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ILK
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17468516 |
PI3K/ILK/Akt/NF-kappaB axis is a promising target for therapeutic intervention in renal cell carcinoma. |
| 18214046 |
ILK expression does not appear to have a role in predicting outcome in patients with resected Hepatocellular cancer |
| 18037995 |
tPA induces LRP-1 tyrosine phosphorylation, which in turn facilitates the LRP-1-mediated recruitment of beta1 integrin and downstream ILK signaling, thereby leading to myofibroblast activation. |
| 17298394 |
findings show integrin-linked kinase activity is indispensable for streptococcal M1-induced paxillin recruitment and phosphorylation |
| 17951996 |
ILK mediated the effect of epithelial to mesenchymal transition in proximal tubular epithelial cells stimulated by CTGF |
| 17656471 |
PINCH-1, through its interaction with integrin-linked kinase, plays important role in regulating TGF-beta1-mediated epithelial-to-mesenchymal transition and could be potential future therapeutic target to prevent progression of renal disease. |
| 17553790 |
ILK may provide a linkage between kAE1 and the underlying actin cytoskeleton to stabilize kAE1 at the basolateral membrane, resulting in higher levels of cell surface expression |
| 17646580 |
A mutation (785C>T [Ala262Val]) is associated with loss of endothelial cells & cardiac dysfunction. It negatively affects cardiac mechanosensation. ILK maintains embryonic cardiomyocyte shape and ventricle morphology. |
| 12686550 |
role in protein kinase B/Akt activation. |
| 12925691 |
ILK is a critical mediator for tubular EMT and likely plays a crucial role in the pathogenesis of chronic renal fibrosis | →View more information from publications. |
Recent Publications on ILK: |  |
Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells.
Secretion of osteopontin (OPN) by cancer cells is a known mediator of... | 24th October, 2009
| Department of Oncology and Diagnostic Sciences, Dental School, University
| Exp Cell Res. 2009 Oct 20.
DOI Direct Link |
Integrin-linked kinase is an adaptor with essential functions during mouse development.
The development of multicellular organisms requires integrin-mediated... | 16th October, 2009
| Department of Molecular Medicine, Max Planck Institute of Biochemistry,
| Nature. 2009 Oct 15;461(7266):1002-6.
DOI Direct Link |
Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction.
Vascular smooth muscle cells (VSMCs) form contractile layers around larger... | 15th October, 2009
| Vascular Development Laboratory, UK London Research Institute, London WC2A
| Genes Dev. 2009 Oct 1;23(19):2278-83.
DOI Direct Link |
Fibronectin-integrin mediated signaling in human cervical cancer cells (SiHa).
Interaction between cell surface integrin receptors and extracellular... | 10th October, 2009
| Department of Receptor Biology and Tumor Metastasis, Chittaranjan National
| Mol Cell Biochem. 2009 Oct 9.
DOI Direct Link |
Prognostic significance of epithelial-mesenchymal transition in malignant pleural mesothelioma.
Background: Epithelial-to-mesenchymal transition (EMT) is a morphologic... | 29th September, 2009
| Division of Thoracic Surgery, University Hospital Zurich, Ramistrasse 100,
| Eur J Cardiothorac Surg. 2009 Sep 23.
DOI Direct Link |
→View more research publications. |
ILK results (if any) from reagent suppliers | 
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