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IFI16


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Symbol:IFI16
Name(s):interferon, gamma-inducible protein 16
Type:protein-coding
Organism:Homo sapiens
Synonyms:IFNGIP1, MGC9466, PYHIN2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18231640 WT1 induction led to strong induction of IFI16 expression and its promoter activity was responsive to the WT1 protein.
17699163 IFI16 is a novel regulator of endothelial proinflammatory activity
17981541 IFI16 is involved in DNA damage signaling and cell cycle checkpoint [review]
17981542 loss of IFI16 activates p53 checkpoint through NBS1-DNA-PKcs pathway
17981596 Ifi204 is a regulator of monocyte/macrophage differentiation and make possible a connection with other myeloid regulators [review]
17981573 IFI16 protein has roles in human cancers and autoimmune diseases
17510972 IFI16 appears to be involved in maintaining the normal growth of epithelial cells, whereas its downregulation may contribute to uncontrolled cell proliferation and tumorigenesis.
12894224 increased levels of IFI 16 in prostate epithelial cells contribute to senescence-associated irreversible cell growth arrest.
16494870 IFI16 protein bound to androgen receptor (AR) in a ligand-dependent manner and the DNA-binding domain of the AR was sufficient to bind IFI16.
14990579 IFI16 has a role in activation of p53 induced by ionizing radiation

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDInterferon gamma inducible protein 16tumor protein p53--Pubmed
HPRDinterferon, gamma-inducible protein 16p53--Pubmed

Recent Publications on IFI16:

Pubmed Logo
Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR.
HIN200 is a human IFN-inducible gene and homologous to murine IFI202 gene,...
19th September, 2009
Medical Microbiology Interdisciplinary Program, Graduate School, Lupus. 2009 Oct;18(12):1066-72.
DOI Direct Link
Activation of the interferon-induced STAT pathway during an adenovirus type 12 infection.
We have previously described a temporal regulation of host cell gene...
18th September, 2009
Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden. Virology. 2009 Sep 30;392(2):186-95. Epub 2009 Aug 8.
DOI Direct Link
Expression of the interferon-inducible proteins MxA and IFI16 in liver allografts.
AIMS: To test the hypothesis that the activation of the interferon (IFN)...
29th July, 2009
DPMSC, Medical Liver Transplantation Unit, University of Udine, Udine, Histopathology. 2009 Jun;54(7):837-46.
DOI Direct Link
In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16.
The Interferon-inducible gene, IFI16 has been implicated in the control of...
26th June, 2009
Department of Public Health and Microbiology, Medical School of Turin, Via Cancer Lett. 2009 Jun 22.
DOI Direct Link
IFI16 and NM23 bind to a common DNA fragment both in the P53 and the cMYC gene promoters.
In the melanoma M14 cell line, we found that the antimetastatic protein...
11th June, 2009
Dipartimento di Scienze Biochimiche A Rossi Fanelli, Sapienza Universita J Cell Biochem. 2009 Mar 1;106(4):666-72.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
6818401 Method of detection and interpretation of mutations through expression or function tests of haploid genes
6953691 Nucleic acid molecule encoding a PANG6 polypeptide
6960439 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6964850 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles

View more patents.

IFI16 results (if any) from reagent suppliers

Google CSE Logo
IFI16 antibody (ab55328) | Abcam
Mouse monoclonal to IFI16. Interferon (IFN) Inducible 16 (IFI16) protein belongs to a family of HIN 200 human and mouse proteins. IFI16 is a nuclear protein ...
http://www.abcam.com/IFI16-antibody-ab55328.html...

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I1659 Monoclonal Anti-IFI-16 antibody produced in mouse ~1 mg/mL ...
I1659 Monoclonal Anti-IFI-16 antibody produced in mouse ~1mg/mL, clone IFI-230, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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IFI-16 (1G7) Antibody sc-8023
See how others have used IFI-16 (1G7): sc-8023 antibody and or IFI-16 (1G7) ... Western blot analysis of IFI-16 expression in non-transfected: sc-110760 (A) ...
http://www.scbt.com/datasheet-8023-ifi-16-1g7-antibody.html...

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Monoclonal Anti-IFI-16 antibody produced in mouse (I1659) - Datasheet
Monoclonal Anti-IFI-16 (mouse IgG1 isotype) is derived from the IFI-230 hybridoma produced by ... IFI-16 expression in hematopoietic cells of the
myeloid ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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IFI-16 (C-18) Antibody sc-6050
IFI-16 (C-18): sc-6050. Indirect, intracellular FCM analysis of fixed and ... Western blot analysis of IFI-16 expression in non-transfected: sc-110760 (A) ...
http://www.scbt.com/datasheet-6050-ifi-16-c-18-antibody.html...

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IFI16 antibodies: Cell Biology > Cell Cycle > Cell Cycle ...
IFI16 antibodies. ... IFI16 antibody [IFI-230]. IP, WB, ELISA, ICC/IF. Images. Mouse monoclonal. Reacts with: Hu. Terms and conditions · Legal ...
http://www.abcam.com/index.html?t=202282&pt=1&c=270&ei=&mu=r...

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IFI-16 (1G7) Antibody sc-8023
IFI-16 (1G7): sc-8023 antibody 및 IFI-16 (1G7) antibody conjugates를 사용한 ... Western blot analysis of IFI-16 expression in non-transfected: sc-110760 (A) ...
http://www.scbt.com/ko/datasheet-8023-ifi-16-1g7-antibody.ht...

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