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APP
| Symbol: | APP | | Name(s): | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17945434 |
The activation of muscarinic acetylcholine receptors, PKC and MAP kinase is involved in Hup A-induced alphaAPPs secretion in neuroblastoma cells and suggest multiple pharmacological mechanisms of Hup A regarding the treatment of Alzheimer's disease (AD). |
| 18284028 |
Findings indicate Amyloid beta protein is associated with cognitive function, body fat and physical fitness in neurologically healthy older adults |
| 17694066 |
Soluble circulating LRP (sLRP) provides key endogenous peripheral 'sink' activity for amyloid beta in humans. |
| 18184372 |
Motor strength was considerably reduced in APP transgenic mice. Neurological impairments showed by APP mice had an early onset and worsened with progressive aging, in parallel to gradual accumulation of Abeta in brain. |
| 11568920 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12433268 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 12782964 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12925374 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 14769392 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15975068 |
Observational study of genotype prevalence. (HuGE Navigator) | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | alpha-1-antichymotrypsin, precursor | amyloid beta A4 protein precursor, isoform a | - | - | Pubmed |
| HPRD | alpha-1-antichymotrypsin, precursor | amyloid beta A4 protein precursor, isoform a | - | - | Pubmed |
| HPRD | serpin peptidase inhibitor, clade A, member 3 precursor | amyloid beta A4 protein precursor, isoform a | - | - | Pubmed |
| HPRD | v-abl Abelson murine leukemia viral oncogene homolog 1 isoform a | amyloid beta A4 protein precursor, isoform a | - | - | Pubmed |
| HPRD | v-abl Abelson murine leukemia viral oncogene homolog 1 isoform a | amyloid beta A4 protein precursor, isoform a | - | - | Pubmed |
| HPRD | Acetylcholinesterase | amyloid beta A4 protein precursor, isoform a | - | - | Pubmed |
| HPRD | acetylcholinesterase isoform E4-E5 precursor | Amyloid beta A4 protein | - | - | Pubmed |
| HPRD | MINT1 | amyloid beta A4 protein precursor, isoform a | - | - | Pubmed |
| BIND | x11 protein | amyloid beta A4 protein precursor, isoform b | APPswe interacts with X11-alpha. | - | Pubmed |
| BIND | x11 protein | amyloid beta A4 protein precursor, isoform c | Beta-APP interacts with X11. | - | Pubmed |
Recent Publications on APP: |  |
Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia.
It is widely known that exogenous formaldehyde exposure induces human... | 3rd November, 2009
| State Key Lab of Brain and Cognitive Sciences, Institute of Biophysics,
| Neurobiol Aging. 2009 Oct 28.
DOI Direct Link |
Dietary apple polyphenols have preventive effects against lengthening contraction-induced muscle injuries.
We examined whether polyphenols from dietary apple have protective effects... | 30th October, 2009
| Department of Exercise Physiology, Graduate School of Health and Sport
| Mol Nutr Food Res. 2009 Oct 28.
DOI Direct Link |
Alcadein cleavages by APP {alpha}-and {gamma}-secretases generate small peptides p3-Alcs indicating Alzheimer disease-related {gamma}-secretase dysfunction.
Alcadeins (Alcs) constitute a family of neuronal type I membrane proteins,... | 30th October, 2009
| Hokkaido University, Japan;
| J Biol Chem. 2009 Oct 28.
DOI Direct Link |
Span and Tween neutral and pH-sensitive vesicles: characterization and in vitro skin permeation.
The aim of this work was the preparation, characterization, and comparison... | 30th October, 2009
| Department Of Chimica e Tecnologie del Farmaco, University of Rome
| J Liposome Res. 2009;19(4):332-40.
DOI Direct Link |
Amyloid precursor protein expression is induced by tumor necrosis factor alpha in 3T3-L1 adipocytes.
Amyloid precursor protein (APP) has been characterized as an... | 29th October, 2009
| Department of Internal Medicine III, University of Leipzig, 04103 Leipzig,
| J Cell Biochem. 2009 Oct 27.
DOI Direct Link |
→View more research publications. |
Press Releases on APP:
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| Arnold & Itkin Announces Lawsuits Over Defective Pain Pumps |
11th November, 2009 |
Arnold & Itkin |
HOUSTON, Nov. 11 /PRNewswire/ -- The Houston trial law firm Arnold & Itkin LLP has filed five lawsuits against the makers of pain
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| Reportlinker Adds Contract Pharmaceutical Manufacturing, Research and Packaging |
3rd November, 2009 |
Reportlinker |
NEW YORK, Nov. 3 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue.
FDA Alert: New USP Standards for Heparin Products Will Result in Decreased Potency |
1st October, 2009 |
U.S. Food and Drug Administration |
Adjustments may be needed to achieve desired anticoagulant effect in some patients
New Heparin to Ship Starting October 8
SILVER SPRING, Md.,
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| ROCK STARS OF SCIENCE: Prana's Co-Founding Scientist, Rudy Tanzi Teams up with Star-Powered Cast in GQ Photoshoot |
18th May, 2009 |
Prana Biotechnology Limited |
- GQ Magazine Pays Tribute to America's Top Research Scientists -
- Also Featured Jeffrey Cummings, Chair of Prana's Biotechnology Research &
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| New Poll Shows Strong Support for Conscience Rights in Health Care |
8th April, 2009 |
U.S. Conference of Catholic Bishops, Secretariat for Pro-Life Activities |
WASHINGTON, April 8 /PRNewswire-USNewswire/ -- A nationwide poll conducted on March 23-25 found that 87 percent of adults surveyed believe it is important to "make sure that healthcare
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APP results (if any) from reagent suppliers | 
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Resources from the NCBI used on this page, NCBI's standard disclaimer applies.
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