define the outcome of a cohort of canine patients with a...
23rd October, 2009
Institute of Neuropathology, University Hospital Munster, Domagkstr. 19, Acta Neuropathol. 2009 Oct 22.
DOI Direct Link
A monoclonal antibody IMab-1 specifically recognizes IDH1(R132H), the most common glioma-derived mutation.
IDH1 (isocitrate dehydrogenase 1) mutations have been identified as early...
13th October, 2009
Department of Pathology, Duke University Medical Center, DUMC-3156, Biochem Biophys Res Commun. 2009 Oct 7.
DOI Direct Link
Analysis of IDH1 and IDH2 mutations in Japanese glioma patients.
A recent study reported on mutations in the active site of the isocitrate...
10th October, 2009
Department of Neurosurgery, Tohoku University Graduate School of Medicine, Cancer Sci. 2009 Oct;100(10):1996-8.
DOI Direct Link

View more research publications.

BioNews Results for IDH1

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BioPortfolio Logo
Two Gene Mutations Linked to Most Common Brain Cancers - 2/19/09
Johns Hopkins Medicine:  Oct 16 2009 8:17PM Matching: idh1
Two Gene Mutations Linked to Most Common Brain Cancers - 2/19/09
Johns Hopkins Medicine:  Oct 16 2009 8:16PM Matching: idh1

Patents:

Patents logo
US Patent No.Title
6355867 Inbred corn plant 87ATD2 and seeds thereof
6452076 Inbred corn plant 7180 and seeds thereof
6455764 Inbred corn plant WQDS7 and seeds thereof
6459022 Plants and seeds of corn variety I465837
6469235 Inbred corn plant 3327 and seeds thereof

View more patents.

IDH1 results (if any) from reagent suppliers

Google CSE Logo
IDH1 Antibody #3997
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide (KLH-coupled) corresponding to residues near the N terminus of human
IDH1. ...
http://www.cellsignal.com/products/3997.html...

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IDH1 Antibody (Center)
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with IDH1 antibody (Center), which was peroxidase-conjugated to the secondary ...
http://www.abgent.com/products/catalog_no/AP7454c_IDH1_Antib...

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IDH1 Antibody
enous levels of total IDH1 protein. The antibody does not cross react with IDH2. ... of human IDH1. Antibodies were purified by protein A and ...
http://www.cellsignal.com/pdf/3997.pdf...

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IDH1 Antibody (N-term)
Western blot analysis of IDH1 antibody (N-term) (Cat.#AP7454a) in mouse liver tissue lysates (35ug/lane). IDH1 (arrow) was detected using the purified Pab.
...
http://www.abgent.com/products/catalog_no/AP7454a_IDH1_Antib...

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FabGennix Inc. International >> Products
The IDH1 and IDH2 require nicotinamide adeninedinucleotide phosphate (NADP) as ... The identification of mutations in a specific isoform of IDH1 gene in ...
http://www.fabgennix.com/prod_details.asp?myproduct=IDH1%20(...

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IDHC (N-20) Antibody sc-49996
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, IDH1, 3417, 2q33.3, NM_005896 ...
http://www.scbt.com/datasheet-49996-idhc-n-20-antibody.html...

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HA tag antibody (ab13834) | Abcam
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro Oncol 11:341-7 (2009). WB. PubMed: 19435942 ...
http://www.abcam.com/HA-tag-antibody-ab13834.html...

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