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O-fut1
| Symbol: | O-fut1 | | Name(s): | O-fucosyltransferase 1 | | Type: | protein-coding | | Organism: | Drosophila melanogaster | | Synonyms: | 4R6, AAF58290.1, CG12366, O-fut, OFUT1, l(2)SH2 2260, l(2)SH2260, ntc, nti | | Links: |
Pubmed,
Entrez Gene,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17329366 |
O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila. |
| 12909620 |
Down-regulation of OFUT1 by RNA interference in Notch-secreting cells inhibits both Delta-Notch and Serrate-Notch binding, demonstrating a requirement for O-linked fucose for efficient binding of Notch to its ligands |
| 15692013 |
OFUT1 has a distinct Notch chaperone activity; binds to Notch; required for the trafficking of wild-type Notch out of the endoplasmic reticulum; ability to facilitate folding of Notch |
| 12526814 |
that OFUT1 is a core component of the Notch pathway, which is required for the activation of Notch by its ligands, and whose regulation may contribute to the pattern of Notch activation during development |
O-fut1 results (if any) from reagent suppliers | 
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