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FASLG


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Symbol:FASLG
Name(s):Fas ligand (TNF superfamily, member 6)
Type:protein-coding
Organism:Homo sapiens
Synonyms:APT1LG1, CD178, CD95L, FASL, TNFSF6
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18324486 Our findings suggest that the changes in the expression of apoptotic proteins (Fas/FasL and caspase 8) in the thyroid gland of patients with autoimmune Graves Disease and Hashimoto's thyroiditis reflect their involvemetn in the pathogenesis.
18302883 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
18361934 Observational study of gene-disease association. (HuGE Navigator)
17966039 regulation of FasL in SS patients with EEG may be due to transcriptional regulation, and the point mutation at - 259T/C in the FasL gene promoter region may lead to the down-regulation of FasL mRNA expression observed in SS patients with EEG.
18045865 CD95L-induced endosomal acidification, ceramide formation, and downstream events, such as p47(phox) phosphorylation, ROS formation, CD95 activation, and apoptosis.
18162459 In thyroid glands of patients with Graves disease the regulation of Fas/Fas ligand/Bcl-2 favors apoptosis of infiltrating lymphocytes.
18076022 The death receptor pathway was activated by the expression of Fas ligand (FasL) or addition of TNF-related apoptosis-inducing ligand (TRAIL) in the presence or absence of proteasome inhibitors.
14739535 Observational study of gene-disease association. (HuGE Navigator)
15042330 Observational study of gene-disease association. (HuGE Navigator)
15218339 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAmyloid beta A4 precursor protein binding, family B, member 1fas ligand--Pubmed
HPRDamyloid beta A4 precursor protein-binding, family B, member 1 isoform E9FAS ligand--Pubmed
HPRDFas receptorfas ligand--Pubmed
HPRDtumor necrosis factor receptor superfamily, member 6 isoform 1 precursorFAS ligand--Pubmed
HPRDFAS ligandPRPF40A protein--Pubmed
HPRDFAS ligandneutrophil cytosolic factor 1--Pubmed
HPRDFAS liganddeath-associated protein 6--Pubmed
HPRDFAS ligandfibronectin 1 isoform 3 preproprotein--Pubmed
HPRDFAS ligandprotein-tyrosine kinase fyn isoform a--Pubmed
HPRDFAS ligandSMT3 suppressor of mif two 3 homolog 1 isoform a precursor--Pubmed

Recent Publications on FASLG:

Pubmed Logo
FASLG polymorphism is associated with cancer risk.
Many studies have reported the association between the FASLG -844T/C...
29th October, 2009
Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University Eur J Cancer. 2009 Sep;45(14):2574-8. Epub 2009 May 4.
DOI Direct Link
Enrichment and analysis of secretory lysosomes from lymphocyte populations.
BACKGROUND: In specialized cells, such as mast cells, macrophages, T...
22nd October, 2009
Molecular Immunology, Institute of Immunology, University Hospital BMC Immunol. 2009 Jul 29;10:41.
DOI Direct Link
FAS and FAS ligand polymorphisms in the promoter regions and risk of gastric cancer in Southern China.
The FAS and FAS ligand (FASLG) system plays a key role in regulating...
10th October, 2009
Department of Molecular and Genetic Toxicology, Cancer Center, Nanjing Biochem Genet. 2009 Aug;47(7-8):559-68. Epub 2009 Jun 30.
DOI Direct Link
Target-dependent T-cell activation by coligation with a PSMA x CD3 diabody induces lysis of prostate cancer cells.
Recently, we have described a bispecific PSMA x CD3 diabody with one...
6th October, 2009
Department of Urology, Experimental Urology, University of Freiburg, J Immunother. 2009 Jul-Aug;32(6):565-73.
DOI Direct Link
Role of reactive oxygen species in proapoptotic ability of oncogenic H-Ras to increase human bladder cancer cell susceptibility to histone deacetylase inhibitor for caspase induction.
PURPOSE: Reveal mechanisms for the novel proapoptotic ability of oncogenic...
30th September, 2009
Anticancer Molecular Oncology Laboratory, College of Veterinary Medicine, J Cancer Res Clin Oncol. 2009 Nov;135(11):1601-13. Epub 2009 Jun 9.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
A Phase I Dose Finding Study of APO010 in Patients With Solid Tumors

Patents:

Patents logo
US Patent No.Title
7572640 Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
7550300 Prediction of bare metal stent restenosis

FASLG results (if any) from reagent suppliers

Google CSE Logo
FAS antibody, Fas (Intracell. Frag.) Antibody, Mouse Monoclonal ...
FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; CD95 antigen; Tumor necrosis factor receptor superfamily member 6, TNR6_HUMAN.
http://www.genwaybio.com/product_info.php?products_id=240277...

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Antibodies to Death Receptor Ligands
human ... FASLG(356), human, ARR, ELISA (i), FACS, ICC, IP, pricing. F1926, Monoclonal Anti-Fas Ligand antibody produced in mouse, Alf1.2 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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FAS-L (NOK-1) Antibody sc-19681
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, FASLG, 356, 1q24.3, NM_000639 ...
http://www.scbt.com/datasheet-19681-fas-l-nok-1-antibody.htm...

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Phospho-FAS-Y291 Antibody
Tumor necrosis factor receptor superfamily member 6 [Precursor]; FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; CD95 antigen; FAS; ...
http://www.abgent.com/products/catalog_no/AP3310a_Phospho_FA...

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F2051 Monoclonal Anti-Fas Ligand antibody produced in mouse ~1 mg ...
indirect ELISA: suitable. microarray: suitable. isotype, IgG1. Gene Information, human ... FASLG(356). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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CD95 antibody, CD95 [LT95] Antibody, Mouse Monoclonal Antibody
Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase- 8 to the activated receptor. The resulting death-inducing signaling complex ...
http://www.genwaybio.com/product_info.php?products_id=192193...

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Tumor Necrosis Factor (TNF)
FASLG (CD95L), TNFRSF1A (CD120a), TNFRSF10B (DR5), TNFRSF11B · LTA · TNFRSF1B ( CD120b), TNFSF10 (TRAIL). Transcription Factors. Gene Symbol ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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