Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18287864 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15894694 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15941947 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15986122 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16030120 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16049980 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16215864 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16306136 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16404426 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16448675 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16489531 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17018785 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17035411 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17044098 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17051426 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17063263 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17289909 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17293864 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17300730 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17350302 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17546465 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17555512 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17566087 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17627014 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17724372 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17761791 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 18006928 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18031946 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18059035 |
Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18163429 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15894673 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 11238520 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11319179 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12907612 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12925957 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14693733 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15066922 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15247132 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15298948 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15668470 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15734965 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15800934 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17827406 |
E7-mediated destruction of nuclear IGFBP-3 correlates with the inhibition of IGFBP-3-induced apoptotic cell death. |
| 18084616 |
microsatellite instability in CPG-island-metahylator-high colorectal cancers, & this relationship is limited to p53-negative tumors. |
| 18177247 |
These findings suggest that serum levels of IGFBP-3 (and possibly IGF-I) are associated with the rate of HIV disease progression in women. |
| 18031946 |
no major role of the assessed genetic variation within the IGF1 and the IGFBP3 genes in CRC risk. |
| 17879951 |
In a group of older US men, a strong inverse association between IGFBP-3 and lower urinary tract symptoms was observed. |
| 17957164 |
Serum IGFBP-3 was not altered in neonates with intrauterine growth retardation. |
| 17457048 |
IGFBP-3 contributes to esophageal tumor development and progression through IGF-dependent and independent mechanisms. |
| 17724372 |
Serum levvels amd a single nucleotide polymorphism are indiative of prostate carcinogenesis. |
| 17912004 |
Osteopenia is common in children with cerebral palsy and may be associated with lower IGF-1 and IGFBP-3 levels |
| 17051426 |
Genetic variation in IGFBP3 is associated with breast cancer risk |
| 17689128 |
No significant differences in levels in fibromyalgia patients. |
| 17972510 |
This study supports the role of IGFBP-1, -3 and -7 as potential tumour suppressor genes in human breast cancer. |
| 17597108 |
large prospective study showed no overall association between the insulin-like growth factor axis and prostate cancer risk, however, IGF-1:IGFBP-3 molar ratio was related to risk for aggressive prostate cancer in obese men |
| 17560154 |
Severely deficient in a case of insulin-resistance syndrome (Rabson-Mendenhall type). |
| 17655506 |
[(125)I]-labeled IGFBP-2 and -3, but not IGFBP-1, were proteolyzed by Ca(2+)-activated m-calpain in vitro. |
| 17566087 |
Common genetic variation in IGFBP3 influences circulating levels of IGFBP-3 among African-Americans, Native Hawaiians, Japanese-Americans, Latinos, and whites. |
| 17624927 |
Insulin-like growth factor binding protein (IGFBP)-3 mRNA is more abundantly expressed in hypoxia-related inflammatory angiogenesis and recent in vivo data suggest that IGFBP-3 has direct, IGF-independent inhibitory effects on angiogenesis. |
| 17063263 |
polymorphisms in the IGF-1R and IGFBP3 genes, but not IGF-1 or IGFALS, may be associated with altered survival among subgroups of breast cancer patients defined by menopausal status |
| 17763192 |
Perturbations in the IGF/IGFBP-3 axis may be potential additional targets for pharmacological manipulation in coronary heart disease. |
| 17434920 |
IGFBP-3 and Nur77 associate in the cytoplasmic compartment in 22RV1 human prostate cancer cells. |
| 17668637 |
Men who carry the IGFBP3 C allele were found to have a higher risk of developing prostate cancer compared to controls, and the association was grade specific in both ethnic groups |
| 17635417 |
These results suggest that IGFBP3 might play an important role in the cellular senescence of human umbilical vein endothelial cells as well as in vivo aging. |
| 17264182 |
Circulating low levels of total IGFBP-3 was associated with increased risk of incident coronary events in older adults. |
| 17593323 |
A 30-kDa proteolytic IGFBP-3 fragment was isolated from third trimester pregnancy human serum and identified by amino acid sequence analysis and mass spectrometry to correspond to residues 1-212 of the parent protein. |
| 17446556 |
normal breast epithelial cells can induce apoptosis of breast cancer cells through IGFBP-3 and maspin. |
| 12011225 |
Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China. |
| 15641262 |
IGFBP-3 levels decreased significantly six months after the iodine supplementation. |
| 15641264 |
Serum IGFBP-3 levels differed significantly between pubertal developmental stages. |
| 12571851 |
quantities of IGFBP-3 produced in culture by human cartilage are small compared with the amount supplied in the form of "small complexes" from the circulation |
| 15802501 |
Although IGFBP-3 and IGFBP-5 share much structural and functional homology, they can modulate distinct apoptotic pathways in human breast cancer cells. |
| 15894694 |
Finds IGFBP3 2133C variant allele associated with lower circulating IGFBP-3 hormone levels and an increased risk of colorectal cancer. |
| 11959812 |
A possible role for insulin-like growth factor-binding protein-3 autocrine/paracrine loops in controlling hepatocellular carcinoma cell proliferation |
| 12870155 |
endurance training improves glucose disposal and increases insulin-like growth binding protein-1 and -3 in men |
| 16306136 |
IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. |
| 17388800 |
IGFBP-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms |
| 14598881 |
Upregulated with exposure to bone microenvironment and linked to TGF-beta mediated cell proliferaton |
| 15221971 |
Association between high IGF-I and IGFBP-3 levels and increased risk of breast cancer in premenopausal women. |
| 16211216 |
IGFBP-3 mediates growth suppression signals via the TGF-beta and/or retinoblastoma protein pathways in hepatocellular carcinoma |
| 15379965 |
Mutation analysis in patients with undescended testis revealed functionally deleterious mutations, which may be responsible for the abnormal phenotype in some of the patients. (review) |
| 17453001 |
Methylation of IGFBP3 may be involved in the early stages of prostate cancer development. |
| 17172410 |
results strongly suggest that IGFBP-3 expression may be a vital cell motility, migration, and proliferation factor necessary for melanoma metastasis and is an important biomarker in human melanoma |
| 12163384 |
expression increases during immortalization of cervical keratinocytes |
| 17085968 |
These results suggest that caspase-10, DR-3 and IGFBP-3 are involved in apoptosis in the preeclamptic placenta. |
| 17187018 |
exposure to hypoxia and acidosis at birth strongly correlated with a fall in IGF-1 and IGFBP-3 levels in cord blood |
| 15703779 |
dysregulation of IGFBP-3 in patients with myelodysplastic syndromes |
| 16645643 |
Both addition of IGFBP-3 protein to cell cultures or enforced expression of IGFBP-3 in the HT29 colon carcinoma cell line inhibited nuclear factor kappa B (NF-kappaB) activation in response to the induction of apoptosis by TRAIL. |
| 15047131 |
Following severe burn, a shift occurs toward a predominant Th2 phenotype. Exogenous IGF-I/IGFBP-3 treatment partially reverses this response. |
| 15086466 |
Renal cell carcinoma (RCC) expresses IGF-I and IGFBP-3 and is responsive to exogenous IGF-I stimulation. In metastatic RCC, autocrine IGF-I and IGFBP-3 stimulated and inhibited growth. IGF-I and IGFBP-3 possible treatment in advanced RCC. |
| 15140235 |
Reduced expression of IGFBP-3 in recessive dystrophic epidermolysis bullosa squamous cell carcinoma may provide a partial explanation for the aggressive behavior and poor prognosis of these tumors in this genodermatosis. |
| 15247132 |
the IGFBP3 variants was not associated independently with colon cancer, but there was an association when examined with IRS1. The risk increased 70%. |
| 17047053 |
Cleavage of IGFBP-3 in breast carcinoma tissues was correlated with ADAM28 expression levels and inhibited by treatment with ADAM inhibitor or anti-ADAM28 antibody. |
| 16189247 |
In diabetics, nonglycosylated IGFBP-3 is degraded more rapidly than glycosylated IGFBP-3. By acting as substrate for IGFBP-3 protease, nonglycosylated IGFBP-3 protects endogenous, glycosylated IGFBP-3 from degradation, allowing total IGFBP-3 to increase. |
| 16189260 |
Impacts on insulin signaling pathway to Inhibited insulin-stimulated glucose uptake independent of IGFs and through nonnuclear mechanisms. inhibited insulin-stimulated glucose uptake in omental but not s.c. adipose tissue explants. |
| 14576163 |
The metal-binding domain of IGFBP3 mediate cellular uptake and modulates apoptosis. |
| 14576164 |
Actions of IGFBP-3 are mediated by internalization via distinct endocytic pathways. |
| 15986122 |
Increased breast cancer risk in women with promoter polymorphisms in IGF1 and IGFBP3 genes, with increased risk for individuals homozygous for both polymorphisms. |
| 11751851 |
This study defines a signaling pathway for IGFBP-3 from a cell surface receptor to nuclear transcriptional activity, requiring TGF-betaRII but not dependent on the nuclear translocation of IGFBP-3 |
| 12200149 |
IGFBP-3 promoter is activated by Trichostatin A-upregulated Sp1 |
| 17287408 |
protective role of IGFBP-3 in risk of breast cancer |
| 17447118 |
Serum testosterone concentration and serum IGF-1/IGFBP-3 molar ratio are the major determinants of bone mineral density in boys at different pubertal stages. |
| 11953210 |
study the changes of plasma insulin-like growth factor -1 (IGF-1) and IGF binding protein 3 (IGFBP3) in patients with acute cerebral infarct (ACI) and acute cerebral hemorrhage (ACH) |
| 15651061 |
1,25-dihydroxyvitamin D3-induced up-regulation of IGFBP-3 is not required for the growth inhibitory effects of 1,25D in prostate cancer cells grown in serum-containing media. |
| 11948969 |
induces early apoptosis and has potential tumor suppressive effects in prostate cancer |
| 12006706 |
determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation |
| 15448002 |
Met proto-oncogene and insulin-like growth factor binding protein 3 have roles in metastasis of well-differentiated pancreatic endocrine neoplasms |
| 11784719 |
Insulin-like growth factor (IGF)-binding protein-3 mutants that do not bind IGF-I or IGF-II stimulate apoptosis in human prostate cancer cells |
| 12473575 |
Hypermethylation of IGFBP-3 promoter is associated with non-small cell lung cancer |
| 11914023 |
Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease. |
| 14674122 |
breast malignant explants showed the progesterone induced IGFBP-3/IGF-I index decrease; the decrease was most evident in malignant explants expressing progesterone receptor |
| 14751238 |
IGFBP-3 directly triggers a specific intracellular signal in MCF-7 cells |
| 14644829 |
IGFBP-3 mRna expression is increased in endometriosis, compared to normal endomatrium. |
| 12122101 |
Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer. |
| 12571183 |
Follicular fluid IGF-1 and IGFBP-3 levels were not significantly different among the groups; however, follicular fluid IGFBP-1 levels were lower in those patients with moderate/severe endometriosis |
| 15959422 |
Maternal diabetes is not associated with suppressed levels of IGFBP-1 in cord serum. |
| 15198293 |
Patients with typical Sotos syndrome show low plasma IGF-II, IGFBP-3, IGFBP-4, and increased proteolysis of IGFBP-3 in serum. |
| 12210764 |
Variable mid-region is responsible for the specific pro-apoptotic functions of IGFBP-3; phosphorylation may provide a mechanism for regulation of this action |
| 15781645 |
IGFBP-3 is a target of transcriptional repression by DeltaNp63alpha and that this repression represents a mechanism by which tumors that overexpress p63 may be protected from apoptosis. |
| 15927849 |
Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of IGFBP-3 |
| 16181731 |
Loss of insulin-like growth factor-binding protein-3 expression is associated with head and neck carcinogenesis. |
| 16275148 |
Using the rat insulinoma RINm5F cell line, we report the first studies in insulin-secreting cells that IGFBP-3 selectively suppresses multiple, key intracellular phosphorelays. |
| 16552541 |
The IGFBP3, hRas, JunB, Egr-1, Id1 and MIDA1 genes were up-regulated in psoriatic involved skin compared with uninvolved skin. |
| 16825320 |
a novel functional androgen response element is present in the IGFBP-3 promoter that directly mediates androgen induction of IGFBP-3 expression |
| 16969385 |
This study demonstrates a direct interaction of the IGF and TGF-beta systems in human renal carcinoma cells. The observations that IGF-I enhances the TGF-beta signaling and that TGF-beta promotes IGFBP-3 production |
| 17210081 |
the expression level of IGFBP3 in breast tissues may be involved in breast tumorigenesis |
| 17434446 |
The role of GalNAc-T14 as an intracellular mediator of the effects of IGFBP-3 need to be verified in future studies. |
| 12519841 |
data demonstrate for the first time that serum levels of IGFs (including free fractions) and IGFBPs are not increased in euthyroid Graves' patients with active thyroid eye disease |
| 12926118 |
During Tamoxifen treatment, IGFBP-3 proteolysis was increased in breast cancer. |
| 12219010 |
HT29 tumor cell proliferation in vitro was due, at least in part, to surgery-related depletion of insulin-like growth factor binding protein 3 in peripheral blood. |
| 12508918 |
IGFBP-3 concentration significantly lower in acute ischemic stroke than in controls. |
| 12150454 |
high levels of IGFBP-3 predicted distant recurrence but not death in postmenopausal breast cancer patients and those with estrogen receptor-positive tumors |
| 15517912 |
The serum IGF-1 and IGFBP-3 levels were significantly elevated in esophageal cancer patients and there was a positive correlation between IGF-1 and IGFBP-3. |
| 15817480 |
IEE (IGFBP-3 enhancer element) is a positive transcription regulatory element that contributes to the up-regulation of IGFBP-3 during cellular senescence |
| 16489075 |
IGFBP-3 expression was higher in less aggressive tumors, but was not associated with disease progression. |
| 16965600 |
Low expression of IGFBP-3 is associated with hepatocellular carcinoma |
| 11914026 |
Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly. |
| 12051736 |
Enhanced expression in gastric cancer cells increases paclitaxel and etoposide-induced growth inhibition |
| 12937269 |
IGFBP-3 degrading by MMP might have widespread consequences for the behavior of epidermal keratinocytes. |
| 12962157 |
IGFBP-3 can bind to LTBP-1 and provide a potential mechanism whereby IGFBP-3 can interact with the TGF-beta system |
| 15014034 |
an important additional prognostic marker in serum in ovarian cancer |
| 14561895 |
functional effects of Humanin-IGFBP-3 interaction on cell survival and apoptosis |
| 15069073 |
IGFBP-3 is phosphorylated by tissue transglutaminase 2 |
| 12725526 |
IGFBP-3 mRNA and protein are differentially expressed in distinct human brain microvascular endothelial cells populations. |
| 12135130 |
circulating level of IGFBP3 is related to the extent of myocardial injury in patients with hypertrophic cardiomyopathy. |
| 15661050 |
The expression of certain IGFBP is significantly altered in renal cell carcinoma |
| 15681824 |
Insulin-like growth factor binding proteins 3 and 5 are xpressed in idiopathic pulmonary fibrosis and have a role in extracellular matrix deposition |
| 15769996 |
DNA damage and hypoxia are two important physiologic activators of p53. |
| 12068000 |
Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer. |
| 12220677 |
These results provide evidence that a specific intracellular signal is triggered by IGFBP-3 binding to a cell surface receptor. |
| 15485880 |
N- and C-terminal residues of IGFBP-3 have roles in regulating IGF complex formation and receptor activation |
| 16322329 |
IGFBP-3 is differentially expressed between stromal and epithelial components of normal and malignant colon, which may reflect its pro-apoptotic, IGF-I-independent effect on colonic epithelial cells. |
| 16614079 |
IGFBP-3 has positive or negative effects on growth and survival dependent upon the status of cholesterol-stabilized integrin receptor complexes |
| 16887362 |
A decrease in free insulin-like growth factor 1 and IGFBP-3 levels, along with increases in blood pressure, significantly influenced the presence of diabetic complications |
| 16915540 |
Blood level is not a marker for metabolic syndrome x. |
| 17035411 |
Common genetic variation in the IGFBP3 gene does not substantially influence prostate and breast cancer susceptibility. |
| 17070193 |
High IGF-II, IGFBP-3, IGFBP-4, and low PAPP-A levels in FF at the time of oocyte retrieval suggest better oocyte maturation and early embryo development. |
| 17297462 |
CDX2 can function as a transcriptional repressor, and one mechanism by which CDX2 promotes anchorage-independent growth is by transcriptional repression of IGFBP-3. |
| 12590636 |
Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts. |
| 12810533 |
isolated amino-terminal and carboxyl-terminal domains of IGFBP-3 cooperate in the presence of IGFs to form high-affinity complexes that retain the ability to block IGF activity. |
| 14710345 |
an apparent altered regulation of local IGFBP-3 production during malignancy |
| 12054563 |
The amino-terminal region induces apoptosis of MCF-7 breast carcinoma cells. |
| 11762714 |
Hypothyroidism is associated with significant reductions of IGFBP-3 |
| 15282325 |
These findings identify the repression of insulin-like growth factor binding protein 3 gene by EWS/FLI-1 as a key event in the development of Ewing's sarcoma. |
| 15809062 |
PTEN may inhibit antiapoptotic IGF actions not only by blocking the IGF-IGFR-induced Akt activity, but also by regulating expression of components of the IGF system, in particular, upregulation of IGFBP-3 |
| 16543235 |
there are several conserved residues in the IGFBP-5 N-terminal region that are critical for transactivation and IGFBP-2 and -3 also have strong transactivation activity in their N-domains |
| 16541420 |
C4-2 cell survival in an androgen-depleted environment may be facilitated through differential resistance to the apoptotic effects elicited by IGFBP-3 |
| 17096329 |
Results showed that IGFBP-3 methylation played an important role in the silencing of its expression, suggesting that IGFBP-3 may act as a tumor suppressor gene in several human cancers examined. |
| 17237715 |
IGFBP-3 has potent insulin-antagonizing capability and suggest a role for IGFBP-3 in cytokine-induced insulin resistance and other mechanisms involved in the development of type-2 diabetes. |
| 11886859 |
interaction with STAT-1 during chondrogenesis |
| 11997031 |
identification of the proteolytic cleavage sites in circulating IGFBP-3 |
| 12907612 |
The IGFBP-3 -202 A/C polymorphism was not associated with susceptibility to prostate cancer. |
| 15070968 |
Interaction between IGFBP-3 and EGF receptor system is central to whether IGFBP-3 acts as growth stimulator or inhibitor in breast cancer cells. Therapies targeting EGFR may have increased efficacy in breast tumors expressing high levels of IGFBP-3. |
| 15126567 |
Pregnancy-proteolyzed IGFBP-3, despite forming normal ternary complexes, is less effective than intact IGFBP-3 in retarding IGF egress from the circulation. |
| 15178549 |
endogenous IGFBP-3 directly inhibits proliferation of human intestinal smooth muscle cells by activation of TGF-betaRI and Smad2, an effect that is independent of its effect on IGF-I-stimulated growth. |
| 15642160 |
Increased breast epithelial IGFBP-3 expression is a feature of tumorigenesis with cytoplasmic immunoreactivity in the absence of significant nuclear localisation in IDCs and DCIS; IGFBP-3 suggested to be a potential mitogen |
| 15642732 |
plasminogen binds with high affinity to IGF-II and IGF-binding protein-3 |
| 15987847 |
IGF BP3 was associated with birth weight as measured in seconsd semestser amniotic fluid. |
| 16210470 |
insulin-like growth factor signaling is subject to negative regulation through IGF binding protein-3 and positive regulation by EGF |
| 16455777 |
Rpb3 is a potential nuclear target of insulin-like growth factor binding protein-3 |
| 15067329 |
Down-regulation of IGFBP-3 gene expression is associated with Prostatic Neoplasms |
| 12213898 |
improves insulin resistance by GH-dependent and independent mechanisms |
| 12111701 |
is inversely associated with benign prostatic hyperplasia risk |
| 16015705 |
Imbalance of IGF-1 and IGFBP-3 may play a role in hepatocarcinogenesis and tumor development of liver cirrhosis patients |
| 15302288 |
Long-term use of both conjugated equine etrogens and raloxifene decreases serum IGF-I and the IGF-I/IGFBP-3 ratio, but raloxifene increases ISGFBP-3. |
| 12242693 |
role in breast cancer cell growth - review |
| 15625284 |
Increased circulating IGF-1 and IGFBP-3 may be stimulators of atherosclerosis. |
| 14744783 |
IGFBP-3 plays a crucial role in regulating IGF-I bioavailability, promoting cell survival. |
| 15844718 |
The level of intact IGFBP-3 is decreased in inflammatory bowel disease with moderate to severe disease activity. This decrease may be linked to altered IGFBP-3 production or to increased cleavage by proteases other than MMP-9. |
| 15298948 |
IGFBP3 polymorphism maybe associated with the level of blood IGFBP3 protein and an increase risk of breast cancer. |
| 16617154 |
IGFBP-3 is a growth inhibitor molecule (news) |
| 16763062 |
results indicate a previously unrecognized and potentially important role for insulin-like growth factor binding protein 3(IGFBP-3) in the extracellular matrix |
| 16793770 |
IGFBP-3 can induce apoptosis in an IGF-independent manner without being secreted or concentrated in the nucleus |
| 16935391 |
High plasma levels of IGF-1, IGF-2, and IGFBP-3 were associated with good prognosis in patients with advanced NSCLC. |
| 17056474 |
IGFBP-3, IGFBP-4, and IGFBP-10/CYR61 mRNA levels were up-regulated in Barrett's and tumour tissue of oesophageal adenocarcinoma patients |
| 17396438 |
children with sickle cell anemia with poor growth had significantly more proteolyzed IGFBP-3 in serum compared to children with normal growth |
| 17567756 |
IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. |
| 11940579 |
Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase |
| 12865482 |
Divergent influences of sex steroids, IGF-1, and IGFBP3 on age-related changes in lean body mass in healthy elderly men and women. |
| 11971816 |
IGFBP-3 is essential for TNF-alpha-induced apoptosis in PC-3 cells |
| 12599210 |
IGFBP-3 supports myoblast differentiation |
| 15247904 |
interference with Sp-1 transactivation by MeCP2 may contribute to the transcriptional defect of IGFBP-3 expression in NSCLC cells with methylated promoter |
| 16394092 |
IGF-I and IGFBP-3 levels were positively associated with weight gain and height gain from birth to 3 months in small for gestational weight versus appropriate weight children. |
| 16723126 |
By Northern blot, we confirm hypoxia-induced expression of insulin-like growth factor binding protein 3 (igfbp3), thioredoxin-interacting protein (txnip), neuritin (nrn1). |
| 16775172 |
High levels of IGFBP-3 is associated with an increased risk of prostate cancer |
| 16776662 |
IGFBP-1, IGFBP-3 and IGF-I show acute changes following a glucose load and there are marked gender differences in these responses. |
| 17113753 |
circulating levels may be lowered in patients with head and neck cancer |
| 17119061 |
plasma levels of IGF1 and IGFBP-3 vary by ethnic group and have roles in development of obesity |
| 16540651 |
an IGFBP-3 mutant with deleted leader sequence localizes within the nucleus, its abundance is regulated by the ubiquitin/proteasome pathway, nuclear IGFBP-3 can induce apoptosis |
| 14597676 |
LRP1 is the type V TGF-beta receptor and mediates growth inhibition by IGFBP-3 |
| 7566179 |
p53 induces the growth inhibitor IGF-binding protein 3 in apoptosis. |
| 11804742 |
The upstream AP2-binding site of IGFBP3's promoter is specifically hypermethylated in hepatomas. |
| 12925957 |
Polymorphic variation in IGFBP3 is associated with breast cancer risk. |
