Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18059487 |
UVB irradiation leads to an activated p38 MAPK that is regulated in an IGF-1R-dependent manner, leading to NF-kappaB p50:RelA/p65 activation and a survival phenotype. |
| 18249219 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18316725 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18349294 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18050122 |
The results do not support the association of the most prevalent insulin-like growth factor I receptor gene polymorphism and the risk of advanced retinopathy of prematurity. |
| 14657428 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15043778 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15127203 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15181035 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16362313 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16886151 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16983186 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17044098 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17063263 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17164371 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17442315 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17898946 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17972051 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18095062 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18095062 |
IGF-I receptor gene G3174A polymorphism is associated with lumbar spine BMD in postmenopausal Korean women |
| 17560756 |
the two systems, TRs and IGF1/IGF1R could be functionally associated. |
| 17568996 |
Dual targeting of IGF-1R and PDGFR increased cell death in both glioma 18 and glioma 38 cell lines in comparison to inhibition of either receptor alone. In addition, co-inhibition of IGF-1R and PDGFR increased radiosensitivity in 18 cells. |
| 17975158 |
Blocking Hsp90 disrupts IGF-I and IL-6-induced proangiogenic signaling cascades by targeting IGF-IR and STAT3 in pancreatic cancer |
| 17918158 |
curcumin and FOLFOX work through attenuation of the EGFR and IGF-1R signaling pathways |
| 17766039 |
Data suggests that the IGF-IR gene is a physiologically relevant downstream target for BRCA1 action. |
| 17761519 |
Inhibition of IGF1R using a blocking antibody or lentivirus-delivered shRNA reduced hESC self-renewal and promoted differentiation |
| 17066319 |
the expression of IGF-I and IGFIR genes may undergo substantial change over the course of breast tumorigenesis, and the pattern of changes may be associated with breast cancer prognosis |
| 17724138 |
Data show that aldosterone increases elastin production via a mineralocorticoid receptor-independent pathway involving insulin-like growth factor-I receptor signaling. |
| 17846171 |
The apoptosis of DNA-damage-induced p53 is reduced in Igf-1r(-/-) mouse embryonic fibroblasts or tumor cells treated with the IGF-1R inhibitor. Furthermore inhibition of IGF-1R reduces p53 and Mdm2 translation through a gene-specific mechanism |
| 17486080 |
VHL inactivation leads to IGF1R upregulation, contributing to renal tumorigenesis and potentially also to chemoresistance. |
| 15921396 |
CD221 is aberrantly expressed on human myeloma cells. Higher levels of CD221 are observed in patients & human myeloma cell lines with the most aggressive 14q32 translocations. CD221 expression has a negative prognostic impact in MM patients. |
| 17640993 |
Different members of Rho GTPase family regulate IGF-II-mediated EVT cell migration differentially, depending upon whether it signals through IGF1R or in an IGF1R-independent manner. |
| 17620336 |
that endogenous IGF-1 and IGF-2 receptors can independently initiate ERK1/2 signaling and point to a potential physiologic role for IGF-2 receptors in the cellular response to IGF-2 |
| 17786320 |
Upregulation of IGF-1 receptor expression is associated with oral cancer. |
| 17418605 |
IGF-related peptides are most likely synthesized locally and might be involved in the initiation and/or progression of neointimal thickening of primary arteriovenous fistulas. |
| 17063263 |
polymorphisms in the IGF-1R and IGFBP3 genes, but not IGF-1 or IGFALS, may be associated with altered survival among subgroups of breast cancer patients defined by menopausal status |
| 17586502 |
The juxtamembrane region of IGF1R plays an important role in limiting the basal activity of the receptor. |
| 17627944 |
Insulin-like growth factor-I receptor mediates the prosurvival effect of fibronectin. |
| 17649826 |
evidence for the expression of IGF-1R in nerve sheath tumors in NF1 |
| 17634559 |
Overexpression and dimerization with EGF receptor produces a therapeutic targeet in head and neck cancer xenografts. |
| 17016438 |
Pharmacological intervention against IGF-IR with simultaneous activation of GSK3beta could be highly effective against medulloblastomas |
| 17264177 |
An amino-acid-substitution mutation is postulated to be the cause of intrauterine and postnatal growth retardation in a family. |
| 17525128 |
E2 can activate a linear pathway involving the sequential activation of IGF-IR, MMP, HB-EGF, EGFR, and MAPK in MCF-7 breast cancer cells |
| 17065200 |
Luteolin inhibits IGF-1R/AKT signaling, these results provideing a new insight into the mechanisms that luteolin inhibits testicular cancer cells. |
| 17442315 |
Common SNP (GAA1013-->GAG) in the IGF1R gene may be associated with premature pubarche in children. |
| 12444079 |
WT1-p53 interactions in gene regulation |
| 15334055 |
The cyclolignan PPP efficiently inhibits phosphorylation of IGF-1R without interfering with insulin receptor activity. |
| 12105987 |
results suggest a pathway of cancer cell adaptation to the tumor microenvironment in which conditions of the environment may induce expression of IGF1R, and this subsequent overexpression of the receptor may increase cell survival in such conditions |
| 12821780 |
Mdm2 physically associates with IGF-1R and that Mdm2 causes IGF-1R ubiquitination in an in vitro assay. Mdm2 serves as a ligase in ubiquitination of the IGF-1R and thereby causes its degradation by the proteasome system. |
| 17349528 |
Intense insulin-like growth factor-1 receptor is associated with local and metastatic prostate cancer |
| 15671548 |
IGF-1R and the IGF system may have roles in progression of highly malignant soft tissue sarcoma |
| 14729630 |
Compounds with inhibitory effects on IGF-1R may be useful in development of anticancer agents. |
| 17296734 |
Overexpression of a constitutively activated IGF-IR (CD8-IGF-IR) was sufficient to cause transformation of immortalized human mammary epithelial cells and growth in immunocompromised mice. |
| 15820831 |
IGF-1 receptor was found in seminal plasma from fertile and infertile men, but no IGF-1 receptor was observed in sperm from patients with a history of more failed fertilization |
| 16328478 |
overexpression of IGF-IR exists in hematopoietic cells in myelodysplastic syndrome and acute myeloid leukemia marrows, which appears to contribute to disease progress |
| 12483226 |
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice |
| 17145858 |
Data provide evidence that an increase in IGFIR gene copy number results in aberrant expression in the blastemal compartment of some Wilms' tumors and is associated with an adverse outcome in these patients. |
| 16053920 |
We found that the colon cancer cell lines Caco2, HT29, SW837, and SW480 express high levels of the IGF-1R receptor, and that both SW837 and SW480 cells display constitutive activation of this receptor. |
| 15595626 |
IGF-I receptor signaling and function in breast cancer is modulated by estrogen receptor alpha |
| 14722023 |
Human micro- and macrovascular endothelial cells express more IGF-IR than insulin receptor. |
| 15254679 |
DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling |
| 16805964 |
IGF-1 receptor kinase is inhibited by hydrogen peroxide |
| 16831875 |
Data show that hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. |
| 17524361 |
This study suggests that the IGF-IR is a substrate for gamma-secretase and may mediate a function independent of its role as a receptor tyrosine kinase. |
| 15256055 |
Increases in IGF-IR decrease beta1 integrin expression, and enhance cell migration in neuroblastoma cells. |
| 16172123 |
CXCR4 is trans activated by IGF1R in human breast cancer epithelial cells |
| 12005306 |
cDNA probes were used to analyze the gene expression of IGF-I receptor in luteinized granulosa cells from different-sized follicles after ovarian hyperstimulation. |
| 15867218 |
IGF-IR level was lower in gastrinomas of patients who were rendered disease free and increased levels correlated with tumor growth, aggressiveness, extent, and with liver metastases. |
| 16827799 |
IGF1R overexpression might activate pERK1/2 and pAKT in hormone receptor-positive breast cancer, but activate only pAKT in hormone receptor-negative breast cancer. |
| 17014845 |
transcriptional activation of the IGF-IR gene by Cav-1 requires an intact p53 signaling pathway |
| 16362313 |
Our results do not support the hypothesis that the carrier state of IGF-IR G(+3174)A polymorphism has an impact on the risk of ROP in infants. |
| 12876069 |
Ligand activation of IGF-1R protects normal human mesangial cells from glycol-oxidant-induced apoptosis program. IGF-1R-activated ERK signaling phosphorylates Ser112 of mitochondrial Bad protein, linking IGF-1R with mitochondrial survival. |
| 11782378 |
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. |
| 12147227 |
expression at normal levels in Nijmegen breakage syndrome cells |
| 16037379 |
Existence of unidirectional IGF-IR/EGFR cross-talk mechanism whereby IGF-II, acting through IGF-IR, regulates basal and ligand-activated EGFR signaling and cell proliferation in a c-SRC-dependent manner in tamoxifen-resistant breast cancer. |
| 15932773 |
leptin and the IGF system of IGF-I, IGFBP-2, and IGF-I receptor do not interact directly in a cell culture model of neuroepithelioma cells |
| 14973173 |
Data show that differentiated thyroid cancers of children and adolescents express IGF-I and IGF-I receptors. |
| 16407661 |
Serum starvation significantly increases PDGFbeta-R but not IGF-1-R mRNA & protein expression in smooth muscle cells. Distribution of PDGFbeta-Rs & IGF-1-Rs in atherosclerotic lesions may indicate an effect of serum starvation on SMCs in arterial wall. |
| 16087727 |
interplay between WT1 and ERalpha in control of IGF-IR gene transcription |
| 12482592 |
IGF-1 receptor undergoes serine autophosphorylation and binds to 14-3-3 |
| 12884909 |
IGF binding to the IGF1R initiates an intracellular signaling cascade in breast neoplasms that leads to changes in gene expression and cell biology [review] |
| 14627343 |
role of IGF-1R and c-Src in human pancreatic carcinogenesis. Coexpression of both these molecules may play important role in transformation of pancreatic ductal cells. |
| 15638375 |
association between IGF-IR expression in the primary oral tumours and their stage |
| 14575710 |
results suggest a novel regulatory role of the C-terminus of IGF-IR in mediating cellular radioresistance that may be independent of survival signals transmitted through this receptor |
| 11867942 |
Functional insulin-like growth factor-1/insulin-like growth factor-1 receptor-mediated circuit in human and murine thymic epithelial cells. |
| 12379772 |
affects angiogenesis, growth, and metastasis of colon cancer |
| 14654552 |
Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. |
| 14697248 |
IGF-IR mediated attenuation of antineoplastic agent-induced growth inhibition is dependent on IGF-I-induced PI3K signaling rather than IGF-I-induced MAPK signaling |
| 15472208 |
hyaluronan production is induced by GD-IgG in fibroblasts suggests that the IGF-I receptor and its activating antibodies may represent a key pathway through which important pathogenic events in thyroid-associated ophthalmopathy are mediated. |
| 15564321 |
IGF-I signaling may have a role in altered fetal growth and development |
| 15623623 |
Low levels of insulin-like growth factor type 1 receptor expression at cancer cell membrane is associated with liver metastasis in colorectal cancers |
| 16181796 |
the IGF-IR gene is a novel downstream target for p63/p73 action |
| 16981720 |
These data suggest that IGF-1R and PKCdelta are required to stimulate PKB phosphorylation in response to BMOV in HepG2 cells. |
| 16981855 |
Precise orientation of IGF-I within the IGF-I-IGF-1R complex involving the IGF-I C-domain binding to the IGF-1R CR domain. |
| 14710366 |
Single chain humanized antibody treatment down-regulated IGF-IR which appears to contribute to breast tumor growth inhibition. |
| 15059221 |
All squamous cell carcinomas and basal cell carcinomas were negative for IGF-IR expression. Six of seven Merkel cell carcinomas stained with IGF-IR strongly, showing cell membrane accentuation and a perinuclear dot-like pattern. |
| 15358139 |
Data report that antagonism of the type 1 insulin-like growth factor receptor in combination with inhibitors of the epidermal growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis. |
| 14737113 |
overexpressing PTEN demonstrated that PC3 cells synthesize significantly lower levels of the IGF-IR precursor |
| 15914670 |
The function of the ELAV RNA-stability factor HuR as a 5'-UTR-binding protein and dual-purpose translation repressor may be critical for the precise regulation of IGF-IR expression. |
| 16750336 |
Weaker placental IGF-1R staining in the placentae of diabetic pregnancies associated with septal hypertrophic cardiomyopathy suggests reduced expression of IGF-1R |
| 12493743 |
IGF-IR-mediated radioresistant signaling mechanism progresses through redundant downstream pathways |
| 12937141 |
In IGF-IR dominant negative cells decrease in constitutive and inducible phosphorylation of IGF-IR and Erk1/2. Nuclear hypoxia-inducible factor-1alpha and secreted VEGF protein levels also significantly lower. |
| 14769130 |
muscarinic receptors may inhibit insulin signalling by promoting IRS-1 tyrosine dephosphorylation and/or by uncoupling IRS-1 from the stimulated IGF-1 receptor by stimulating IRS-1 serine phosphorylation |
| 15805544 |
OxLDL downregulates IGF-1R via redox-sensitive pathways that are distinct from OxLDL signaling through MAPK- and PPARgamma-involved pathways but may involve a CD36-dependent mechanism |
| 11694888 |
X ray structure and autoregulation of the insulin-like growth factor 1 receptor kinase |
| 16000560 |
Data suggest that IGF-IR may be involved in the growth of a subset of craniopharyngiomas and points to the possibility of the involvement of IGF-IR inhibitors as a treatment modality. |
| 16127155 |
Segregation of IGF-IR in and out of lipid rafts may dynamically regulate the pro- and anti-apoptotic effects of IGF-I on apoptosis induced by TNF superfamily members. |
| 12843179 |
human longevity are coregulated by an overlapping set of genes, contributing to the hypothesis that the impact of the IGF-I/insulin pathway on longevity is a property that has been evolutionarily conserved throughout the animal kingdom. |
| 12613967 |
First demonstration of insulin-like growth factor-I receptor on human ocular surface. |
| 14726697 |
PI3K/Akt and Raf/MEK/ERK pathways are intimately involved in IGF-1R-mediated cell cycle progression and prevention of apoptosis in hematopoietic cells |
| 16648580 |
PQ401 inhibits autophosphorylation ofIGF-IR in cultured human breast cancer cells with an IC50 of 12 micromol/L and phosphorylation of the isolated kinase domain of the IGF-IR. |
| 16886151 |
both IGF1R and the TGF-beta /BMP pathway could play important roles in immune function in sickle cell anemia and their polymorphisms may help identify a "bacteremia-prone" phenotype |
| 12031683 |
results suggest that activation promotes neuroblastoma cell proliferation by regulating trans-membrane amino acid transport |
| 12634644 |
Shrinkage in uterine volume induced by GnRH analogs seems to be related to reduction in IGF-I-R levels. IGF-I/IGF-I-R system might affect leiomyoma growth. Action of GnRH analogs on uterine leiomyomas might be related to the effects on IGF-I-R expression. |
| 14651979 |
These findings suggest that 14-3-3 proteins interact with the IGFIR in vivo and that this interaction may play a role in a transformation pathway signaled by the IGFIR. |
| 14710354 |
Activation of IGF-I receptor can selectively enhance the previously reported IGF-I receptor pro-apoptotic signaling pathways. |
| 14710355 |
Transcription of the IGF-IR gene is under inhibitory control by a number of transcription factors with tumor suppressor activity, including BRCA1 and p53. |
| 14710359 |
Expression in breast cancer correlates with estrogen receptors alpha ansd beta. |
| 14710360 |
IGF-IR was expressed in primary breasttumors as well as in lymph node metastases, but the expression in primary tumors was more frequent |
| 12127559 |
Autocrine production of IGF-I and IGF-II may via IGF-IR play a significant role in the growth and megakaryocytic differentiation of K562 cells. |
| 14633695 |
The IGF1-R/Akt/Bcl-x(L) pathway may contribute to a more aggressive malignant phenotype, in a subset of colorectal cancers. |
| 15689620 |
Data show that ionizing radiation causes stress-induced activation of insulin-like growth factor-1 receptor-Src-Mek-Erk-Egr-1 signaling that regulates the clusterin pro-survival cascade. |
| 16647191 |
selected examples of tumor suppressors, including BRCA1, p53, and WT1, whose mechanism of action involves regulation of IGF-IR gene expression. [REVIEW] |
| 16793764 |
Tyr-1135 plays an important role in stabilizing the autoinhibited conformation of the activation loop, while Tyr-1136 plays the key role in stabilizing the open, activated conformation of IGF1R within the tyrosine kinase catalytic domain. |
| 17277889 |
small interfering RNA for IGF-1R significantly inhibited the formation of lung metastases in nude mice. |
| 17320820 |
EGFR cannot compensate for IGF1R depletion. |
| 12644306 |
Ribonucleoprotein complex assembly on the 5'-untranslated region of the IGF-IR transcript. |
| 12138094 |
Insulin-IGF1 hybrid receptors have different tissue-specific responses based on their isoforms |
| 12138114 |
The x-ray structure of the unactivated kinase domain of insulin-like growth factor-1 receptor (IGFRK-0P) is reported here at 2.7 A resolution. |
| 14551153 |
IGF-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway. |
| 14597618 |
role of IGF1 in cardiac myocytes in the absence of secondary effects, and downstream signaling pathways and transcriptional regulatory effects of the IGF1 receptor |
| 15878855 |
beta-arrestin has a role in ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase |
| 12784091 |
Down- and up-regulation suggests that restoration of IGF-1R would be the result of receptor recycling and de novo synthesis and highlights its importance for T lymphocyte proliferation. |
| 16035620 |
high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer |
| 12820418 |
Overexpressed and activated IGF1-R may increase the degree of transformation and motility of colon cancer cells by activating c-Src. |
| 12593846 |
signaling pathways mediated by insulin-like growth factor-I receptor are required for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line |
| 15253384 |
an interrelationship is now known to exist between the IGF and EGF receptors [review] |
| 14559999 |
results suggest a novel function for the IGF-IR/IRS-1 pathway that involves regulation of the intracellular trafficking of Rad51 to the site of damaged DNA-a crucial step in the process of DNA repair by homologous recombination |
| 14764897 |
Shc and IGF-1R serve as key elements in the translocation of ERalpha to the cell membrane and in the facilitation of ERalpha-mediated rapid E2 action |
| 14744783 |
IGFBP-3 inhibits IGF-I-mediated IGF type 1 receptor (IGF-IR) phosphorylation in 3t3 cells overexpessing human IGF1R |
| 12603530 |
IGF-IR and IGF-IIR antisense genes could significantly restrain the malignant behavior of human hepatoma cells and might be useful in investigating a potential route for hepatocellular carcinoma gene therapy. |
| 14710368 |
Ability of a monoclonal antibody to down-regulate the receptor may be an important antibody property in targeting the insulin-like growth factor-I receptor for the treatment of certain cancers. |
| 15345673 |
The present data suggests that the IGF-IR gene is a novel downstream target in an ATM-mediated DNA damage response pathway. |
| 16584539 |
Breast cancer MCF-10A cells over-expressing the IGFIR formed large, misshapen acinar structures with filled lumina and disrupted apico-basal polarization. |
| 16595699 |
demonstrate significant overexpression of the IGF-IR in human pheochromocytomas |
| 16804965 |
The up-regulation of IGF-IR expression in hepatocytes of patients with CHC could constitute an attempt to stimulate hepatocyte regeneration. |
| 17097318 |
These results demonstrate that IGF1R is downregulated by P53, and that siRNA targeting of IGF1R increases liver cancer cells sensitivity to adriamycin and promotes apoptosis. |
| 14691011 |
IGF I receptor is involved in apoptosis protection in human preadipocytes and adipocytes. |
| 14615489 |
To further understand the role of the type I insulin-like growth factor (IGF) receptor (IGF1R) in cancer metastasis we inhibited signaling via IGF1R using a C-terminal-truncated IGF1R. |
| 15205474 |
Activation of IGF-1R by the chimeras reflected their binding affinities whereas the phosphorylation of the two insulin receptor isoforms was more complex. |
| 15797461 |
The IGF-1 Receptor genes has been inactivated by homologous gene targeting. |
| 15954927 |
In sedentary, clinically stable maintenance hemodialysis patients as compared to sedentary normal individuals, the mRNA levels for IGF-IEa, IGF-II, and the IGF-I receptor are decreased in vastus lateralis muscle |
| 16891453 |
IGF-IR and c-Met cooperate to induce migration and invasion of human pancreatic carcinoma cells. |
| 16962112 |
Differential expression of insulin receptor, IGF-IR, and IGF-I in adhesion fibroblasts may contribute to pathogenesis of fibrosis in diabetic patients. |
| 17196841 |
Small interferin RNA downregulates this protein and inhibits growth of a breast cancer cell line in vitro and in nude mice. |
| 17307140 |
EGFR depletion induced enhancement of IGF1R ubiquitylation and degradation. |
| 12556535 |
This receptor signals the inhibitor of apoptosis ASK1. |
