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cdc2


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Symbol:cdc2
Name(s):cdc2
Type:protein-coding
Organism:Drosophila melanogaster
Synonyms:CDC2, CDCDm, CDK1, CDK1/CDC2, CG5363, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, cdc, cdc2Dm, group 4, l(2)31Eh
Links: Pubmed, Entrez Gene, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17519285 These results show that the two potential Cdk1 phosphorylation sites on Drosophila Cdc27 are required for its chromosomal localisation during mitosis and imply that these localisations specific to Cdc27 are crucial for APC/C functions.
12820955 CDK1 activation may be the cell cycle regulated event that determines the timing of emi1 destruction.
16033797 Data suggest that Cks30A interacts with Cdk1, and may regulate Cyclin A levels through the activity of a female germline-specific anaphase-promoting complex, CDC20-Cortex.
12105185 nonmuscle myosin II regulation by Cdc2 activity
15581871 Data show that down-regulation of Cdc2 delayed pI mitosis and altered the polarity and the number of subsequent cell divisions.
16120647 Our findings suggest a model where mitotic disassembly/reassembly of the NPCs is regulated by a dynamic equilibrium of Cdk1 and OA-sensitive phosphatase activities and provide evidence that mitotic phosphorylation mediates disassembly of the NPC.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDCyclin D CG9096-PA, isoform A [Drosophila melanogaster].cdc2 CG5363-PA [Drosophila melanogaster].cdc2 (Cdk1) interacts with CycD (Cdi3).-Pubmed
BINDcdc2 CG5363-PA [Drosophila melanogaster].-Cyclin B interacts with Cdk1.-Pubmed
BINDcdc2 CG5363-PA [Drosophila melanogaster].Cyclin E CG3938-PB, isoform B [Drosophila melanogaster].cdc2 (Cdk1) interacts with CycE (CycEI).-Pubmed

cdc2 results (if any) from reagent suppliers

Google CSE Logo
Cdc2 antibody (ab6537) | Abcam
Rabbit polyclonal to Cdc2 . The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the ...
http://www.abcam.com/cdc2-antibody-ab6537.html...

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Phospho-cdc2 (Tyr15) Antibody #9111
Western blot analysis of extracts from Saos cells, either untreated or treated with hydroxyurea or nocodazole, using Phospho-cdc2 (Tyr15) Antibody #9111 ...
http://www.cellsignal.com/products/9111.html...

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cdc2 Kinase, Chapter 7
A simplified scheme for activation of cdc2 protein kinase. ... The cdc2 kinase is inactivated by ubiquitin (Ub)-dependent degradation of cyclin B ...
http://www.promega.com/guides/sigtrans_guide/strg_chap07.pdf...

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Phospho-cdc2 (Thr161) Antibody #9114
Phospho-cdc2 (Thr161) Antibody detects endogenous levels of cdc2 only when phosphorylated at threonine 161. The antibody cross-reacts with endogenous CDK2
...
http://www.cellsignal.com/products/9114.html...

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Cdc2 p34 (PSTAIRE) Antibody sc-53
See how others have used Cdc2 p34 (PSTAIRE): sc-53 antibody and or Cdc2 p34 ... Western blot analysis of Cdc2 p34 expression in HeLa nuclear extract (A) and ...
http://www.scbt.com/datasheet-53-cdc2-p34-pstaire-antibody.h...

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CDC2 Antibody
Specific antibody for the gene product of CDC2, the protein Cell division cycle 2. Validated for specificity by gene-silencing with siRNA followed by ...
http://www.piercenet.com/products/browse.cfm?fldID=351A2446-...

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cdc2 Antibody
regulated by activation of cdc2 kinase. Activation of cdc2 ... regulatory step in activating cdc2 during progression into ...
http://www.cellsignal.com/pdf/9112.pdf...

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