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IKBKB
| Symbol: | IKBKB | | Name(s): | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FLJ40509, IKK-beta, IKK2, IKKB, MGC131801, NFKBIKB | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18037881 |
MUC1 is important for physiological activation of IKKbeta and that overexpression of MUC1, as found in human cancers, confers sustained induction of the IKKbeta-NF-kappaB p65 pathway. |
| 18163512 |
IKKalpha and IKKbeta exert differential roles in ECM remodeling and endochondral ossification, which are events characteristic of hypertrophic chondrocytes in osteoarthritis |
| 17419715 |
There is an essential role of virus-induced IKK/NF-kappaB activity to trigger both viral IE gene expression and productive replication in quiescent cells. |
| 17997719 |
Pellino isoforms may be the E3 ubiquitin ligases that mediate the IL-1-stimulated formation of K63-pUb-IRAK1 in cells, which may contribute to activation of IKKbeta and transcription factor NF-kappaB, as well as signalling pathways dependent on IRAK1/4 |
| 17962807 |
the ability of NF-kappaB to regulate the G1-phase expression of key proto-oncogenes is subject to regulation by the integrated activity of IkappaB kinase (IKK)alpha, IKKbeta, Akt and Chk1 |
| 17947699 |
IKK2 is also involved in the IFN-gamma-stimulated release of the CXCR3 ligands through a novel mechanism that is independent NF-kappaB |
| 17939994 |
These data support a function for IKK2 as an antagonist of Aurora A signaling during mitosis. |
| 17684021 |
FAF1 robustly suppresses NF-kappaB activation through the inhibition of IKK activation in combination with previously reported cytoplasmic retention of NF-kappaB p65 |
| 17693255 |
Expression of activated IKK beta is associated with tuberous sclerosis complex 1 protein phosphorylation and vascular endothelial growth factor production in multiple tumor types. |
| 12637324 |
identified the alpha-chain of the GMCSF receptor as interaction partner of IkappaB kinase beta; direct interaction of IKKbeta and GMRalpha in cells was verified. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| BIND | Homo sapiens chromosome 11, reference assembly. | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | The cIAP-2 promoter interacts with IKK-beta. | - | Pubmed |
| HPRD | Caspase 8 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | - | - | Pubmed |
| HPRD | caspase 8 isoform A precursor | IKK beta | - | - | Pubmed |
| HPRD | IKK alpha | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | - | - | Pubmed |
| HPRD | conserved helix-loop-helix ubiquitous kinase | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | - | - | Pubmed |
| BIND | conserved helix-loop-helix ubiquitous kinase | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | IKK-alpha interacts with IKK-beta. | - | Pubmed |
| BIND | conserved helix-loop-helix ubiquitous kinase | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | IKKbeta interacts with IKKalpha. | - | Pubmed |
| HPRD | Beta catenin | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | - | - | Pubmed |
| HPRD | catenin, beta 1, 88kDa | IKK beta | - | - | Pubmed |
| HPRD | Fanconi anemia, complementation group A | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | - | - | Pubmed |
Recent Publications on IKBKB: |  |
Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K.
In this study, we investigated the metabolic phenotype of the NF-kappaB... | 29th October, 2009
| Pennington Biomedical Research Center, Louisiana State University System,
| J Biol Chem. 2009 Jul 3;284(27):18368-76. Epub 2009 May 11.
DOI Direct Link |
A lymphotoxin-driven pathway to hepatocellular carcinoma.
Hepatitis B and C viruses (HBV and HCV) cause chronic hepatitis and... | 16th October, 2009
| Department of Pathology, University Hospital Zurich, CH 8091 Zurich,
| Cancer Cell. 2009 Oct 6;16(4):295-308.
DOI Direct Link |
Angiogenic signaling triggered by cariogenic bacteria in pulp cells.
The inflammation observed in the dental pulp of teeth with deep caries... | 9th October, 2009
| Department of Cariology, Restorative Sciences, and Endodontics, University
| J Dent Res. 2009 Sep;88(9):835-40.
DOI Direct Link |
Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells.
Curcumin, a natural product isolated from the plant Curcuma longa, has a... | 24th September, 2009
| Laboratoire de Biologie Moleculaire et Cellulaire du Cancer, Hopital
| Ann N Y Acad Sci. 2009 Aug;1171:436-47.
DOI Direct Link |
Stat3 and the inflammation/acute phase response in involution and breast cancer.
The transcription factor Stat3 is essential for timely initiation of... | 17th September, 2009
| Department of Genetics, Molecular Biotechnology Center, University of
| J Mammary Gland Biol Neoplasia. 2009 Jun;14(2):121-9. Epub 2009 May 8.
DOI Direct Link |
→View more research publications. |
IKBKB results (if any) from reagent suppliers | 
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IKBKB Antibody
Specific antibody for the gene product of IKBKB, the protein Inhibitor of kappa light polypeptide gen enhancer in B-cells, kinase beta.
http://www.piercenet.com/Products/Browse.cfm?fldID=03E4C3FF-...
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IKK beta antibody, IKK beta [10AG2] Antibody, Mouse Monoclonal ...
Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, ... Part of a ternary complex consisting of TANK, IKBKB and IKBKG. ...
http://www.genwaybio.com/product_info.php?products_id=190733...
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p-IKK α/β (Ser 176) Antibody sc-21661
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, IKBKB, 3551, 8p11.21, NM_001556 ...
http://www.scbt.com/datasheet-21661-p-ikk-alpha-beta-ser-176...
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CKOZFN1027 CompoZr™ Knockout ZFN Kit human IKBKB (NM_001556)
CKOZFN1027 CompoZr Knockout ZFN Kit human IKBKB (NM_001556) CompoZr Knockout ZFNs create targeted double strand breaks at a gene specific target locus.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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Phospho-IKKb-Y199 Antibody
Inhibitor of nuclear factor kappa B kinase beta subunit; I-kappa-B-kinase beta; IkBKB; IKK-beta; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B ...
http://www.abgent.com/products/catalog_no/AP3127a_Phospho_IK...
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IKK alpha antibody, IKK alpha phospho S176, S180 Antibody, Rabbit ...
Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Directly interacts with IKK-gamma/NEMO and TRPC4AP ...
http://www.genwaybio.com/product_info.php?products_id=196653...
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IKK-beta Antibody Bethyl Laboratories
Alternative names for IKK-beta include I kappa B kinase beta, I-kappa-B kinase 2 , IKK2, NF-kappa B inhibitor kinase beta, NFKBIKB, and IKBKB. ...
http://www.bethyl.com/go/?product/A301-827A...
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