Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17991453 |
Use of a strategy consisting of IGF-1 determination in blood is predictive of growth hormone deficiency. |
| 18163429 |
Evidence for association between IGF-i single-nucleotide polymorphisms has been found. |
| 18199734 |
Genetic variants in the IGF-I genes is not associated with breast cancer |
| 18236213 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18237549 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18308828 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18316725 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18317720 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18349294 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17484040 |
IGF1-19/-19 genotype was significantly more common among BRCA1 mutation carriers (14.2%) than among non-carriers (4.8%) |
| 17911177 |
variation in the IGF-I gene plays a role in prostate cancer susceptibility by influencing circulating levels of IGF-I (Meta-Analysis) |
| 17666408 |
MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II. |
| 18003755 |
Blood levels are not significantly associated with metabolic syndrome among those with the lowest levels of 25-hydroxyvitamin D in a British cohort. |
| 17486636 |
Nordihydroguaiaretic acid inhibits IGF1 signaing, growth, and survival in neuroblastoma cells. |
| 18006148 |
IGF-1 and EGF down-regulation and FGF2 up-regulation seem to comprise the main features of endometrial carcinogenesis. |
| 17174724 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17179726 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17218729 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17289909 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17300730 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17311016 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17350302 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17376820 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17377412 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17484040 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17546465 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17555512 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17561390 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 17566087 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17724372 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17761791 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17851271 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17888024 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17895313 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17911177 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 18006928 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18031946 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18059035 |
Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18064566 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18163429 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18188667 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 14693733 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14714750 |
Observational study of genetic testing. (HuGE Navigator) |
| 14749262 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15049048 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15082485 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15181035 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15231015 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15247132 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15256976 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15272914 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15302607 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15386404 |
Observational study and meta-analysis of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 15586244 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15668470 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15668488 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15678496 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15726267 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15734965 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15756256 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15894673 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15927083 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15941947 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15986122 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16030120 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16215864 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16306136 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16322331 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16332723 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16361587 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16404426 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16418515 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16418517 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16448675 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16489531 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16498050 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16635594 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16645019 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16648498 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16873705 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16939403 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17010055 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17051426 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17062892 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17063263 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17096324 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17108398 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17142521 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11161840 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11246885 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11319179 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11768601 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11904589 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11937187 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12050240 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12115549 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12164325 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 12389335 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 12511011 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12590635 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12610514 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12732844 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 12791939 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 12800944 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 12915683 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14557458 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17164371 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18045956 |
Silent-RNA-mediated downregulation of BRCA1 in primary human breast cancer gland tumor cells triggers upregulation of endogenous intracellular IGF-I in vitro. |
| 17827385 |
IGF-1 plays a role in potentiating platelet aggregation by complementing G(i)- but not G(q)-signaling pathways via PI3-K p110alpha. |
| 17827393 |
IGF-1 activates the IGF receptor/IRS/PI3K/PKB pathway, and that PI3Kalpha is essential for the potentiatory effect of IGF-1 on platelet responses |
| 18177247 |
These findings suggest that serum levels of IGFBP-3 and possibly IGF-I are associated with the rate of HIV disease progression in women. |
| 17560756 |
the two systems, TRs and IGF1/IGF1R could be functionally associated. |
| 17904522 |
Data show that adipose tissue-derived stem cells (ASCs) secrete significant amounts of VEGF (810.65+/-56.92 pg/microg DNA) and IGF-I (328.33+/-22.7 pg/microg DNA). |
| 18037753 |
An inverse significant relationship between IGF-I and both brain natriuretic peptide (BNP) and amino-terminal propeptide of procollagen type III (P-III-P) value in surgically treated acromegaly patients was observed. |
| 17921143 |
PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion |
| 17895313 |
polymorphisms identified in the upstream core polyadenylation signal at IGF1 exon 6 do not cause IGF1 deficiency |
| 17920708 |
IGF-1 plays a role in maintaining muscle GLUT3 expression and basal glucose uptake via the transcriptional factor Sp1. |
| 18031946 |
no major role of the assessed genetic variation within the IGF1 and the IGFBP3 genes in CRC risk. |
| 17975158 |
Blocking Hsp90 disrupts IGF-I and IL-6-induced proangiogenic signaling cascades by targeting IGF-IR and STAT3 in pancreatic cancer |
| 17622956 |
Data show that an antenatal course of glucocorticoids elicited a transient catabolic state encompassing all nutrient substrates, and a temporary drop in IGF-I concentrations. |
| 17410466 |
IGF-I synthesis is disturbed in chronic hepatitis C and reflects the severity of the liver fibrosis; may be a biological marker |
| 17761791 |
IGF-1/PPP3R1 gene polymorphisms influence muscle phenotypic responses to strength training in both black and white older men and women. |
| 17574386 |
Dichlorodiphenylchloroethylene alters the expression of the ovarian growth factors VEGF and IGF-1 in vitro. |
| 17702838 |
Exercise-associated mechanisms, such as increased energy flux, regulate IGF-I independently of energy deficit. |
| 17617058 |
AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases. |
| 17066319 |
the expression of IGF-I and IGFIR genes may undergo substantial change over the course of breast tumorigenesis, and the pattern of changes may be associated with breast cancer prognosis |
| 17879951 |
In a group of older US men, the suggestion of a positive association between IGF-1 and lower urinary tract symptoms was observed. |
| 17957164 |
IGF-I levels determine aortic intima-media thickness in neonates with intrauterine growth retardation and in healthy controls. |
| 17721831 |
Low levels of IGF-1 found in obesity may be related to obstructive sleep apnea syndrome. |
| 17724372 |
Serum levels are indicative of prostate carcinogenesis. |
| 17912004 |
Osteopenia is common in children with cerebral palsy and may be associated with lower IGF-1 and IGFBP-3 levels |
| 17916769 |
IGF-1 infusion decreased atherosclerotic plaque progression in ApoE-deficient mice on a Western diet. |
| 17666470 |
Maternal diabetes is associated with significant alterations in IGF-1 blood levels in male newborns. |
| 16133873 |
These studies show IGF-I phosphorylation of FKHR and FKHRL1 via a PI3-K-dependent pathway in neuroblastoma cells. |
| 17051426 |
Genetic variation in IGF1 is associated with breast cancer risk |
| 17689128 |
No significant differences in levels in fibromyalgia patients. |
| 17851271 |
18-repeat genotype is a susceptibility genotype for diabetic retinopathy and its clinical severity in a Southern Indian cohort. |
| 17569567 |
Plasma levels of IGF-I were significantly increased in volunteers with alopecia after oral administration of capsaicin and isoflavone . |
| 17387582 |
These data point to an interesting relationship between low IGF-1 levels and increased cardiovascular risk factors among chronic kidney disease patients as compared to age-matched healthy control subjects. |
| 17597108 |
large prospective study showed no overall association between the insulin-like growth factor axis and prostate cancer risk, however, IGF-1:IGFBP-3 molar ratio was related to risk for aggressive prostate cancer in obese men |
| 17666477 |
IGF-I levels were lower in patients with ectopic neurohypophysis than in those without structural abnormalities of the hypothalamic pituitary axis (n = 25), but patients without structural abnormalities also had significantly lower serum IGF-I levels |
| 17666480 |
high serum IGF-I levels are associated with goiter |
| 17560154 |
Severely deficient in a case of insulin-resistance syndrome (Rabson-Mendenhall type). |
| 17566087 |
Common genetic variation in IGF1, IGF binding protein 1 (IGFBP1), and IGFBP3 influences circulating levels of IGF-I, IGFBP-1, and IGFBP-3. |
| 17377412 |
first study showing the role of the promoter region of the IGF-I gene polymorphism and the level of plasma IGF-I and body composition parameters in Japanese infants; results suggest genetical influence on prenatal growth and serum IGF-I levels |
| 16998819 |
Stromal cell IGF-1 mRNA levels are significantly decreased after castration in non-malignant, but not malignant prostate tissue. |
| 17561390 |
The IGF-I CA(19) promoter polymorphism is not likely to predict the risk of breast cancer risk in Caucasian postmenopausal women. |
| 17597610 |
These results raise questions concerning the therapeutic value of IGF-1 and indicate that further studies are needed to examine the relationship between methods of IGF-1 administration and its potential therapeutic value. |
| 17785698 |
Recombinant human insulin-like growth factor I therapy could improve glucose disposal by signalling through the IGF-I receptor, whilst reducing the adverse effects of high insulin concentrations. |
| 17082888 |
GH1/IGF-1 axis polymorphisms may have a role in breast cancer development [review] |
| 17418605 |
IGF-related peptides are most likely synthesized locally and might be involved in the initiation and/or progression of neointimal thickening of primary arteriovenous fistulas. |
| 17063263 |
polymorphisms in the IGF-1R and IGFBP3 genes, but not IGF-1 or IGFALS, may be associated with altered survival among subgroups of breast cancer patients defined by menopausal status |
| 17709895 |
Growth hormone deficiency alone does not account for the high prevalence of reduced IGF-1 in adult beta-thalassemia. |
| 17668637 |
No significant differences in grade or ethnicity was found in IGF1 repeats and the inverse association with prostate cancer risk |
| 17581609 |
novel role for autocrine IGF-I signaling in the growth and survival of primary acute myeloid leukemia cells |
| 17624368 |
Connexin43 expression can be influenced by Ang II and IGF-1 through ERK and p38 pathways and may contribute to the pathogenesis of vein graft disease following coronary artery bypass grafting. |
| 17652764 |
hyperglycemic conditions enhance the response of retinal endothelial cells to IGF-I by increasing the association of IAP with SHPS-1 permitting the formation of the SHPS-1-Shc signaling complex, which is required for the proliferative response to IGF-I |
| 17520698 |
IGF-1 regulates ether-a-go-go channel activity in breast neoplasms, via an Akt pathway to promote cell proliferation. |
| 17560457 |
The results of this study suggest a positive correlation between the increased levels of IGF-1 and colon cancer and are thus consistent with the hypothesis that the level of IGF-1 plays an important role in the development of colon cancer. |
| 17458902 |
IGF-I interacts with estradiol to promote the proliferation of breast carcinoma cells via reactive oxygen species-dependent MAPK activation and c-Jun protein expression. |
| 17412783 |
IGF-I system is important in the assessment of adaptation to stress imposed by high levels of physical activity and energy/sleep restriction and is more closely associated with losses in body mass and fat-free mass than other nutritional biomarkers. |
| 17651480 |
Strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients. |
| 17396115 |
Autosomal dominant polycystic kidney disease cells had an increased sensitivity to IGF1 and to cyclic AMP, which required PI3-kinase and the mitogen-activated protein kinase, extracellular signal-regulated protein kinase (ERK) for enhanced growth |
| 17264182 |
Circulating levels of total IGF-I were not associated with risk of total coronary events or ischemic stroke among older adults. |
| 17470458 |
IGF-1 rescue of AR toxicity is diminished by alanine substitutions at the Akt consensus site |
| 17330866 |
Mice, transgenic with IGF1, express multiple anti-apoptotic protein in epidermis. |
| 17377396 |
data confirmed hypothesis that higher growth velocity in the first month of preterm neonates is due to an increased bioavailability of IGF-I |
| 12011225 |
Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China. |
| 13130502 |
Recombinant human IGF-I increases gap junction communication and connexin43 abundance in primary astrocyte cultures from 2-day-old rats. |
| 11924928 |
plays an important role in the genetic and perhaps nutritional determination of adult stature in humans |
| 15641262 |
IGF-1 levels decreased significantly six months after the iodine supplementation. |
| 15641264 |
Serum IGF-1 levels differed significantly between pubertal developmental stages. |
| 12930919 |
IGF-I promoted maturation of cord blood monocyte-derived dendritic cells (DC) |
| 15302607 |
common wild-type allele of the IGF-I promoter polymorphism is associated with increased levels of fasting serum triglyceride in glucose-tolerant whites |
| 15522943 |
In obese compared with normal-weight healthy subjects, there is a larger increment IGF-I to a single bolus of growth hormone in men amd women. |
| 11972897 |
Extravillous cytotrophoblast differentiation requires at least two distinct steps: a column forms as a result of attachment to extracellular matrix, then IGF-I from placental mesenchymal cells stimulates progression to a fully migratory phenotype. |
| 12870155 |
endurance training may attenuate the aged-related decline in insulin sensitivity and insulin-like growth factor-I |
| 15187095 |
IGF-I-induced cell cycle progression is regulated by 14-3-3sigma |
| 15276114 |
Insulin like growth factor I polymorphism is associated with increased risk for heart failure in elderly patients. |
| 16306136 |
IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. |
| 16306230 |
Regions upstream and downstream of the CWCV motif in IGFBP2 participate in IGF-1 binding. |
| 16940243 |
IGF-1 cell signaling leading to collagen synthesis in fetal lung fibroblasts is mediated by PI3 Kinase acting through NF-(k)B in HFLF. |
| 17156777 |
Those results reinforce the possibility that the IGF-1Ec isoform may produce an E domain peptide that can act as a cytokine. |
| 17388800 |
IGFBP-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms |
| 14961074 |
Inhibition of E-cadherin function inhibits both IGF-I-dependent cancer cell migration and invasiveness. |
| 17545516 |
seminal vesicle fluid is a local source of IGF-I that provides chronic stimulation of prostate cells |
| 12562960 |
High resistance exercise resulted in a significant increase in mechano growth factor isoform of IGFI mRNA in young, but not in elderly subjects |
| 12909598 |
during a short-term energy deficit in young men, IGF-I system components differentially respond to a given metabolic perturbation and the relative proportion of IGF-I sequestered in ternary vs. nonternary molecular complexes appears to be well maintained |
| 14602779 |
IGF-I stimulates VEGF synthesis in thyroid carcinomas in an Akt-dependent pathway via AP-1 and HIF-1 alpha |
| 15221971 |
Association between high IGF-I and IGFBP-3 levels and increased risk of breast cancer in premenopausal women. |
| 15695599 |
Results indicate that the degree of prematurity, low enteral protein intake, male gender, and slow weight gain are associated with a slower postnatal increase of IGF-I in preterm infants. |
| 12201212 |
Maternal nitrogen balance in the regulation of circulating levels of insulin-like growth factor-I in human pregnancy. |
| 15820831 |
IGF)-1 and its receptor are present in the human male genital tract |
| 16778368 |
IGF-I and its downstream pathway is a valuable therapeutic approach to overcome Ara-C resistance in AML. |
| 11877670 |
Insulin-like growth factor-I protects neuroblastoma against starvation-induced apoptosis and is associated with increased Bcl-2 expression. |
| 15485651 |
IGF-1 induces AMPK-alpha subunit phosphorylation via an ATM-dependent and LKB1-independent pathway |
| 15505506 |
contributes toward forming and mineralizing dental tissues as well as in pulp-repairing processes |
| 16926156 |
heterotrimeric G protein-dependent ERK1/2 activation is mediated by IGF-1 and IGF-2 by transactivating sphingosine 1-phosphate receptors |
| 17107821 |
upregulation of the muscle specific IGF-IEa and MGF isoforms occurs within 2.5h of a single bout of isometric exercise in women |
| 17090643 |
the differences in the IGF-I response to GH between tall obese and short children may reflect differences in the respective anabolic (growth promotion) and metabolic (i.e. insulin action modulation); roles of circulating IGF-I is unknown |
| 17174724 |
Individuals with IGF-I189 are more likely to have low leg lean mass and to perform better in activities requiring exercise economy and endurance performance. |
| 17187018 |
exposure to hypoxia and acidosis at birth strongly correlated with a fall in IGF-1 and IGFBP-3 levels in cord blood |
| 12858577 |
Insulin-like growth factor-1 isoforms in skeletal muscle aging, regeneration, and disease. Review. |
| 15477425 |
Review. IGF-1 protects against endothelial dysfunction, atherosclerotic plaque development, the metabolic syndrome, clinical instability, and ischemic myocardial damage. |
| 15618451 |
increased expression of human IGF-IA in alveolar air spaces does not affect the development of pulmonary fibrosis but promotes premalignant changes in the alveolar epithelium. |
| 11897674 |
IGF-I may promote granulocyte functions by increasing granulocyte longevity |
| 12592062 |
results suggest that trunk fat attenuates the hormone replacement therapy-induced increase on growth hormone levels and is a significant determinant of low IGF-1 levels in postmenopausal women |
| 16516166 |
These results show that AICAR and insulin/IGF-1 regulate VEGF expression through different mechanisms. |
| 15047131 |
Following severe burn, a shift occurs toward a predominant Th2 phenotype. Exogenous IGF-I/IGFBP-3 treatment partially reverses this response. |
| 16820871 |
VEGF, FGF2, TGFB1, EGF and IGF1 have roles in the development of both prostate cancer and benign prostatic hyperplasia |
| 12356750 |
H358 cells secrete a high level of amphiregulin that, in combination with IGF1, prevents serum deprivation apoptosis |
| 15272501 |
evidence suggests that decreased IGF-1 levels and signaling during early development may modulate longevity in many species--REVIEW |
| 15086466 |
Renal cell carcinoma (RCC) expresses IGF-I and IGFBP-3 and is responsive to exogenous IGF-I stimulation. In metastatic RCC, autocrine IGF-I and IGFBP-3 stimulated and inhibited growth. IGF-I and IGFBP-3 possible treatment in advanced RCC. |
| 15247132 |
The IGF1 was not associated independently with colon cancer, but there was an association when examined with IRS1. Individuals with an IRS1 R allele and IGF1 non-192 allele were at a 2-fold increased risk of colon cancer (95% CI 1.2-4.4). |
| 12729801 |
results indicate that IGF-I-stimulated migration of WM1341D melanoma cells requires phosphoinositide 3-kinase activation but is independent of mitogen-activated protein kinase/extracellular signal-regulated kinase signaling |
| 12746292 |
When IGF-I was added, the reduction in prostate cancer LNCaP cell growth and the induction of apoptosis in medium containing serum alone were reversed. |
| 17363178 |
Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF1 hypothesis of osteochondrodysplasias. |
| 15254679 |
DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling |
| 15489542 |
Tumor necrosis factor-alpha was more effective at inhibiting differentiation in subcutaneous cells, whereas insulin-like growth factor-I stimulated differentiation more effectively in visceral cells |
| 16189249 |
Clustering of family history of diabetes, testosterone and IGF I abnormalities, and high high-sensitive C-reactive protein is associated with metabolic syndrome in Chinese middle-aged men. |
| 15986122 |
Increased breast cancer risk in women with promoter polymorphisms in IGF1 and IGFBP3 genes, with increased risk for individuals homozygous for both polymorphisms. |
| 16244494 |
observations demonstrate that leptin directly controls the secretory activity of human ovarian cells and confirm the involvement of insulin-like growth factor (IGF)-I in the regulation of ovarian cells |
| 12032677 |
results suggest that IGF-1/PI-3 kinase inhibited C2-ceramide-induced apoptosis due to relieving oxidative damage, which resulted from the inhibition of catalase by activated caspase-3 |
| 16728464 |
progenitor cells are potent sources of VEGF, HGF, and IGF-I |
| 16831875 |
Data show that hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. |
| 17447118 |
Serum testosterone concentration and serum IGF-1/IGFBP-3 molar ratio are the major determinants of bone mineral density in boys at different pubertal stages. |
| 11953210 |
Relation between insulin-like growth factor-1 and insulin resistance in patients with acute stroke |
| 12217887 |
IGF-I does not affect the net increase in GH release in response to arginine. |
| 12006706 |
determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation |
| 12005306 |
cDNA probes were used to analyze the gene expression of IGF-I in luteinized granulosa cells from different-sized follicles after ovarian hyperstimulation. |
| 15556609 |
The effect of serum withdrawal on the autophagy of dysfunctional mitochondria is prevented by the addition of IGF-1. |
| 15767261 |
AR and IGF1 cooperate to prevent apoptosis by activating a specific PKC-p90(rsk)-dependent pathway, which leads to Bad and Bax inactivation. |
| 15867218 |
Increased IGF-I levels correlated with increased growth, tumor extent, and aggressiveness. |
| 16051222 |
IGF-I is degraded at its C-terminal D-domain within the endosomal apparatus by cathepsin B. |
| 17015410 |
Platelet factors promote fibroblast growth by activating preotein kinaes, which requires production of IGF-1. |
| 17044098 |
lack of association of schizophrenia with 16 SNPs spanning the IGF1 gene with an inter-marker distance of approximately 2-3 kb |
| 17363459 |
Presence of two Androgen Receptor response elements within the IGF-I upstream promoter that act in cis to activate IGF-I. expression. |
| 12716804 |
Poor glycemic control and differences in IGF-I levels and androgens accompany development of microalbuminuria at puberty; differences may account for sexual dimorphism in microalbuminuria risk during puberty and to disease progression |
| 12716855 |
Levels are altered in diabetic angiopathies. |
| 12716875 |
IGF-I isoform a expression may be downregulated at the mRNA level during the initial part of recovery from resistance exercise |
| 16670160 |
results support the contention that the associations between height and cancer may be mediated by variation in childhood insulin-like growth factor 1 |
| 11914023 |
Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease. |
| 12011046 |
IGF-I protects the cells from apoptosis by blocking the activation of caspases, which may be responsible for the loss of FAK and Akt. |
| 12062094 |
insulin growth factor 1 via activation of the serine/threonine kinase Akt/PKB is able to inhibit neuronal death specifically induced by mutant huntingtin containing an expanded polyglutamine stretch |
| 12642873 |
activates p21 to inhibit UV-induced cell death |
| 14674122 |
progesterone increased local IGF-I bioavailability in malignant breast tissue; this depended on steroid receptor phenotype of breast tissue and was most evident in tissue expressing progesterone receptor |
| 14757186 |
Insulin-like growth factor-I (IGF-I) is sensitive to nutrient supply in hatching chicks, and fasting reduced IGF-I mRNA levels in muscles of older chickens. |
| 14749262 |
Both first- and second-phase insulin secretion were not significantly different between the various IGF-I or IGF-II genotypes. |
| 15217931 |
free IGF-II but not IGF-I may have a role in progression of breast cancer |
| 15140223 |
IGF-II:VN and IGF-I:IGFBP-5:VN complexes may be useful in situations where enhanced keratinocyte cell migration and proliferation is required, such as in wound healing and skin regeneration. |
| 15231015 |
The CA-repeat promoter polymorphism in the IGF-I gene is associated with the risk for fragility fracture at old age in women and with bone structure in both genders. |
| 15292338 |
In a model of severe undernutrition, rhIGF-I and estrogen individually increase ghrelin levels. |
| 15688209 |
Megative and independent association between ghrelin and IGF-I concentrations in middle-aged subjects, which is modified by obesity. |
| 15537892 |
Recombinant human IGF-I regulates progenitor cell division in the ventricular zone by reducing G1 phase length and decreasing total cell cycle length but increases cell cycle reentry in mouse embryos. |
| 15653207 |
higher serum levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) in polycystic ovary syndrome (PCOS) women may be related to the increased vascularity that underlies the increased ovarian blood flow |
| 15616244 |
IGF-I has the characteristics to be a marker for the insulin resistance syndrome. |
| 15932773 |
leptin and the IGF system of IGF-I, IGFBP-2, and IGF-I receptor do not interact directly in a cell culture model of neuroepithelioma cells |
| 14715837 |
low baseline levels of insulin-like growth factor-I and insulin-like growth factor binding protein-1 increase the risk of fatal ischemic heart disease among elderly men and women independent of prevalent risk factors |
| 14973173 |
Data show that differentiated thyroid cancers of children and adolescents express IGF-I and IGF-I receptors. |
| 16044163 |
insulin-like growth factor-I increased invasion activity in ARK5-mRNA expressing multiple myeloma cell lines |
| 16161053 |
Age-stratification should be undertaken in larger investigations of IGF-I levels as predictors of postmenopausal breast cancer |
| 12122101 |
Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer. |
| 15451424 |
Thus, in RPE cells IGF-1 stimulates the second messenger Ca(2+) and increases VEGF secretion which, in turn, induces neovascularization. |
| 16019437 |
following UV insult the IGF system, including IGF-1 may enhance keratinocyte viability and contribute to a return to epidermal homeostasis |
| 12571183 |
Follicular fluid IGF-1 and IGFBP-3 levels were not significantly different among the groups; however, follicular fluid IGFBP-1 levels were lower in those patients with moderate/severe endometriosis |
| 15135045 |
the functional epitope of IGF-I for IGF-II comprises residues in the N-terminal L1 domain and residues at the C-terminus of the alpha subunit |
| 12381752 |
Intense physical training results in a marked influence on the IGF system and its binding proteins with generally more extensive changes seen in the untrained individuals. |
| 15098919 |
an important role of IGF-I in the pathogenesis and invasiveness of the malignant thyroid neoplasms |
| 11867942 |
Functional insulin-like growth factor-1/insulin-like growth factor-1 receptor-mediated circuit in human and murine thymic epithelial cells. |
| 12915683 |
insulin-like growth factor 1 promoter polymorphism or another functional polymorphism in linkage disequilibrium may be a genetic determinant of bone mineral density levels and rate of bone loss in postmenopausal women. |
| 14504195 |
We conclude that IGF-I plays a dominant role in growth during the perinatal period and that all three studied components of the IGF system are sensitive to liver and kidney function. |
| 15509657 |
Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in tumor cells |
| 15894537 |
Thus these data suggest that the IGF1 promoter polymorphism may influence the strength response to ST. Larger sample sizes should be used in future studies to verify these results. |
| 14697248 |
IGF-I-induced PI3K signaling is responsible for IGF-IR mediated attenuation of antineoplastic agent-induced growth inhibition |
| 15210945 |
EPO+IGF-I exert cooperative actions that afford acute neuroprotection via activation of the PI3-K-Akt pathway |
| 11943599 |
In demonstrating transduction of fascin spike assembly by activation of a peptide growth factor receptor, these novel data reveal a wide role for fascin spikes in cell motility |
| 14668202 |
A physiologic intrafollicular dose of IGF-I did not stimulate estradiol production but reduced the production of androstenedione and stimulated the production of activin-A, inhibin-A, and VEGF during follicle selection in mares. |
| 15223841 |
somatotropin-IGF-I axis contributes to changes in bone density and male reproductive organs. |
| 15657590 |
The induction of the raf-1/MEK1 pathway blocks IGF-1-mediated intracellular neuroendocrine hormone regulation. This pathway may be a therapeutic target in gastrointestinal carcinoid tumor therapy. |
| 16635594 |
We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction |
| 16825188 |
Upon IGF-I stimulation, a complex assembles on SHPS-1 that contains SHP-2, c-Src, and Shc wherein Src phosphorylates Shc, a signaling step that is necessary for an optimal mitogenic response |
| 16846747 |
IGF-I can augment IL-8 expression through activation of AP-1. |
| 16868142 |
reduction in bioactive IGF-I may be related to the higher levels of free IGFBP-1 and the faster disappearance of IGFBP-1-bound IGF-I in glucose tolerance test in liver cirrhosis |
| 16873705 |
findings suggest that this insulin-like growth factor 1(IGF-I) gene polymorphism is associated with an increased risk of diabetic retinopathy |
| 16924115 |
The structures reveal the mechanisms of insulin-like growth factor (IGF) signaling regulation via insulin-like growth factor-binding proteins (IGFBP) binding. |
| 16969385 |
This study demonstrates a direct interaction of the IGF and TGF-beta systems in human renal carcinoma cells. The observations that IGF-I enhances the TGF-beta signaling and that TGF-beta promotes IGFBP-3 production. |
| 16981855 |
Precise orientation of IGF-I within the IGF-I-IGF-1R complex involving the IGF-I C-domain binding to the IGF-1R CR domain. |
| 17010055 |
High insulin-like growth factor-1 levels are associated with early-onset breast cancer |
| 17265493 |
Chondrocytes with low chondrogenic capacity expressed higher levels of IGF-1, MMP-2, aggrecanase 2, while chondrocytes with high chondrogenic capacity expressed higher levels of CD44, CD151, and CD49c. |
| 17255202 |
alterations in glucose concentrations may regulate the ability of smooth muscle cells to respond to IGF-I |
| 12509920 |
Decrease of serum IGF-I level may play a role in the cognitive impairment in patients with obstructive sleep apnea syndrome (OSAS). |
| 12175483 |
Insulin-like growth factor-1 and myostatin mRNA expression in muscle: comparison between 62-77 and 21-31 yr old men |
| 12388463 |
Glucose transporter gene expression in the jejunum in response to insulin-like growth factors in rat pups |
| 12519841 |
data demonstrate for the first time that serum levels of IGFs (including free fractions) and IGFBPs are not increased in euthyroid Graves' patients with active thyroid eye disease |
| 12791939 |
Hypertensive subjects who have low IGF-I levels because of a genetic polymorphism in the IGF-I gene are at increased risk of developing atherosclerosis |
| 14604834 |
Review. IGF-1 exerts multiple physiologic effects on the vasculature, including proliferative, hypertrophic, survival, vasomotor, & metabolic effects. IGF-1 & its receptor & binding proteins & involvement of this system in vascular diseases are reviewed. |
| 15033949 |
Progesterone down-regulates IGF-I mRNA and protein expression in cultured leiomyoma cells without affecting IGF-I receptor mRNA expression. |
| 12508915 |
Correlation between IGF-I and Mini Mental State Examination in Alzheimer's disease suggests a mechanism involving immuno-somatopause in progression of dementia. |
| 12508916 |
Above threshold of GH hypersecretion, IGF I levels reach plateau and are no more associated with GH secretion. |
| 12508917 |
Reduced IGF I secretion in normal elderly subjects not due to alteration of nutritional status. |
| 12508918 |
IGF I levels within 24 hours from stroke onset significantly and inversely related to poor outcome and death. Lower in acute ischemic stroke than in controls. |
| 12508929 |
Significant reduction of serum IGF I in centenarians in comparison to normal adults and normal elderly. |
| 12508940 |
Data suggest role for IGF I in control of blood pressure in obesity. |
| 15221500 |
lower serum IGF-I levels are risk factors for lower bone mineral density in middle-aged Korean men |
| 12218293 |
The biological relevance of this finding is suggested by the significant association between local IGF-I mRNA levels and microvessel density in the colorectal cancers. |
| 14691340 |
IGF-1, IGFBP-2 levels were related to IL levels, disease activity and anatomical distribution, consistent with active inflammation modifying the IGF-IGFBP system, possibly relevant to disturbance of growth. |
| 12631341 |
IGF-I induces VEGF gene expression and protein secretion in human mesangial cells via a Src-dependent mechanism. |
| 15256490 |
Ceramide, derived both from sphingomyelin and de novo synthesis, is a key intermediate by which proinflammatory cytokines impair the ability of IGF-I to promote protein synthesis and expression of critical muscle-specific transcription factors. |
| 15517912 |
Elevated serum IGF-1 levels may be an important predictor of risk for esophageal cancer. IGF-1 related to the progression of esophageal cancer may depend on an autocrine function of IGF-1. |
| 15528386 |
IGF-1 may play a role in the selective recruitment of basophils in vivo. |
| 15780948 |
Studies in transgenic (OC-IGF-I) mice show that osteoblast-derived IGF-I determines skeletal insulin-like growth factor binding protein 5 (IGFBP-5) abundance, at least in part by inducing its synthesis. |
| 16195423 |
The results show that occupancy of the alpha(v)beta(3)-integrin receptor modulates IGF-I-induced IGF-I receptor activation and function in human intestinal muscle cells. |
| 16294334 |
IGF-I actions likely depend on cell type, developmental stage, and microenvironmental milieu {REVIEW} |
| 16716629 |
Effect of human IGF-I over-expression on mice skeletal muscles was studied. |
| 17033263 |
This review of available data suggests an algorithm of circulating levels of IGF-I, together with evaluation of auxological data, to assess the likelihood of growth hormone deficiency in pre-pubertal children. |
| 17033713 |
Seems to be an important positive regulator of cartilage oligomeric matrix protein. |
| 17234973 |
IGF-1 stimulated EPC differentiation, migration & incorporation into vascular networks in vitro via its receptor, increased telomerase activity & endothelial nitric oxide synthase expression, phosphorylation & activity in a PI-3-kinase/Akt-dependent way. |
| 17254778 |
1,25-dihydroxyvitamin D and/or IGF-I may be involved in the regulation of urinary calcium excretion |
| 17425608 |
IGF-I-immunoreactivity was confined to secretory granules in coexistence with ACTH- or GH-immunoreactivity, respectively, indicating a concomitant release of the hormones. |
| 11822578 |
IGF-I level was significantly lower in the CDGP (constitutional delay of growth and puberty)group |
| 11914026 |
Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly. |
| 12545204 |
REVIEW: from diagnostic to triple-helix gene therapy of solid tumors. |
| 12727948 |
combination of low insulin-like growth factor-I and high interleukin-6 levels confers a high risk for progressive disability and death in older women |
| 12759337 |
The terminal complement complex inhibits apoptosis in vascular smooth muscle cells by activating an autocrine IGF-1 loop. |
| 12937269 |
IGF-I enhances adhesion via inactivating focal adhesion kinase |
| 12937290 |
IGF-1 prevents age-related decline in peak intracellular Ca2+ and specific force in a muscle that does not exhibit changes in fibre type composition with senescence. |
| 14673951 |
The IGF-1 axis is upregulated in prostate carcinoma cells that have resided in bone. |
| 15548698 |
AIB1 is required for IGF-I-induced proliferation, signaling, cell survival, and gene expression in human breast cancer cells, independent of its role in estrogen receptor signaling |
| 15849510 |
IGF-I and HGF cooperate to induce migration and invasion of colorectal carcinoma cells, and c-Met and uPA/uPAR are required for IGF-I-mediated migration and invasion. |
| 12050240 |
Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age |
| 12397390 |
IGF-1 induces a transient increase followed by a decrease of CCE, and that these effects are at least partly dependent on IGF-1-induced K(+) channel activity. |
| 11858767 |
lower IFG-I concentrations correlate with higher bone resorption markers values and decreased mineralisation |
| 15514031 |
IGF-I modulates androgen signaling through beta-catenin |
| 11909998 |
is essential for normal growth and mutations are associated with extreme growth retardation in mice and humans and the relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question |
| 12135130 |
circulating levels of IGF-1 and IGFBP-1 are significantly related to the extent of myocardial injury in patients with hypertrophic cardiomyopathy. |
| 12135360 |
structural origins of the functional divergence with insulin |
| 12364325 |
Insulin-like growth factor I causes nuclear accumulation of cyclin D1 in tumor cell lines |
| 12960100 |
IGF-I signals osteoblast mitogenesis and survival through parallel, partly overlapping intracellular pathways involving PI-3 kinase, p42/44 MAPKs, and G beta gamma subunits. |
| 15240644 |
IGF-I may play a critical role in adipocyte differentiation and lipid accumulation. |
| 15661050 |
The expression of IGF-I is significantly altered in renal cell carcinoma |
| 16159864 |
IGF-I may act to limit atrophy and apoptosis during reverse remodeling and to promote repair and regeneration in concert with stromal cell derived factor. |
| 12070137 |
IGF1 mediated AKT activation delays radiation-induced apoptosis, allowing the DNA repair mechanism more time to remove cyclobutane thymine dimers. |
| 12236578 |
IGF1 has a role in producing extracellular matrix components in human umbilical cord serum and tissues |
| 12394769 |
Serum levels of insulin-like growth factor-1 and insulin-like growth factor-1 binding proteins after radical prostatectomy |
| 15579776 |
Endogenous gonadal steroid secretion appears to result in increased responsiveness to GH in peripubertal girls and boys. |
| 12734180 |
IGF-1 and OP-1 could be key physiological regulators of MMP-13 gene expression |
| 15845624 |
IGF-I uses different and only partially overlapping intracellular signaling pathways for regulation of IGFBP-3 and -5 with opposing biological functions might be important for modulation of IGF bioactivity in cellular microenvironment. |
| 12555073 |
regulation of signaling in breast cancer by JN kinase |
| 12842994 |
IGF-1 plays a critical role in the desensitization of IFN-gamma/STAT-1 signaling in T lymphocytes by delivering a signal for IFN-gamma R2 internalization |
| 12843178 |
possible stimulatory effect of endogenous GH on IGF and IGF-binding protein (IGFBP) levels during fasting. |
| 12843179 |
free IGF-I plasma levels and human longevity are coregulated by an overlapping set of genes so the impact of the IGF-I/insulin pathway on longevity is a property that has been evolutionarily conserved throughout the animal kingdom. |
| 12843187 |
IGF-I clearly stimulates telomerase activity in prostate cancer cells through a dual mode of action, including early rapid effects probably involving phosphorylation of hTERT by Akt and later up-regulation of hTERT expression. |
| 12679458 |
maternal insulin-like growth factor-I levels, especially during late pregnancy, positively influence birth weight |
| 15692088 |
Recombinant human IGF-I promotes proliferation and inhibits osteoblastic differentiation and mineralization of bovine vascular cells via both ERK and PI3K pathways. |
| 15735081 |
Hepatic immunoreactive IGF-I was significantly correlated with serum IGF-I and nitrogen balance. |
| 15756256 |
High IGF-1 levels are linked to early-onset breast cancer and larger breast volumes. |
| 15891958 |
Pituitary gamma-knife surgery in acromegaly is effective in lowering serum IGF-I to normal levels. |
| 15879687 |
higher levels of circulating IGF-I may increase risk of several cancers and relatively higher IGF-I levels may reduce the risk of type 2 diabetes and coronary heart disease. |
| 16412381 |
The IGF-I-mediated phosphorylation and inhibition of PARP represent a novel mechanism of VEGF protein expression. |
| 16720666 |
first study to document an association between timing of puberty and adult insulin-like growth factor 1(IGF-I) levels |
| 16724947 |
The mechanisms by which IGF-I may influence bone metabolism are not fully understood, but as the reviewer points out, they are a predictor of bone mass density and are positively associated with vitamin D concentrations. |
| 16785149 |
higher concentrations of neuropeptide Y in constitutional delay of puberty(CDP) girls may be responsible for CDP and reduced levels of insulin growth factor-I(IGF-I) |
| 16840657 |
The results suggest that IL-6 plays a role in the GH-->IGF-I response to intense exercise. |
| 16887362 |
A decrease in free IGF-I and insulin-like growth factor binding protein 3 levels, along with increases in blood pressure, significantly influenced the presence of diabetic complications |
| 17006543 |
insulin-like growth factor-1 alters Mdm2-mediated GRK2 degradation, leading to enhanced GRK2 stability and increased kinase levels |
| 17010800 |
results may indicate that up-regulation of the cardiac IGF-1 system serves as a compensatory mechanism for LV dysfunction |
| 17045571 |
These results demonstrate that estradiol positively regulates essential proteins of the IGF signalling pathway. |
| 17116217 |
Cerebrospinal fluid levels are lower in motor neuron disease than in normal controls. |
| 17133354 |
Among patients with early-stage node-negative breast cancer, disease-free survival (DFS) and overall survival (OS) curves were significantly different based on IGF-1 and KCC expression. |
| 17148586 |
inhibition of IGF-1 signaling combined with interferon-gamma administration could be a promising approach to suppress the growth of neoplastic T cells resistant to each treatment on its own |
| 17166846 |
IGF-1 increases nuclear translocation of liganded estrogen receptor (ER)-alpha in breast cancer cells. |
| 17179152 |
study elucidates a mechanism by which insulin and IGF-1 signaling can be matched to the oxygen level that is available to support growth and energy metabolism. |
| 17289286 |
Review provides novel and fundamental knowledge regarding the regulatory actions of IGF-1 in promoting vasodilation and its clinical applicability in preventing dysfunction and sodium pump activity in type 1 diabetes. |
| 17317669 |
IGF-1 induces phosphorylation and an increase of the AP1 complex, which is phosphorylated and binds to the pS2/TFF1 promoter, allowing recruitment of the chromatin remodeling factor Brg1 followed by binding of ERalpha via its interaction with c-Jun |
| 17385724 |
IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system |
| 17499312 |
the IGF-1 axis is downregulated by curcumin in MCF-7 cells, which inhibits cell growth and induces apoptosis |
| 11825899 |
Protein kinase C-dependent, CCAAT/enhancer-binding protein beta--mediates expression of IGF-I |
| 12590635 |
A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels. In homozygous carriers of the 192 bp alleles of the IGF-I gene an age-related decline in circulating total IGF-I levels. |
| 12590636 |
Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts. |
| 12867429 |
p21CIP/WAF is a positive regulator in the cell proliferation induced by IGF-I in MCF-7 cells |
| 14557458 |
Haplotype analysis in the Swedish short small for gestational age subjects showed that the region of association lay between the promoter and intron 2 of the IGF-I gene. |
| 14605256 |
IGF-I may be a mediator of steroid effect during precocious maturation of the ileal mucosa. |
| 14710345 |
Sserum IGF-II shows positive correlations with myoblast retrieval in control patients that is lost in malignancy. |
| 14710346 |
IGF-I increases expression of VEGF-A in sarcoma and umbilical vein endothelial cells. |
| 14710359 |
IGF-I treatment stimulated cell growth and proliferation, but also mildly induces apoptosis in an osteosarcoma cell line. |
| 14647921 |
insulin-like growth factor I signaling has a role in neurodegenerative diseases (review) |
| 14761840 |
no significant differences between normal and reduced bone mineral density for serum IGF-1 |
| 11877395 |
role for IGF-I in the regulation of the MDM2/p53/p21 signaling pathway during DNA damage |
| 12086966 |
A putative functional polymorphism associated with NIDDM, adult height, glucose tolerance and fetal growth |
| 12127559 |
Autocrine production of IGF-I and IGF-II may via IGF-IR play a significant role in the growth and megakaryocytic differentiation of K562 cells. |
| 14633859 |
Cooperation between CTGF and IGF-I might be involved in glucose-induced matrix accumulation in tubulointerstitial fibrosis and might contribute to pathogenesis of diabetic nephropathy. |
| 15090033 |
Transgenic IGF-I promotes proliferation of neural cells in the embryonic central nervous system of transgenic mice in vivo and inhibits neural cell apoptosis during postnatal life of the animals. |
| 15576456 |
Val44 is an essential residue involved in the IGF-IGF-1R interaction, and a a naturally occurring mutant human IGF-I is associated with growth and developmental abnormalities |
| 11762714 |
Hypothyroidism is associated with significant reductions of IGF-1 |
| 12186542 |
The different energetic state of the intra A-chain/domain disulfide of insulin and insulin-like growth factor 1 is mainly controlled by their B-chain/domain. |
| 14690534 |
IGF-1 enhances uncoupling protein 3 expression at transcriptional level, primarily through the phosphatidylinositol 3-kinase-dependent pathway and partly through the MAP kinase pathway. |
| 14691011 |
Human fat cells protect themselves from apoptosis by IGF-I in an auto-/paracrine manner. |
| 15809062 |
PTEN may inhibit antiapoptotic IGF actions not only by blocking the IGF-IGFR-induced Akt activity, but also by regulating expression of components of the IGF system, in particular, upregulation of IGFBP-3 |
| 15888547 |
SHPS-1 functions as an anchor protein that recruits both Shc and SHP-2, whose recruitment is necessary for IGF-I-dependent Shc phosphorylation |
| 16330010 |
Lower serum IGF-I concentration together with higher bone resorption and low bone mineral density reveal involvement of this growth factor in the development of idiopathic decrease of bone mass in children. |
| 16394092 |
IGF-I and IGFBP-3 levels were positively associated with weight gain and height gain from birth to 3 months in small for gestational weight versus appropriate weight children. |
| 16433617 |
Igf-I transduction up-regulated markers of osteoblastic differentiation and in conjunction with recombinant BMP-2-induced matrix mineralization independently of Dex. |
| 16716263 |
IGF-I and -II are chemotactic factors for mesenchymal progenitor cells; IGFBP-5 both modulates the IGF-I effect and directly stimulates migration of human mesenchymal progenitor cells |
| 16807888 |
overexpression of rtEa4 or hEb transgene in zebrafish embryos disrupts heart development, hematopoiesis, and vasculogenesis by reducing the levels of GATA 5, NKX2.5, GATA 1, GATA 2, and VEGF mRNA |
| 16847815 |
concurrent administration of tamoxifen and bicalutamide in prostate cancer patients reduces the synthesis and bioavailability of IGF-1 |
| 16955207 |
Low levels of IGF-I may be a useful predictor of abnormal glucose metabolism in patients with acute myocardial infarction. |
| 16970944 |
transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2) |
| 17096324 |
Results indicate that common variation in the IGF1 gene, particularly in the 3' region, may affect prostate cancer risk. |
| 17164408 |
Results suggest a major role of IGF1 system in promoting cholangiocyte survival. |
| 17211256 |
the increase in LVM prevalent in human essential hypertension is directly associated with serum GH levels and inversely related to circulating IGF-1 |
| 14631161 |
study showed decreased levels of serum insulin-like growth factor 1 (IGF-1) and increased levels of growth hormone (GH) in the hypoxic-ischemic (HI) brain of newborns |
| 11834727 |
Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture. |
| 11964397 |
RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. |
| 12240900 |
GH-IGF-I axis in non-obese women with functional hyperandrogenism. |
| 12714114 |
This study suggests that IGF-I levels below 9.4 nmol/l are negatively associated with both the level and decline of information processing speed, in a prospective study of 3-year cognitive decline in 1318 subjects aged 65-88. |
| 12919702 |
The effects of IGF-I are differentiation dependent and restricted largely to the more mature cells of the osteoblast lineage. |
| 15304489 |
IGF-1 can regulate RUNX2 DNA binding through sequential activation of the PI3K/Pak1 and ERK1/2 signaling cascade |
| 15616898 |
Serum IGF-1 levels and IGF-1/Insulin-Like Growth Factor Binding Protein 3 ratios increased with advancing pubertal stages |
| 16000303 |
Osterix regulation by IGF-I requires all three MAPK components (Erk, p38, and JNK) in human mesenchymal stem cells |
| 15848608 |
response rate of hematocrit to enalapril treatment in patients with post kidney transplant erythrocytosis affects IGF1 levels. |
| 11735247 |
transcription is regulated by the PAX3-FKHR oncoprotein |
| 15067513 |
Recombinant human IGF-I increased renal p21 and PCNA expression, but reduced cyclin D1 expression in CDDP-treated kidneys. May ameliorate renal damage, in part by stopping the cell cycle at G1/S phase. Promotes recovery from ischemic renal injury. |
| 16111879 |
Folic acid deficiency could result in reduction of IGF-1 protein levels and might contribute to formation of defects in the skull bone as observed in mengingocele patients |
| 16352683 |
Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults. |
| 16352686 |
Leptin and the molar excess of leptin receptor are better biomarkers of nutritional status than IGF-I in protein malnutrition children during nutritional recovery. |
| 16369467 |
results show a local increase in the expressions of IGF-1 and PDEGF in the muscularis propria of the pyloric muscle in children with IHPS, which may have implications to the pathogenesis of the disease. |
| 12419777 |
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. IGF-I was an independent predictor of muscle function only in lowest IL-6 tertile. |
| 15950665 |
The action of insulin-like growth factor-1 might be responsible for elevated luteinizing hormone levels and the consequent hyperandrogenic anovulation observed in normal weight women with polycystic ovary syndrome. |
| 12213898 |
improves insulin resistance by GH-dependent and independent mechanisms |
| 12111701 |
is positively associated with benign prostatic hyperplasia risk |
| 12237896 |
Circulating levels of insulin-like growth factor-I and risk of ovarian cancer |
| 11896491 |
study indicated a negative correlation between IGF-I levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-I levels after an exercise intervention |
| 15350139 |
Data confirm the involvement of the insulin-like growth factor binding protein (IGFBP)-binding domain on IGF-1 in binding to IGFBP-2 and IGFBP-3 and support involvement of the IGF-1 receptor-binding domain in IGFBP binding. |
| 16015705 |
Imbalance of IGF-1 and IGFBP-3 may play a role in hepatocarcinogenesis and tumor development of liver cirrhosis patients |
| 14714750 |
"Growth hormone(GH)regulates IGF-1 gene expression in a variety of tissues, including...liver...and skeletal muscles...effects of GH on IGF-1 gene transcription...depend(s)on GH availability, but also on expression of the GH receptor..." p. 1273 |
| 15134305 |
P. 445: "The concentration of IGF-I in maternal plasma is correlated to fetal growth." |
| 15302288 |
Long-term use of both conjugated equine etrogens and raloxifene decreases serum IGF-I and the IGF-I/IGFBP-3 ratio |
| 15302582 |
IGF-1-induced hypertrophy can involve the recruitment of reserve cells in human skeletal muscle. |
| 14684598 |
IGF-I-induced activation of the skeletal alpha-actin promoter is regulated by the L-type VGCC and calcineurin but independent of nuclear factor of activated T-cell transcriptional activity as C2C12 myoblasts differentiate into myotubes. |
| 12948293 |
growth disorders in this group of children might be due to a defect in a DNA region regulating expression of the growth hormone receptor and insulin-like growth factor 1 genes or genes involved in their regulation. |
| 12949013 |
Exercise-associated mechanisms may inhibit increases in IGF-I early in the course of a training protocol, even in overfed subjects. |
| 14764950 |
In human fetuses, IGF-I and IGF-II levels increase longitudinally throughout pregnancy. |
| 11907830 |
IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1. |
| 15625284 |
Increased circulating IGF-1 and IGFBP-3 may be stimulators of atherosclerosis. |
| 14744783 |
IGFBP-3 plays a crucial role in regulating IGF-I bioavailability, promoting cell survival. |
| 15211595 |
IGF-1 may protect from hyperglycemia-induced oxidative stress and neuronal injuries by regulating mitochondrial membrane potential, possibly by the involvement of UCP3. |
| 15784711 |
Effect pf genetic and environmental factors on levels in female twins in puberty. |
| 15844470 |
Critically ill children are characterized by low levels of IGF-I and -II as well as IGFBP-3 accompanied by elevated levels of GH, probably reflecting the development of peripheral GH resistance. |
| 16041536 |
Environmental factors have profound effects on circulating IGF system components and on the relationship between IGFBP-1, IGF-I and related metabolic variables such as glucose tolerance. |
| 16115888 |
PAPP-A increased the proliferation and differentiation of myoblasts, its myogenic effect is governed by its proteolytic activity, and it promotes skeletal myogenesis by increasing the amount of free IGFs. |
| 14681231 |
results establish that tumor necrosis factor alpha targets insulin-like growth factor-I induced E2F-transcription facor 1 synthesis, leading to inhibition of accumulation in cyclin A and hyperphosphorylation of RB protein |
| 11988840 |
IGF-1 inscribes a gene expression profile relevant to cancer progression |
| 15358562 |
effect on heat shock protein-90 signaling |
| 15345670 |
endogenous expression of SR-BI/CLA-1 was suppressed by exposure to growth hormone or IGF-I in cultured HepG2 cells |
| 15956340 |
C-domain of IGFBP-2 plays a key role in binding regions of IGF-I and -II that are also involved in binding to the type-1 IGF receptor |
| 16400188 |
the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer |
| 16645019 |
variant carriers have a higher risk for cardiovascular disease than carriers of the wild type when they develop an abnormal glucose tolerance |
| 16888814 |
IGFs co-activate proliferative and apoptotic pathways in LIM 1215 cells, which may contribute to increased cell turnover. |
| 16935391 |
High plasma levels of IGF-1, IGF-2, and IGFBP-3 were associated with good prognosis in patients with advanced NSCLC. |
| 17300730 |
Common genetic variation in IGF1 is strongly associated with percentage mammographic density |
| 17376820 |
Our results suggested a potential effect of SNP3 in the IGF1 gene on age at menarche variation in Caucasian women for the first time. |
| 17396438 |
We demonstrated that children with sickle cell anemia have abnormalities in the IGF-I axis, which worsen with age. |
| 17509524 |
IGF-1 expression is activated by hypoxia through STAT5b in human HepG2 cells |
| 12865482 |
Divergent influences of sex steroids, IGF-1, and IGFBP3 on age-related changes in lean body mass in healthy elderly men and women. |
| 12943991 |
role of ERK1 and 2 in mediating IGF-I-stimulated vascular smooth muscle cell proliferation and chemotaxis |
| 12424437 |
analysis of single and double targeted mutagenesis of the gene encoding IGF-I demonstrate its critical role in embryonic development-REVIEW |
| 12612059 |
Inhibition of either phosphatidylinositol 3-kinase (PI3-K) or Mek1/2 signaling pathways completely abrogated the IGF-I-induced increase in VEGF secretion and promoter activity |
| 15033176 |
Recombinant human IGF-I promotes G1 progression in oligodendrocyte progenitor cells by enhancing FGF-2 induction of cyclin D1, activation of G1 cyclin-cyclin-dependent kinase complexes, and hyperphosphorylation of retinoblastoma protein. |
| 15087580 |
a decrease of insulin-like growth factor 1 along with an increase of hepatocyte growth factor may reflect an underlying biological process that influences cognitive decline as well as carotid atherosclerosis in the elderly |
| 11787050 |
induces Pin1 expression in promoting cell cycle S-phase entry |
| 11904589 |
The insulin-like growth factor-I gene cytosine-adenine polymorphism relates with circulating insulin-like growth factor-I levels and bone mineral density at the lumbar spine and proximal femur. |
| 15044591 |
GH and IGF-I can synergize in acute aspects of signaling and IGF-I enhances GH-induced assembly of conformationally active GHRs |
| 15105834 |
IGF-I prevents apoptosis by preventing downstream caspase activation, maintaining Delta Psi(M) and regulating Bcl proteins. |
| 12891709 |
inactivation of FoxO1 by IGF-I plays a critical role in rat skeletal satellite cell proliferation through regulation of p27Kip1 expression |
| 15072640 |
This review outlines the pathways by which IGF-1 affects multiple layers of the regenerative response and how these pathways converge to promote the regeneration of peripheral nerves. |
| 15331555 |
Vitreous samples from patients lacking diabetes or other retinal pathology had undetectable or low activities to IGF1 |
| 15611085 |
RACK1 has a scaffolding function and regulates adhesion and insulin-like growth factor I signals that are necessary to regulate Akt activity and to promote turnover of focal adhesions and cell migration |
| 11903419 |
assess the levels of IGF1 during pregnancy and to determine whether or not low concentrations are associated with fetal untrauterine growth retardation |
| 12102164 |
Elevated levels of IGF-1 is associated with pleural effusions of solid tumors |
| 12861174 |
serum concentrations of insulin-like growth factor binding protein-1 are abnormal in antiphospholipid syndrome pregnancies |
| 15205474 |
The C and D domains of IGF-II promote higher affinity binding to the IR-A than the equivalent domains of IGF-I. |
| 15731363 |
IGF-I deficiency is part of the underlying mechanism of diminished islet growth in GHR(-/-) mice and are consistent with the notion that IGF-I mediates growth hormone-induced islet cell growth. |
| 15797461 |
The IGF1(70 amino acids) is single-chain polypeptides structurally similar to proinsulin. |
| 15954927 |
In sedentary, clinically stable maintenance hemodialysis patients as compared to sedentary normal individuals, the mRNA levels for IGF-IEa, IGF-II, and the IGF-I receptor are decreased in vastus lateralis muscle |
| 16776662 |
IGFBP-1, IGFBP-3 and IGF-I show acute changes following a glucose load and there are marked gender differences in these responses. |
| 16942485 |
IGF-1 is more potent in inducing the survival of vascular smooth muscle cells from asymptomatic patients as compared to that of symptomatic subjects. |
| 16953217 |
Forced RIZ1 expression in CML-BC cell lines decreases IGF-1 receptor activation |
| 16962112 |
Differential expression of insulin receptor, IGF-IR, and IGF-I in adhesion fibroblasts may contribute to pathogenesis of fibrosis in diabetic patients. |
| 17113753 |
circulating levels may be lowered in patients with head and neck cancer |
| 17119061 |
plasma levels of IGF1 and IGFBP-3 vary by ethnic group and have roles in development of obesity |
| 17320297 |
inhibition of signal transduction pathways common to growth factors such as igf1 appears as a challenge to glioblastoma multiforme inhibition studies. [TRVIEW] |
| 17320874 |
Bioavailability of IGF-I appears to play a key role in oocyte maturation in patients with polycystic ovary syndrome. |
| 12095637 |
MGF inhibits terminal differentiation and increase cell proliferation of myoblast (mechano growth factor) |
