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INS


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Gene DB Home
Symbol:INS
Name(s):insulin
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18211635 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
18292987 Observational study of gene-disease association. (HuGE Navigator)
18310307 Observational study of gene-disease association. (HuGE Navigator)
17586504 Raloxifene has no adverse effect on insulin sensitivity or glucose tolerance, and it does not affect beta-cell function. After glucose load, raloxifene decreases hepatic insulin extraction and thus conserves insulin.
17901401 Human islet-derived precursor cells, which do not express the insulin gene, nonetheless uniquely exhibit epigenetic marks that could poise them for activation of insulin expression.
18083784 These results suggest the mechanisms underlying chronic insulin resistance in gestational diabetes may be driven by increased inflammation in skeletal muscle.
18220656 Extensive review of hyperglycemia-induced renal alterations
15834700 Observational study of gene-disease association. (HuGE Navigator)
15880482 Observational study of gene-disease association. (HuGE Navigator)
15949705 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDmajor histocompatibility complex, class II, DQ alpha 2proinsulin precursor--Pubmed
HPRDmajor histocompatibility complex, class II, DQ beta 1 precursorproinsulin precursor--Pubmed
HPRDinsulin-like growth factor 1 receptor precursorproinsulin precursor--Pubmed
BINDinsulin-like growth factor 1 receptor precursorproinsulin precursorInsulin interacts with IGF-IR. This interaction was modeled on a demonstrated interaction between Insulin from an unspecified species and human IGF-IR.-Pubmed
HPRDinsulin-like growth factor binding protein 7Insulin--Pubmed
HPRDInsulinlow density lipoprotein-related protein 2--Pubmed
HPRDInsulinthioredoxin-like 5--Pubmed
HPRDproinsulin precursorinsulin receptor--Pubmed
HPRDproinsulin precursornephroblastoma overexpressed precursor--Pubmed
HPRDproinsulin precursorsynaptotagmin-like 4--Pubmed

Recent Publications on INS:

Pubmed Logo
Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells.
Pancreatic beta-cells are responsible for insulin secretion that regulates...
3rd November, 2009
Biomedical Proteomics Research Group, Structural Biology and Proteomics. 2009 Oct 30.
DOI Direct Link
Apelin Inhibits Insulin Secretion in Pancreatic beta-Cells by Activation of PI3-Kinase-Phosphodiesterase 3B.
Aims. Apelin is secreted by adipocytes acting on APJ receptor and plays an...
3rd November, 2009
Department of Endocrinology and Metabolism, The Second Affiliated Hospital Endocr Res. 2009;34(4):142-54.
Electronic and Magnetic Study of Polycationic Mn(12) Single-Molecule Magnets with a Ground Spin State S = 11.
The preparation, magnetic characterization, and X-ray structures of two...
3rd November, 2009
Instituto de Ciencia Molecular, Universitat de Valencia, Poligono de la Inorg Chem. 2009 Oct 30.
DOI Direct Link
An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics.
AIMS/HYPOTHESIS: Minimal model analysis for insulin sensitivity has been...
31st October, 2009
Metabolic Unit, ISIB-CNR, Corso Stati Uniti, 4, 35127, Padova, Italy. Diabetologia. 2009 Oct 30.
DOI Direct Link
A Preliminary Candidate Genotype-Intermediate Phenotype Study of Satiation and Gastric Motor Function in Obesity.
Stomach motility contributes significantly to fullness sensation while...
31st October, 2009
Clinical Enteric Neuroscience Translational and Epidemiological Research Obesity (Silver Spring). 2009 Oct 29.
DOI Direct Link

View more research publications.

Press Releases on INS:

BioPortfolio Logo
National Investigational Trial for Emergency Stroke Care At CDH: One Illinois Hospital Tests New Device That May Reverse Brain Damage Up to 24 Hours After Stroke 12th October, 2009 Central DuPage Hospital

WINFIELD, Ill., Oct. 12 /PRNewswire-USNewswire/ -- Central DuPage Hospital (http://www.cdh.org) (CDH), in Winfield, Ill., is the only

Health Bill Could Benefit 6.6 Million Illegals 8th September, 2009 Center for Immigration Studies
    --  In 2007, there were an estimated 6.6 million illegal immigrants without
        health insurance who had incomes below 400 percent of poverty, which is
        the income ceiling for the
        
Lupin Expands Branded Play 30th June, 2009 Lupin Ltd.

Announces Acquisition of Worldwide Rights for its first NDA - AllerNaze(TM)

BSE: 500257 NSE: Lupin REUTERS: LUPN.BO BLOOMBERG: LPC IN

MUMBAI,

Insmed Completes Sale of Follow-On Biologics Platform to Merck & Co., Inc. for Gross Proceeds of $130 Million 31st March, 2009 Insmed Inc.

RICHMOND, Va., March 31 /PRNewswire-FirstCall/ -- Insmed Inc. (Nasdaq: INSM), a biopharmaceutical company, announced today that it has successfully closed the sale of all of the Company's

New Technology to Revolutionize the Way the Planet Does Business 16th March, 2009 Cybracero Systems

Innovative Company Makes it Possible for Employers to Hire Overseas Workers - Even for Domestic Manual Labor

LOS ANGELES, March 16 /PRNewswire/ -- Today's outsourcing

BioNews Results for INS

: RSS Logo
BioPortfolio Logo
Lilly Executive Announces Retirement
Inside INdiana Business:  Nov 13 2009 3:42PM Matching: ins
DARA BioSciences Presented Promising Preclinical Type 2 Diabetes Study Results at the Cambridge Healthtech Ins
GlobeNewswire via Yahoo!:  Nov 10 2009 2:23PM Matching: ins
Gene Therapy - Reports summarize gene therapy study results from University of Munich
NewsRX:  Nov 9 2009 6:36AM Matching: ins
Human Genetics - New human genetics research from University of Cambridge described
NewsRX:  Nov 8 2009 3:40AM Matching: ins
Israel stocks off 4th day; Discount, Teva in focus
MarketWatch:  Nov 1 2009 4:57PM Matching: ins
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Treatment Satisfaction of Insulin Glargine Plus Insulin Apidra Compared With NPH Insulin Plus Insulin Apidra in Recently Diagnosed Type 1 Diabetes Children and Adolescents

Patents:

Patents logo
US Patent No.Title
7607981 System and method for remote automated play of a gaming device
7610166 Geolocation system and method for determining mammal locomotion movement
7610207 Method for processing a digital image to satisfy a fulfillment request
7610233 System, method and article of manufacture for initiation of bidding in a virtual trade financial environment
7610261 System and method for acquisition, assimilation and storage of information

View more patents.

INS results (if any) from reagent suppliers

Google CSE Logo
Pdx1 Antibody #2437
Western blot analysis of extracts from INS-1 cells using Pdx1 Antibody. ... It plays an essential role in the commitment of endoderm to a pancreatic and ...
http://www.cellsignal.com/products/2437.html...

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monoclonal antibody template
Phosphorylation of Tyr 1162 and 1163 on INS R and Tyr 1135 and 1136 on IGF-I ... residues surrounding Y1162 and Y1163 of human INS R. This phosphopeptide is ...
http://www.rndsystems.com/pdf/AF2507.pdf...

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Antibodies to Human Plasma Proteins
C8159, Anti-C1-Esterase Inhibitor antibody produced in goat, (polyclonal) ... A3293, Anti-Human Albumin antibody produced in rabbit, (polyclonal) ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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Pdx1 Antibody
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM ... Western blot analysis of extracts from INS-1 cells using. Pdx1 Antibody. ...
http://www.cellsignal.com/pdf/2437.pdf...

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C Peptide antibody, C Peptide [1H8] Antibody, Mouse Monoclonal ...
Buy quality mouse C Peptide antibody (interacts with human - not yet tested in other species), anti-C Peptide, C Peptide [1H8] antibody, mouse monoclonal ...
http://www.genwaybio.com/product_info.php?products_id=192848...

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Antibodies to Other Protein/Peptide Hormones
C8198, Anti-Calcitonin Gene Related Peptide antibody produced in rabbit ... I6031, Anti-phospho-Insulin Receptor Substrate 1 (pSer616) antibody produced in
...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Polyclonal Anti-human Insulin R/CD220-Allophycocyanin
Insulin R/CD220: Supplied as 25 μg of antibody in 1 mL saline containing ... The insulin receptor (INS R) and insulin-like growth factor-1 receptor (IGF-1 ...
http://www.rndsystems.com/pdf/FAB1544A.pdf...

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