Sunday November 22 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

ARAF


Suggest Content
Advertise Here
Gene DB Home
Symbol:ARAF
Name(s):v-raf murine sarcoma 3611 viral oncogene homolog
Type:protein-coding
Organism:Homo sapiens
Synonyms:A-RAF, ARAF1, PKS2, RAFA1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
14684750 A-Raf kinase is negatively regulated by trihydrophobin 1
11952167 In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf.
14688025 mutation analysis of the conserved regions in the ARAF gene in human colorectal adenocarcinoma
15736953 A-Raf residues are identified that bind to specific phosphoinositides, possibly as a mechanism to localize the enzyme to particular membrane microdomains rich in these phospholipids.
16980614 These data reveal that B-RAF is an important mediator of neuronal survival, migration, and dendrite formation and that A-RAF cannot fully compensate for these functions.
8621729 A-Raf interacts with MEK1 and activates MEK1 by phosphorylation.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDARAF1related RAS viral oncogene homolog--Pubmed
HPRDARAF1translocase of inner mitochondrial membrane 44--Pubmed
HPRDSerine/threonine protein kinase Araf1PRP6 pre-mRNA processing factor 6 homolog--Pubmed
HPRDv-raf murine sarcoma 3611 viral oncogene homologTIM44--Pubmed
HPRDv-raf murine sarcoma 3611 viral oncogene homologRas related protein--Pubmed
HPRDv-raf murine sarcoma 3611 viral oncogene homologPhosphatidylinositol 3 kinase regulatory subunit, alpha--Pubmed
BINDv-raf murine sarcoma 3611 viral oncogene homolog-A-Raf interacts with an unspecified isoform of FBNL.-Pubmed
BINDv-raf murine sarcoma 3611 viral oncogene homolog-A-Raf interacts with an unspecified isoform of TH1.-Pubmed
BINDv-raf murine sarcoma 3611 viral oncogene homolog-ARAF (A-Raf) interacts with an unspecified isoform of HRAS (Ha-Ras).-Pubmed
BINDv-raf murine sarcoma 3611 viral oncogene homolog-ARAF (A-Raf) interacts with an unspecified isoform of PKM2 (PyK).-Pubmed

Recent Publications on ARAF:

Pubmed Logo
Presence of 1-->3-linked 2-O-beta-d-xylopyranosyl-alpha-l-arabinofuranosyl side chains in cereal arabinoxylans.
The presence of a fairly uncommon side chain...
24th October, 2009
Department of Applied Chemistry and Microbiology, Faculty of Agriculture Carbohydr Res. 2009 Oct 2.
DOI Direct Link
Immunostimulatory properties of coffee mannans.
Coffee infusion mannans are acetylated polysaccharides containing single...
15th October, 2009
Departamento de Quimica, Universidade de Aveiro, 3810- 193 Aveiro, Mol Nutr Food Res. 2009 Aug;53(8):1036-43.
DOI Direct Link
AftD, a novel essential arabinofuranosyltransferase from mycobacteria.
Arabinogalactan (AG) and lipoarabinomannan (LAM) are the two major cell...
6th August, 2009
Department of Microbiology, Immunology and Pathology, Colorado State Glycobiology. 2009 Nov;19(11):1235-47. Epub 2009 Aug 4.
DOI Direct Link
The effect of pretreatment with renin-angiotensin-aldosterone system blockers on cardioversion success and acute recurrence of atrial fibrillation.
BACKGROUND: Renin-angiotensin-aldosterone system (RAS) may be activated...
3rd July, 2009
Department of Cardiology, Medical School, Suleyman Demirel University, Int J Clin Pract. 2009 Jul;63(7):1017-23.
DOI Direct Link
Structure analysis of an acidic polysaccharide isolated from green tea.
An acidic polysaccharide (ATPS-2) was isolated and purified from coarse...
17th June, 2009
Institute of Food Engineering, College of Life & Environment Science, Nat Prod Res. 2009;23(7):678-87.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Stage III or Stage IV Melanoma

Patents:

Patents logo
US Patent No.Title
5679347 Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods
6492398 Thiazoloindolinone compounds
6498176 3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors
6500807 Modified pectin and nucleic acid composition
6620818 Method for reducing the severity of side effects of chemotherapy and/or radiation therapy

View more patents.

ARAF results (if any) from reagent suppliers

Google CSE Logo
Antibodies to Other Apoptosis-related Proteins
A5732, Anti-ARAF (40-54) antibody produced in rabbit, (polyclonal) .... WH0000369M1, Monoclonal Anti-ARAF antibody produced in mouse, 6H6 (monoclonal)
...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

Thumbshot
A-Raf (C-20) Antibody sc-408
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, ARAF, 369, Xp11.23, NM_001654 ...
http://www.scbt.com/datasheet-408-a-raf-c-20-antibody.html...

Thumbshot
Raf1 antibody (ab28832) | Abcam
The Raf family of serine/threonine specific kinases is comprised of three members (aRaf, bRaf, and cRaf) that play a critical role in regulating cell
growth ...
http://www.abcam.com/Raf1-antibody-ab28832.html...

Thumbshot
MEK-2 antibody, MEK-2 (Phospho-Thr394) Antibody, Rabbit Polyclonal ...
MEK-2 (Ab-394) Antibody Blocking Peptide, Peptide. PRODUCT INTERACTIONS: MEK-2 ( Phospho-Thr394) interacts with ARAF, IgG (GenWay Catalog #: 18-785-210273). ...
http://www.genwaybio.com/product_info.php?products_id=210273...

Thumbshot
p-A-Raf (Ser 299) Antibody sc-109899
Spezies, Gen, Gen ID, Chromosomaler Locus, mRNA (Isoform) Accession #, Protein Accession #, OMIMâ„¢ Nummer. Human, ARAF, 369, Xp11.23, P10398 ...
http://www.scbt.com/de/datasheet-109899-p-a-raf-ser-299-anti...

Thumbshot
ABGENT
ARAF. ARAF. ARAF. HH498. TESK1. TESK2. RIPK1. RIPK3. RIPK3. ANKRD3. SgK288. MLK3 . MLK2. ZAK. MLK1. MLK4. JAK1 b. Tyk2. bJAKb. FerFes. Abl Arg ...
http://www.abgent.com/downloads/Brain_Kinome.pdf...

Thumbshot
Your target is our aim
ARAF. BRAF. RAF1 (cRAF). KSR (KSR1). KSR2. MAP3K12 (DLK). MAP3K13 (LZK). MAP3K9 (MLK1)). MAP3K11 (MLK3). KIAA1804 (MLK4). MAP3K10 (MLK2). ZAK. MAP3K7 (TAK1) ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf.Pa...

Thumbshot

Search Bioportfolio and other Life Science Sites for ARAF, or search for ARAF on BioPortfolio's antibody search engine.
This page has been viewed 218 times
Recent Search Terms used to find this page:
ANTI-ARAF | ARAF Kinase recombinant | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.