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CXCL10


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Symbol:CXCL10
Name(s):chemokine (C-X-C motif) ligand 10
Type:protein-coding
Organism:Homo sapiens
Synonyms:C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18259970 Cytokine treatment (TNF-alpha, IL-1beta and IFN-gamma) increased IP-10 and IL-8 protein and mRNA levels. Fluticasone (0.1 nM to 1 microM) increased IP-10 but reduced IL-8 protein release without changing IP-10 mRNA levels assessed by real time RT-PCR.
18325387 Observational study of gene-disease association. (HuGE Navigator)
17963704 The serum IP-10 level was increased in AMI, and a higher level of serum IP-10 before PCI may be informative regarding infarct size.
18325387 Polymorphism G-210A in the promoter of CXCL10 gene could be a part of the genetic variation underlying the susceptibility of individuals to disease progression of chronic hepatitis B infection.
17957030 3 markers in chemokine (C-X-C motif) ligand 10 (CXCL10, 4q21, 11,101 C>T, P=.007; 1642 C
17250724 Observational study of gene-disease association. (HuGE Navigator)
17957030 Observational study of gene-disease association. (HuGE Navigator)
18085351 Serum IP-10 levels reflected ulcerative colitis disease activity, and the source of IP-10 was granulocytes and monocytes.
17763275 Pyelonephritis in pregnant women is associated with an increased maternal serum concentration of the chemokine CXCL10.
17943641 Patients with preeclampsia have significantly higher serum concentrations of chemokine (C-X-C motif) ligand 10(CXCL10/IP-10) than both normal pregnant women and mothers who have SGA neonates

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDversicansmall inducible cytokine B10 precursor--Pubmed
HPRDversicansmall inducible cytokine B10 precursor--Pubmed
BINDE1A binding protein p300Homo sapiens chromosome 4p300 interacts with promoter IP-10.-Pubmed
HPRDCXC chemokine receptor type 3small inducible cytokine B10 precursor--Pubmed
HPRDHomo sapiens CXC chemokine receptor transcript variant B mRNA, complete cds, alternatively splicedInterferon-gamma-inducible protein 10--Pubmed
HPRDIGF binding protein 7small inducible cytokine B10 precursor--Pubmed
HPRDinsulin-like growth factor binding protein 7Interferon-gamma-inducible protein 10--Pubmed
BINDinsulin-like growth factor binding protein 7small inducible cytokine B10 precursorMac25/AGM interacts with IP-10. This interaction was modeled on a demonstrated interaction between mouse Mac25/AGM and human IP-10.-Pubmed
BINDHomo sapiens chromosome 4interferon regulatory factor 3IRF3 interacts with promoter IP-10.-Pubmed
BINDHomo sapiens chromosome 4v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65p65 interacts with promoter IP-10.-Pubmed

Recent Publications on CXCL10:

Pubmed Logo
Human Rhinovirus-induced Epithelial Production of CXCL10 is Dependent upon IFN Regulatory Factor-1.
Human rhinovirus (HRV) infections are associated with exacerbations of...
3rd November, 2009
Department of Physiology & Pharmacology, University of Calgary, Airway Am J Respir Cell Mol Biol. 2009 Oct 30.
DOI Direct Link
Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells.
Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are found in diesel...
3rd November, 2009
Department of Air Pollution and Noise, Division of Environmental Medicine, Toxicol Appl Pharmacol. 2009 Oct 28.
DOI Direct Link
I-TAC is a dominant chemokine in controlling skin intragraft inflammation via recruiting CXCR3(+) cells into the graft.
Chemokines play a critical role in the acute transplant rejection. In...
31st October, 2009
Department of Immunology, Institute for Immunobiology, Shanghai Medical Cell Immunol. 2009 Sep 11.
DOI Direct Link
Age-associated changes in cardiac gene expression after preconditioning.
BACKGROUND: Cardiac protection afforded by ischemic preconditioning (IPC)...
28th October, 2009
Department of Anesthesiology, Stony Brook University School of Medicine, Anesthesiology. 2009 Nov;111(5):1052-64.
DOI Direct Link
Impairment of Interferon-{gamma} Signaling in Human Neutrophils Infected with Anaplasma phagocytophilum.
Anaplasma (A.) phagocytophilum, the causative agent of tick-borne human...
28th October, 2009
Institute of Medical Microbiology and Hygiene, University of Luebeck, Infect Immun. 2009 Oct 26.
DOI Direct Link

View more research publications.

BioNews Results for CXCL10

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Serum cytokine levels altered in euthymic bipolar disorder
MedWire News:  Nov 5 2009 4:45AM Matching: cxcl10

Clinical Trials:

Clinical Trials Logo
CXCL9, CXCL10, CXCL11, and CXCR3 in Dry Eye Syndrome

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7390884 Lymphoid chemokines in the diagnosis, monitoring and treatment of inflammatory disease
7375102 Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
7368253 Pre-symptomatic markers for diseases associated with transmissible spongiform encephalopathies
7332294 CXCL10-based diagnosis and treatment of respiratory illnesses

View more patents.

CXCL10 results (if any) from reagent suppliers

Google CSE Logo
CXCL10 Antibody Small inducible cytokine B10 precursor
CXCL10 antibody can be stored at 4C for short term (weeks) and -20C for long term.,
http://www.prosci-inc.com/shop/catalog1/CXCL10-Antibody-p-16...

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Cxcl10 antibody, IP-10 Antibody, Mouse IgG2a Monoclonal Antibody
Buy quality mouse igg2a Cxcl10 antibody (interacts with human), anti-Cxcl10, IP- 10 antibody, ... BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN IP-10; CXCL10; ...
http://www.genwaybio.com/product_info.php?products_id=175114...

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Mouse CXCL10/IP-10/CRG-2 Biotinylated Affinity Purified PAb
x-axis and read the corresponding mouse CXCL10 concentration. If samples have been diluted, the concentration read from the standard curve ...
http://www.rndsystems.com/pdf/BAF466.pdf...

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CXCL10/IP10, Mouse Anti-Human Chemokine (CXC motif) Ligand 10 ...
suggest a role for the C-X-C chemokines IL-8 and CXCL10/IP10 in the regulation of ... CXCL10/IP10 is associated with acute rejection processes estimated by ...
http://www.cellsciences.com/PDF/HM2030F.pdf...

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Cotton Rat CXCL10/IP-10/CRG-2 MAb (Clone 163426)
Anti-cotton rat IP-10/CXCL10 Antibody. FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS. ... chemokine superfamily and has been designated CXCL10. Formulation
...
http://www.rndsystems.com/pdf/mab1117.pdf...

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CXCL10/IP10, Mouse Anti-Human Chemokine (CXC motif) Ligand 10 ...
The monoclonal antibody 6D4 reacts specifically with Human CXCL10/IP10. ... suggest a role for the CXC chemokines IL-8 and CXCL10/IP10 in the regulation of
...
http://www.cellsciences.com/PDF/HM2030.pdf...

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Quantikine Human CXCL10/IP-10 ELISA
Human CXCL10/IP-10 Immunoassay. Catalog Number DIP100. SIP100. PDIP100 ... IP-10 (interferon-gamma inducible protein 10 kDa), also known as CXCL10, ...
http://www.rndsystems.com/pdf/dip100.pdf...

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