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KLK3


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Symbol:KLK3
Name(s):kallikrein-related peptidase 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:APS, KLK2A1, PSA, hK3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17593395 role of kallikrein gene 2 and 3 variant SNPs in the etiology of prostate cancer among men of European ancestry
17894328 docking studies elucidated the molecular details of the early noncovalent Michaelis complex, the acyl-enzyme covalent complex, and the nature of conformational reorganization required for the long term stability of the covalent complex.
17387315 According to our results, serum PSA levels and prostate volume in Korean SCI patients are not different from those in uninjured men and are not affected by injury characteristics.
18264097 Genome-wide association study of gene-disease association. (HuGE Navigator)
18306354 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18336535 Observational study of gene-disease association. (HuGE Navigator)
18187150 The first crystal structure of human PSA in complex with monoclonal antibody (mAb) 8G8F5 that enhances its enzymatic activity, is presented.
11299734 Observational study of gene-disease association. (HuGE Navigator)
12111704 Observational study of gene-disease association. (HuGE Navigator)
12168876 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-2-macroglobulin precursorprostate specific antigen isoform 1 preproprotein--Pubmed
HPRDalpha-2-macroglobulin precursorprostate specific antigen isoform 1 preproprotein--Pubmed
HPRDalpha-1-antichymotrypsin, precursorprostate specific antigen isoform 1 preproprotein--Pubmed
HPRDserpin peptidase inhibitor, clade A, member 3 precursorprostate specific antigen isoform 1 preproprotein--Pubmed
HPRDKallikrein 3erythropoietin receptor precursor--Pubmed
HPRDKallikrein 3fibronectin 1 isoform 3 preproprotein--Pubmed
HPRDKallikrein 3pregnancy-zone protein--Pubmed
BINDHomo sapiens prostate cancer antigen gene, promoter regionandrogen receptor isoform 1AR interacts with p-PSA.-Pubmed
BINDHomo sapiens prostate cancer antigen gene, promoter regionDNA directed RNA polymerase II polypeptide APol II interacts with p-PSA.-Pubmed
BINDHomo sapiens chromosome 19, reference assembly.-HTATIP (Tip60) interacts with the KLK3 (PSA) promoter.-Pubmed

Recent Publications on KLK3:

Pubmed Logo
A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.
Single nucleotide polymorphisms (SNPs) in the KLK3 gene on chromosome...
14th October, 2009
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Hum Genet. 2009 Oct 13.
DOI Direct Link
Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1.
In prostate cancer, the mechanism by which the stromal cells surrounding...
2nd October, 2009
Departments of Biochemistry University of Washington, Seattle, Washington. Int J Cancer. 2009 Sep 30.
DOI Direct Link
Antiangiogenic properties of prostate-specific antigen (PSA).
The prostate produces high levels of prostate-specific antigen (PSA, also...
3rd September, 2009
Department of Clinical Chemistry, Biomedicum, University of Helsinki and Scand J Clin Lab Invest. 2009;69(4):447-51.
DOI Direct Link
Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
BACKGROUND: More than a dozen single nucleotide polymorphisms (SNPs) have...
21st July, 2009
Center for Cancer Genomics, Wake Forest University School of Medicine, Prostate. 2009 Aug 1;69(11):1195-205.
DOI Direct Link
Quantitative expression of TMPRSS2 transcript in prostate tumor cells reflects TMPRSS2-ERG fusion status.
TMPRSS2-ERG fusion is the most common oncogenic rearrangement in prostate...
15th July, 2009
Urology Service, Department of Surgery, Walter Reed Army Medical Center, Prostate Cancer Prostatic Dis. 2009 Jul 14.
DOI Direct Link

View more research publications.

BioNews Results for KLK3

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Right on target
Drug Discovery News:  Nov 5 2009 10:59PM Matching: klk3

Clinical Trials:

Clinical Trials Logo
Mathematical Modeling Analysis of Serum Prostate Specific Antigen After Radiotherapy

Patents:

Patents logo
US Patent No.Title
6936436 Secreted and transmembrane polypeptides and nucleic acids encoding the same
7026448 Secreted and transmembrane polypeptides and nucleic acids encoding the same
7026449 Secreted and transmembrane polypeptides and nucleic acids encoding the same
7026455 Anti-pro 1343 antibodies
7029875 PRO1343 nucleic acids

View more patents.

KLK3 results (if any) from reagent suppliers

Google CSE Logo
KLK3 antibody, PSA, Total Antibody, Mouse Monoclonal Antibody
Buy quality mouse KLK3 antibody (interacts with n/a), anti-KLK3, PSA, Total antibody, mouse monoclonal antibody, PSA, Total Antibody, Mouse Monoclonal ...
http://www.genwaybio.com/product_info.php?products_id=240064...

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Human Kallikrein 3/PSA MAb (Clone 181827)
KLK3 is a member of the Kallikrein family of serine proteases. It is ... secondary reagents to detect human KLK3. The detection limit for rhKLK3 is ...
http://www.rndsystems.com/pdf/MAB13441.pdf...

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Antibodies to Proteins of Inflammation
K2889, Anti-Kallikrein 3 (KLK3, PSA) antibody produced in rabbit, (polyclonal), affinity isolated antibody, human ... KLK3(354) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Quantikine Human Kallikrein 3/PSA Immunoassay
Human tissue kallikrein 3 (KLK3), commonly known as prostate specific antigen ( PSA), is a ... The Quantikine KLK3/PSA Immunoassay is a 4.5 hour solid phase ...
http://www.rndsystems.com/pdf/DKK300.pdf...

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PSA (A67-B/E3) Antibody sc-7316
... Protein Accession #, OMIMâ„¢ Number. Human, KLK3, 354, 19q13.33, NM_001030047, NM_001030048, NM_001030049, NM_001030050, NM_001648 · P07288 ...
http://www.scbt.com/datasheet-7316-psa-a67-b-e3-antibody.htm...

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New Tools: Human Tissue Kallikrein Products - R&D Systems
1 Oct 2004 ... KLK3 is synthesized in the ductal and acinar epithelium of the ... Secreted KLK3 is found in the seminal plasma in high concentrations. ...
http://www.rndsystems.com/cb_detail_objectname_FA04_NTHumanT...

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Anti-Kallikrein 3 Polyclonal Antibody
KLK 3 (also known as prostate specific antigen or PSA) is a marker for prostatic cancer and is involved in the pathogenesis and/or progression of prostate, ...
http://www.bioreagents.com/products/productDetails/productDe...

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