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KLK3


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Symbol:KLK3
Name(s):kallikrein-related peptidase 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:APS, KLK2A1, PSA, hK3
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17593395 role of kallikrein gene 2 and 3 variant SNPs in the etiology of prostate cancer among men of European ancestry
17894328 docking studies elucidated the molecular details of the early noncovalent Michaelis complex, the acyl-enzyme covalent complex, and the nature of conformational reorganization required for the long term stability of the covalent complex.
17387315 According to our results, serum PSA levels and prostate volume in Korean SCI patients are not different from those in uninjured men and are not affected by injury characteristics.
18264097 Genome-wide association study of gene-disease association. (HuGE Navigator)
18306354 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18336535 Observational study of gene-disease association. (HuGE Navigator)
18187150 The first crystal structure of human PSA in complex with monoclonal antibody (mAb) 8G8F5 that enhances its enzymatic activity, is presented.
11299734 Observational study of gene-disease association. (HuGE Navigator)
12111704 Observational study of gene-disease association. (HuGE Navigator)
12168876 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-2-macroglobulin precursorprostate specific antigen isoform 1 preproprotein--Pubmed
HPRDalpha-2-macroglobulin precursorprostate specific antigen isoform 1 preproprotein--Pubmed
HPRDalpha-1-antichymotrypsin, precursorprostate specific antigen isoform 1 preproprotein--Pubmed
HPRDserpin peptidase inhibitor, clade A, member 3 precursorprostate specific antigen isoform 1 preproprotein--Pubmed
HPRDKallikrein 3erythropoietin receptor precursor--Pubmed
HPRDKallikrein 3fibronectin 1 isoform 3 preproprotein--Pubmed
HPRDKallikrein 3pregnancy-zone protein--Pubmed
BINDHomo sapiens prostate cancer antigen gene, promoter regionandrogen receptor isoform 1AR interacts with p-PSA.-Pubmed
BINDHomo sapiens prostate cancer antigen gene, promoter regionDNA directed RNA polymerase II polypeptide APol II interacts with p-PSA.-Pubmed
BINDHomo sapiens chromosome 19, reference assembly.-HTATIP (Tip60) interacts with the KLK3 (PSA) promoter.-Pubmed

Recent Publications on KLK3:

Pubmed Logo
Utility of kallikrein-related peptidases (KLKs) as cancer biomarkers.
BACKGROUND: The human kallikrein-related peptidase (KLK) family consists...
17th October, 2008
Department of Laboratory Medicine and Pathobiology, University of Toronto, Clin Chem. 2008 Oct;54(10):1600-7. Epub 2008 Aug 7.
DOI Direct Link
Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
PURPOSE: Fifteen independent genetic variants have been implicated in...
9th October, 2008
Center for Cancer Genomics, Wake Forest University School of Medicine, Clin Cancer Res. 2008 Sep 15;14(18):5819-24.
DOI Direct Link
Development of peptides specifically modulating the activity of KLK2 and KLK3.
The prostate produces several proteases, the most abundant ones being...
27th September, 2008
Department of Clinical Chemistry, Biomedicum Helsinki, University of Biol Chem. 2008 Jun;389(6):633-42.
DOI Direct Link
Gene expression changes associated with the anti-angiogenic activity of kallikrein-related peptidase 3 (KLK3) on human umbilical vein endothelial cells.
Kallikrein-related peptidase 3 (KLK3, also known as prostate-specific...
27th September, 2008
Department of Clinical Chemistry, Biomedicum Helsinki, University of Biol Chem. 2008 Jun;389(6):765-71.
DOI Direct Link
Immunofluorometric activity-based probe analysis of active KLK6 in biological fluids.
Immunoassay measurements of human kallikrein-related peptidases (KLKs)...
27th September, 2008
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Biol Chem. 2008 Jun;389(6):747-56.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Mathematical Modeling Analysis of Serum Prostate Specific Antigen After Radiotherapy
Prostate Cancer

Patents:

Patents logo
US Patent No.Title
5939264 Genes and genetic markers for improved reproductive traits in animals
6972186 Nucleic acid encoding pro 1410 polypeptides
7012131 Pro1410 polypeptides
7022497 Human kallikrein-like genes
7022498 Pro 1325 nucleic acids

View more patents.

KLK3 results (if any) from reagent suppliers

Google CSE Logo
K2889 Anti Kallikrein 3 KLK3 PSA antibody produced in rabbit ...
K2889 Anti-Kallikrein 3 (KLK3, PSA) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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KLK3 Antibody (C-term) Blocking Peptide
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in ...
http://www.abgent.com/products/catalog_no/BP6322b...

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KLK3 kallikrein-related peptidase 3
K2889, Anti-Kallikrein 3 (KLK3, PSA) antibody produced in rabbit affinity ... WH0000354M2, Monoclonal Anti-KLK3 antibody produced in mouse clone 1B1, ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

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Staphylococcus aureus Monoclonal Antibodies
KLK3 Polyclonal Antibody. ORDERING INFORMATION. Catalog No ... KLK3. is a specific marker for prostate. carcinoma that. has also been ...
http://www.qedbio.com/pdf/named/KLK3%2056236.pdf...

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WH0000354M2 Monoclonal Anti KLK3 antibody produced in mouse clone ...
WH0000354M2 Monoclonal Anti-KLK3 antibody produced in mouse clone 1B1, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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Human Kallikrein 3/PSA Affinity Purified Polyclonal Ab
This antibody has been selected for its ability to recognize human KLK3 in ... Immunohistochemistry - This antibody will detect KLK3 in cells and tissues. ...
http://www.rndsystems.com/pdf/af1344.pdf...

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Orbigen Inc. - Orbigen Inc.
KLH conjugated synthetic peptide comprised of amino acids 247 - 261 [ VHYRKWIKDTIVANP] of the human "kallikrein 3 (KLK3, Prostate Specific Antigen,
...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

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Human Kallikrein 3/PSA MAb (Clone 181823)
KLK3 is a member of the Kallikrein family of serine proteases. ... This antibody was selected for its ability to recognize human KLK3 in western blots and ...
http://www.rndsystems.com/pdf/MAB1344.pdf...

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QED Cancer Research Products Monoclonal Antibodies Antibody Tumor ...
56236, KLK3, This rabbit antibody recognizes aa 247-261 of human KLK3 ... /100 ug, KLK3. 56237, KLK4, This antibody recognizes aa 242-254 of human KLK4 ...
http://www.qedbio.com/cancer-research-products.htm...

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K
K2889, Anti-Kallikrein 3 (KLK3, PSA) antibody produced in rabbit ..... HPA000764 , Anti-KLK3 antibody produced in rabbit, affinity isolated antibody ...
http://www.sigmaaldrich.com/catalog/search/TablePage/1457466...

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