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ITGA2B
| Symbol: | ITGA2B | | Name(s): | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CD41, CD41B, GP2B, GPIIb, GTA, HPA3 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18041653 |
oxidant systems external to platelets did not activate GP IIb/IIIa receptors while increased intra-platelet iron was associated with appearance of cytosolic oxidizing species and with GP IIb/IIIa receptor activation |
| 18211801 |
tyrosine phosphorylation of GIT1 by Src kinases may regulate cytoskeletal reorganization downstream of alpha(IIb)beta(3) by bringing the Rac guanine nucleotide exchange factor betaPIX to the vicinity of the integrin |
| 17630485 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11204574 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11260063 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11260064 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11341496 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 11367863 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11575217 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11698306 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Recent Publications on ITGA2B: |  |
Regulation of megakaryocytic differentiation of K562 cells by FosB, a member of the Fos family of AP-1 transcription factors.
The regulation of megakaryocytic differentiation is poorly understood.... | 26th September, 2009
| Division of Life and Pharmaceutical Sciences, Center for Cell Signaling &
| Cell Mol Life Sci. 2009 Jun;66(11-12):1962-73.
DOI Direct Link |
Genetic testing in the diagnostic evaluation of inherited platelet disorders.
Inherited disorders of platelets give rise to rare bleeding syndromes... | 28th August, 2009
| Centre de Reference des Pathologies Plaquettaires, Plateforme
| Semin Thromb Hemost. 2009 Mar;35(2):204-12. Epub 2009 Apr 30.
DOI Direct Link |
Molecular defects in ITGA2B and ITGB3 genes in patients with Glanzmann's thrombasthenia.
Summary Background: Glanzmann's thrombasthenia (GT) is an autosomal... | 21st August, 2009
| Department of Haematology, All India Institute of Medical Sciences, New
| J Thromb Haemost. 2009 Aug 19.
DOI Direct Link |
Mechanism of activation and functional role of protein kinase Ceta in human platelets.
The novel class of protein kinase C (nPKC) isoform eta is expressed in... | 1st July, 2009
| Department of Physiology, Temple University School of Medicine,
| J Biol Chem. 2009 May 15;284(20):13413-21. Epub 2009 Mar 13.
DOI Direct Link |
Alloantibodies against low-frequency human platelet antigens do not account for a significant proportion of cases of fetomaternal alloimmune thrombocytopenia: evidence from 1054 cases.
BACKGROUND: Maternal alloantibodies against the five common human platelet... | 9th June, 2009
| From the Department of Haematology, University of Cambridge, the Diabetes
| Transfusion. 2009 Jun 4.
DOI Direct Link |
→View more research publications. |
ITGA2B results (if any) from reagent suppliers | 
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ITGA2B antibody, CD41 gp11b/111a Antibody, Mouse Monoclonal Antibody
Buy quality mouse ITGA2B antibody (interacts with n/a), anti-ITGA2B, CD41 gp11b/ 111a antibody, mouse monoclonal antibody, CD41 gp11b/111a Antibody, ...
http://www.genwaybio.com/product_info.php?products_id=241112...
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Monoclonal Anti-mouse Integrin α2b/CD41-Phycoerythrin
Integrin α2b, (ITGA2b) also known as CD41 and GPIIb, is a transmembrane glycoprotein ... ITGA2b is required for platelet aggregation, and defects lead
to ...
http://www.rndsystems.com/pdf/FAB41181P.pdf...
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Integrin αIIb (C-20) Antibody sc-6602
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ITGA2B, 3674, 17q21.31, NM_000419 ...
http://www.scbt.com/datasheet-6602-integrin-alphaiib-c-20-an...
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CD41 antibody, CD41 Antibody, Mouse Monoclonal Antibody
Disease: Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM: 273800]; also known as thrombasthenia of Glanzmann and Naegeli. ...
http://www.genwaybio.com/product_info.php?products_id=310679...
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Integrin αIIb (MWReg30) Antibody sc-19963
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Itga2b, 16399, 11 E1, Q9QUM0 ...
http://www.scbt.com/datasheet-19963-integrin-alphaiib-mwreg3...
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CYR61 protein, Protein CYR61 recombinant protein
In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5. ...
http://www.genwaybio.com/product_info.php?products_id=5022...
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Integrin αIIb (MWReg30) Antibody sc-19963
Spezies, Gen, Gen ID, Chromosomaler Locus, mRNA (Isoform) Accession #, Protein Accession #, OMIM™ Nummer. Maus, Itga2b, 16399, 11 E1, Q9QUM0 ...
http://www.scbt.com/de/datasheet-19963-integrin-alphaiib-mwr...
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