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IGF1R


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Symbol:IGF1R
Name(s):insulin-like growth factor 1 receptor
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18059487 UVB irradiation leads to an activated p38 MAPK that is regulated in an IGF-1R-dependent manner, leading to NF-kappaB p50:RelA/p65 activation and a survival phenotype.
18249219 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18316725 Observational study of gene-disease association. (HuGE Navigator)
18349294 Observational study of gene-disease association. (HuGE Navigator)
18050122 The results do not support the association of the most prevalent insulin-like growth factor I receptor gene polymorphism and the risk of advanced retinopathy of prematurity.
14657428 Observational study of gene-disease association. (HuGE Navigator)
15043778 Observational study of gene-disease association. (HuGE Navigator)
15127203 Observational study of gene-disease association. (HuGE Navigator)
15181035 Observational study of gene-disease association. (HuGE Navigator)
16362313 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDc-src tyrosine kinaseinsulin-like growth factor 1 receptor precursor--Pubmed
HPRDc-src tyrosine kinaseinsulin-like growth factor 1 receptor precursor--Pubmed
BINDc-src tyrosine kinaseinsulin-like growth factor 1 receptor precursorCSK interacts with IGF-IR.-Pubmed
HPRDguanine nucleotide binding protein, alpha inhibiting activity polypeptide 1insulin-like growth factor 1 receptor precursor--Pubmed
HPRDguanine nucleotide binding protein, alpha inhibiting activity polypeptide 1insulin-like growth factor 1 receptor precursor--Pubmed
HPRDGNAI2insulin-like growth factor 1 receptor precursor--Pubmed
HPRDguanine nucleotide binding protein, alpha inhibiting activity polypeptide 2IGF-I receptor--Pubmed
BINDgrowth factor receptor-bound protein 10 isoform cinsulin-like growth factor 1 receptor precursorGrb10 interacts with IGFIR.-Pubmed
HPRDgrowth factor receptor-bound protein 10insulin-like growth factor 1 receptor precursor--Pubmed
HPRDgrowth factor receptor-bound protein 10insulin-like growth factor 1 receptor precursor--Pubmed

Recent Publications on IGF1R:

Pubmed Logo
Sequence variation in IGF1R is associated with differences in insulin levels in nondiabetic Old Order Amish.
BACKGROUND: Insulin growth factor-1 receptor (IGF1R) encodes the...
31st October, 2009
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Diabetes Metab Res Rev. 2009 Oct 29;25(8):773-779.
DOI Direct Link
Two Short Children Born Small for Gestational Age with Insulin-Like Growth Factor 1 Receptor Haploinsufficiency Illustrate the Heterogeneity of Its Phenotype.
Context: Small for gestational age (SGA)-born children comprise a...
30th October, 2009
Department of Pediatrics, Subdivision of Endocrinology, Erasmus Medical J Clin Endocrinol Metab. 2009 Oct 28.
DOI Direct Link
Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone-An array comparative genomic hybridization study.
Very little is known about the genetics of fibrosarcoma (FS) of bone. We...
29th October, 2009
Department of Pathology, Haartman Institute and HUSLAB, University of Genes Chromosomes Cancer. 2009 Oct 27.
DOI Direct Link
Insulin Receptor and IGF1R Are Not Required for Oocyte Growth, Differentiation, and Maturation in Mice.
In mammals, insulin and insulin-like growth factors (IGFs: IGF1 and IGF2)...
24th October, 2009
Department of Genetic Medicine and Development, University of Geneva Sex Dev. 2009 Oct 23.
DOI Direct Link
Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers.
ABSTRACT: INTRODUCTION: Women who carry mutations in BRCA1 and BRCA2 have...
22nd October, 2009
Breast Cancer Res. 2009 Oct 20;11(5):R76.
DOI Direct Link

View more research publications.

Press Releases on IGF1R:

BioPortfolio Logo
Pipeline for Breast Cancer Therapies is Focus of New MedPredict Report 27th August, 2008 MedPredict

SCOTTSDALE, Ariz., Aug. 27 /PRNewswire/ -- MedPredict has published a new report in its oncology series entitled "Thought Leader Insight & Analysis: Breast Cancer," designed to

BioNews Results for IGF1R

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BioPortfolio Logo
Polymorphisms in the IGF1 signalling pathway including the myostatin gene are associated with left ventricular mass in male athletes [Original article]
British Journal of Sports Medicine:  Oct 1 2009 1:54AM Matching: igf1r

Clinical Trials:

Clinical Trials Logo
Retrospective Study Evaluating IGF1R And p95HER2 as Prognostic Factors in Non Small Cell Lung Cancer (NSCLC)

Patents:

Patents logo
US Patent No.Title
7452537 P-cadherin antibodies
7526387 Expression profile algorithm and test for cancer prognosis
7527787 Multivalent immunoglobulin-based bioactive assemblies
7528147 Pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors
7534792 Pyrrolotriazine kinase inhibitors

View more patents.

IGF1R results (if any) from reagent suppliers

Google CSE Logo
IGF1R Antibody IGF1R
IGF1R antibody was produced against recombinant fragment of the cytoplasmic domain of human IGF-1R β-subunit expressed in E. coli. ,
http://www.prosci-inc.com/shop/catalog1/IGF1R-Antibody-p-551...

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IGF1 Receptor (IGF1R) Antibody (C-term)
Western blot analysis of anti-IGF1R Pab (Cat. #AP7649b) in SK-BR-3 cell lysate. IGF1R (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was ...
http://www.abgent.com/products/catalog_no/AP7649b_IGF1_Recep...

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IGF1R antibody, IGF-1R (Phospho-Tyr1161) Antibody, Rabbit ...
Buy quality rabbit IGF1R antibody (interacts with human mouse rat), anti-IGF1R, IGF-1R (Phospho-Tyr1161) antibody, rabbit polyclonal antibody, IGF-1R ...
http://www.genwaybio.com/product_info.php?products_id=210214...

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IGF1 Receptor (IGF1R) Antibody (N-term)
Western blot analysis of anti-IGF1R Antibody (N-term) (Cat.#AP7649a) in SK-BR-3 cell line lysates (35ug/lane). IGF1R (arrow) was detected using the purified ...
http://www.abgent.com/products/catalog_no/AP7649a_IGF1_Recep...

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IGF1R antibody, IGF-Ir Antibody, Mouse Monoclonal Antibody
Buy quality mouse IGF1R antibody (interacts with n/a), anti-IGF1R, IGF-Ir antibody, mouse monoclonal antibody, IGF-Ir Antibody, Mouse Monoclonal Antibody
...
http://www.genwaybio.com/product_info.php?products_id=240488...

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CD221 Antibody Insulin-like growth factor 1 receptor
Application. IGF1R antibody can be used for the detection of IGF1R by Western blot, may also work for IHC and ICC. Tested Application. WB. Buffer ...
http://www.prosci-inc.com/shop/catalog1/CD221-Antibody-p-166...

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IGF1 receptor antibody, IGF1 receptor [alphaIR3] Antibody, Mouse ...
Mouse monoclonal [alphaIR3] to IGF1 Receptor; CD221; IGF 1R; IGF1R; IGFIRC; Insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor ...
http://www.genwaybio.com/product_info.php?products_id=191346...

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