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FAS


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Symbol:FAS
Name(s):Fas (TNF receptor superfamily, member 6)
Type:protein-coding
Organism:Homo sapiens
Synonyms:ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17912028 This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets.
17970696 The increase in Fas and CTLA4 molecules in multiple sclerosis patients may lead to lymphocyte apoptosis, which suggests possible mechanisms underlying the therapeutic response to IFN-beta.
18324486 Our findings suggest that the changes in the expression of apoptotic proteins (Fas/FasL and caspase 8) in the thyroid gland of patients with autoimmune Graves Disease and Hashimoto's thyroiditis reflect their involvemetn in the pathogenesis.
18328427 Binding of CD95 Ligand to CD95 on glioblastoma cells recruit Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases.
18302883 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
18337305 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18361934 Observational study of gene-disease association. (HuGE Navigator)
18003704 TNF-alpha sensitizes primarily resistant endometrial stromal cells to Fas-mediated apoptosis.
18234961 This study identifies mitogen-activated protein kinase/ERK/Mcl-1 as an important survival signaling pathway in the resistance of melanoma cells to Fas-mediated apoptosis.
17993614 display reduced capacity for Fas-mediated death-inducing signaling complex formation

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDFas receptorBruton agammaglobulinemia tyrosine kinase--Pubmed
HPRDFas receptorfas ligand--Pubmed
HPRDFas receptordeath-associated protein 6--Pubmed
HPRDFas receptorprotein-tyrosine kinase fyn isoform a--Pubmed
HPRDFas receptorubiquitin-conjugating enzyme E2I--Pubmed
BIND-Fas-associated via death domainFas interacts with FADD.-Pubmed
BIND-Fas-associated via death domainAn unspecified isoform of Fas interacts with FADD.-Pubmed
BIND-nucleolar protein 3ARC interacts with an unspecified isoform of Fas.-Pubmed
HPRDFas receptorlymphocyte-specific protein tyrosine kinase--Pubmed
HPRDFas receptorFAS-associated factor 1--Pubmed

Recent Publications on FAS:

Pubmed Logo
A GC - magnetic sector MS method for identification and quantification of fatty acids in ewe milk by different acquisition modes.
A general method for qualitative and quantitative determination of fatty...
3rd November, 2009
Department of Chemistry, Biotechnology and Food Science, University of J Sep Sci. 2009 Oct 30.
DOI Direct Link
New insights into the mechanisms controlling neutrophil survival.
PURPOSE OF REVIEW: Neutrophil survival is regulated by a complex...
3rd November, 2009
Department of Immunology, IIHEMA, National Academy of Medicine, Buenos Curr Opin Hematol. 2009 Oct 29.
DOI Direct Link
Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells.
The growth of stem cells can be modulated by physical factors such as...
3rd November, 2009
Department of Biomedical Engineering, Pratt School of Engineering Duke Biomaterials. 2009 Oct 29.
DOI Direct Link
Clusterin and chemoresistance.
Resistance to anticancer agents is one of the primary impediments to...
3rd November, 2009
Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, Florida Adv Cancer Res. 2009;105:77-92.
DOI Direct Link
Dual Function of Cysteine Rich Domain (CRD) 1 of TNF Receptor Type 1: Conformational Stabilization of CRD2 and Control of Receptor Responsiveness.
The proinflammatory cytokine Tumor Necrosis Factor (TNF) exists as a...
3rd November, 2009
University of Stuttgart, Institute of Cell Biology and Immunology, Cell Signal. 2009 Oct 28.
DOI Direct Link

View more research publications.

Press Releases on FAS:

BioPortfolio Logo
Rochester Medical Reports Fourth Quarter and Annual Results and Announces Final Medicare Approval for Reimbursement for the FEMSOFT(R) Insert 5th November, 2009 Rochester Medical Corporation

STEWARTVILLE, Minn., Nov. 5 /PRNewswire-FirstCall/ -- Rochester Medical Corporation (Nasdaq: ROCM) today announced operating results for its fourth quarter and year ended September 30, 2009

Palomar Medical Reports Financial Results for Third Quarter 2009 29th October, 2009 Palomar Medical Technologies, Inc.

BURLINGTON, Mass., Oct. 29 /PRNewswire-FirstCall/ -- Palomar Medical Technologies, Inc. (Nasdaq: PMTI), a leading researcher and developer of light-based systems for cosmetic treatments, today

Marrow Donor Registration Drive Needs Diverse Cultures 1st October, 2009 Reval

BERKELEY, Calif., Oct. 1 /PRNewswire/ -- Nearly 70 percent of patients needing a marrow transplant do not have a matching donor in their family, leaving minorities particularly vulnerable

U.S. Supreme Court to Consider Fetal Alcohol Syndrome Death Penalty Case 28th September, 2009 National Organization on Fetal Alcohol Syndrome

*Immediate Media Interview Availability*

WASHINGTON, Sept. 28 /PRNewswire-USNewswire/ -- Fetal Alcohol Syndrome, the nation's leading preventable cause

VirtualScopics, Inc. Reports a Record Breaking Quarter 12th August, 2009 VirtualScopics, Inc.
-- Net loss for the quarter ended June 30, 2009 was ($413,123) compared to a net loss of ($851,110) for the second quarter of 2008. For the six months ended June 30, 2009, net

BioNews Results for FAS

: RSS Logo
BioPortfolio Logo
250 jobs to go as Glaxo shuts lab
Evening Herald:  Nov 12 2009 1:26PM Matching: fas
Pharmaceutical giant axes 250 jobs
Irish Independent:  Nov 11 2009 9:57PM Matching: fas
Pharmaceutical giant axes 250 jobs
Drogheda Independent:  Nov 11 2009 5:03PM Matching: fas
Healthcare giant to axe 250 jobs
Fingal Independent:  Nov 11 2009 2:04PM Matching: fas
11:41 Healthcare giant to axe 250 jobs
Kerryman:  Nov 11 2009 1:08PM Matching: fas
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Study Evaluating the Correlation Between C-11 Acetate Uptake and Retention as Measured by PET and FAS in Prostate Cancer

Patents:

Patents logo
US Patent No.Title
7603301 Verification and printing of a tax return in a network-based tax architecture
7605236 Antibodies that immunospecifically bind to B lymphocyte stimulator protein
7605238 Human CTLA-4 antibodies and their uses
7605245 PUFA polyketide synthase systems and uses thereof
7605903 Method for manufacturing color filter and method for manufacturing liquid crystal display device

View more patents.

FAS results (if any) from reagent suppliers

Google CSE Logo
FAS-L (CD95 Ligand) Antibody / FAS-L (CD95 Ligand) Antibodies
FAS-L (2.1) Antibody, sc-33716, mouse IgG1, extracellular (h), IP, IF, FCM, human ... FAS-L (CD95 Ligand) specific siRNA, sHRNA Plasmid and shRNA Lentiviral
...
http://www.scbt.com/table-fas-l_(cd95_ligand).html...

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Anti-Fas Ligand Monoclonal Antibody
Monoclonal Antibody against Fas Ligand for use in Immunofluorescence, Immunohistochemistry (Paraffin, Frozen), Immunoprecipitation, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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FAS (CD95) Antibody / FAS (CD95) Antibodies
FAS (DX-3) Antibody, sc-52525, mouse IgG1, N/A, IP, IF, FCM, human ... FAS (CD95 ) specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene ...
http://www.scbt.com/table-fas_cd95.html...

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Pacific Blue Anti-human CD95 Fas Antibody Anti-CD95 - BioLegend
Pacific Blue Anti-human CD95 Fas Antibody Anti-CD95 - CD95 is a 45 kD single chain type I glycoprotein also known as Fas, APO-1, and TNFRSF6.
http://www.biolegend.com/pacific-blue-anti-human-cd95-fas-an...

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FAS-L (NOK-1) Antibody sc-19681
See how others have used FAS-L (NOK-1): sc-19681 antibody and or FAS-L (NOK-1) ... Indirect FCM analysis of L5178Y-human FAS-L stable transfectant cell line
...
http://www.scbt.com/datasheet-19681-fas-l-nok-1-antibody.htm...

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LEAF Purified Anti-human Fas CD95 Antibody ...
LEAF Purified Anti-human Fas CD95 Antibody Anti-Fas - CD95 is a 45 kD single chain type I glycoprotein also known as Fas, APO-1, and TNFRSF6.
http://www.biolegend.com/leaf-purified-anti-human-fas-cd95%3...

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FAS (IPO-4) Antibody sc-52397
FAS shRNA (h) Lentiviral Particles, sc-29311-V, 200 µl ... Indirect FCM analysis of HuT 78 cells stained with FAS (IPO-4), followed by PE-conjugated goat ...
http://www.scbt.com/datasheet-52397-fas-ipo-4-antibody.html...

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