BioPortfolio - Khc - Kinesin heavy chain

Khc

Symbol:

Khc

Name(s):

Kinesin heavy chain

Type:

protein-coding

Organism:

Drosophila melanogaster

Synonyms:

CG7765, DK, DKH, DmKHC, Dmkin, KIF5A, KIN, kinesin, l(2)W12, l(2)k13219, l(2)k13314, l(2R)W12

Links:

Pubmed, Entrez Gene, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

11823639

data strongly support an inchworm mechanism for the processive, high-duty-ratio movement of kinesin dimers

12403717

Data show that kinesin heavy chain can function independently of the light chain in the oocyte, indicating that it associates with its cargoes by a novel mechanism.

15583137

Drosophila fragile X mental retardation protein associates with both kinesin heavy chain and dynein heavy chain, but not kinesin light chain

16077093

Data show that the plus-end-directed microtubule motor kinesin-1 is required for cytoplasmic streaming and is constitutively capable of driving fast streaming.

11914091

Pathway of ADP-stimulated ADP release and dissociation of tethered kinesin from microtubules. Implications for the extent of processivity

12225672

Kinesin may generate anterodorsal forces directly, despite the preponderance of minus ends at the anterior cortex. Alternatively, kinesin I may facilitate cytoplasmic dynein-based anterodorsal forces by repositioning dynein toward microtubule plus ends.

12614154

Substitution of Glu164 with alanine in the motor domain results in a dimeric kinesin (E164A) with a dramatic reduction in microtubule-activated steady-state ATPase that is stalled on the microtubule and cannot bind and hydrolyze ATP at the second head.

15257294

sensitivity of the 16-nm displacements to nucleotide and load raises the possibility that ADP release is a force-producing event of the kinesin cycle

14657506

the discovery that kinesin limps along the microtubule, taken together with its other nanomechanical properties, implies that it advances by some form of asymmetric hand-over-hand mechanism

15005614

Glutamate 164 of the kinesin heavy chain is shown to be critical for kinesin function, its contribution providing new insights about the motor-microtubule interface and the pathway of communication for processive motility.

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