Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18056258 |
a structural change in the conformation of anti-GPIIIa49-66 antibody contributes to its binding to the beta3 integrin and subsequent antibody-induced platelet fragmentation and aggregate dissolution |
| 17912026 |
Truncated beta3 may act as an anti-integrin and play a crucial role in cell migration, which is an important process in tumor invasion and metastasis. |
| 18208809 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18214290 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18260892 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18343248 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17959856 |
Fourteen of the antibodies reacted with a 29-kDa GPIIIa fragment comprising only the GPIIIa hybrid and plextrin-semaphorin-integrin homology domains |
| 18162078 |
Real-time PCR showed that ETOH significantly altered the expression of genes involved in cell adhesion. There was an increase in the expression of alpha and beta Laminins 1, beta Integrins 3 and 5, Secreted phosphoprotein1 and Sarcoglycan epsilon. |
| 18062611 |
Report observed that alphav-beta3 integrins and Focal Adhesion Protein-Tyrosine Kinases co-localize and that fibrillin filament attachment sites to endothelial cells merge with these molecules. |
| 18041653 |
oxidant systems external to platelets did not activate GP IIb/IIIa receptors while increased intra-platelet iron was associated with appearance of cytosolic oxidizing species and with GP IIb/IIIa receptor activation |
| 18211801 |
tyrosine phosphorylation of GIT1 by Src kinases may regulate cytoskeletal reorganization downstream of alpha(IIb)beta(3) by bringing the Rac guanine nucleotide exchange factor betaPIX to the vicinity of the integrin |
| 12082590 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12082592 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 12362250 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12499711 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12514663 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12518110 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 12578602 |
Observational study of genetic testing. (HuGE Navigator) |
| 12714203 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12716314 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12720308 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 12738509 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 12791034 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 12818249 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12827240 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12871600 |
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) |
| 12899665 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12902444 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12932598 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12957761 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 13678940 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 14557872 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14614355 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14634961 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14669168 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14675395 |
Observational study of genetic testing. (HuGE Navigator) |
| 14691438 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14691579 |
Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 14746139 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 14963283 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14987913 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14992889 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15076187 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15147527 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15166939 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15166947 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15166949 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15178823 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15219201 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15227729 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15331787 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 15355503 |
Observational study of genetic testing. (HuGE Navigator) |
| 15355504 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15546585 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15564935 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15565371 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15575508 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15609125 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15627799 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15676177 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15705408 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12071877 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 12073410 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11028489 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11053714 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 11151063 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 11235724 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11257275 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11341749 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 11397354 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 11447076 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11454259 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11533523 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11545752 |
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11568114 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11704375 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11714857 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11812069 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17556058 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17559347 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17630485 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17728329 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17827388 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17907177 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17928472 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17954176 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18021403 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18035074 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18057877 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18067652 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18160561 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 18160589 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18191725 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15817799 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15834589 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15840736 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15847651 |
Observational study of genetic testing. (HuGE Navigator) |
| 15970922 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15978110 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15990752 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16091654 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16100725 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16133898 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16153930 |
Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16157382 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16158739 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16248996 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16307159 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16317580 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16322334 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16353042 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16380674 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16444441 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 16567932 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16573563 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16635210 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16675000 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16702043 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16721604 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16724005 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16831169 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16875034 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16905953 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17111197 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17127487 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17138951 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17160992 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17196570 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17203304 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17206538 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17220212 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17230042 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17264806 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17278970 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17290027 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17320454 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17334320 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17346829 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17357883 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17406648 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17432927 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 15730528 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17559347 |
Glycoprotein IIIa (GPIIIa, platelet antigen A1 and A2) polymorphisms that contribute to resistance or augmented response to aspirin are rare in the Chinese population. |
| 18064323 |
Novel ancestral mutation found in a cluster of Jordanian Glanzmann thrombasthenia patients disrupts a conserved Cys549-Cys558 bond which results in reduced production of constitutively active alpha IIb beta 3. |
| 18084301 |
uPAR is required to activate alphavbeta3 integrin in podocytes, promoting cell motility and activation of the small GTPases Cdc42 and Rac1 |
| 18045938 |
the studies demonstrate that Vbeta3 is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD). |
| 17957566 |
platelet glycoprotein IIb-IIIa number (evaluated as maximal binding of (125)I-labelled antibody CRC64) varied from 40.5 to 80.8 x 10(3) per platelet with no significant influence of platelet glycoprotein III a(GP IIIa) genotype. |
| 17855352 |
analysis of Src and C-terminal Src kinase interactions in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton |
| 17607710 |
Expression of the human ITGB3 subunit in mouse smooth muscle cells enhances IGF-I-stimulated signaling and cell proliferation. |
| 17482311 |
OPN plays a crucial role for tumor growth and angiogenesis of human lung cancer cells in vivo by interacting with alphavbeta3 integrin. |
| 17907177 |
Our findings show that A2/A2 homozygosity is associated with an increased risk of visual loss due to anterior ischemic optic neuritis in giant cell arteritis. |
| 16818691 |
PET Molecular imaging of alpha(v)beta3 expression with [18F]Galacto-RGD in humans correlates with alpha(v)beta3 expression as determined by immunohistochemistry. |
| 17621633 |
establishes alphavbeta3 integrin as one key component of the transendothelial migration process of tumor cells, and as a potential target for anti-metastatic therapy |
| 17337041 |
in patients with stable coronary artery disease, an increased platelet reactivity after exercise, is specifically associated with an increased expression of platelet GP IIb/IIIa receptor |
| 17714854 |
Structural rearrangements undergone by integrin alpha(IIb)beta(3) after platelet activation were tested. |
| 17763154 |
effects of EDTA on GPIIb-IIIa dissociation and loss of adhesive functions are largely but not completely reve |
| 17615290 |
separation of transmembrane domains is required for integrin outside-in signal transduction |
| 17034033 |
The transition from a locally invasive phenotype to a metastatic phenotype may be primed by the elevated expression of alpha(v)beta(3) receptors in prostate cancer cells. |
| 17550972 |
Results suggest that CTGF plays a crucial role in migratory/invasive processes in human breast cancer by a mechanism involving activation of the integrin-alphavbeta3-ERK1/2-S100A4 pathway. |
| 17369840 |
Prostate cancer cells expressing fully functional but not dysregulated alphavbeta3 integrin are able to control their own adherence and migration to bone matrix, functions that facilitate tumor growth and control bone lesion development. |
| 17644514 |
Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/IIIa) receptors cooperate in NF-kappaB activation of human neutrophils |
| 17665449 |
preliminary findings show that the HPA-6 A/B genotype is a risk factor for autoimmune thrombocytopenia in systemic lupus erythematosus |
| 17538005 |
LOX-1 is important for ADP-stimulated inside-out activation of platelet alpha(IIb)beta(3) and alpha(2)beta(1) integrins |
| 17635696 |
Regions of alpha(IIb) and beta(3) cytoplasmic tails, together with membrane segments of the subunits, contact each other to form a complex which restrains the integrin in a resting state. It is unclasping of this complex that induces integrin activation. |
| 17641225 |
c-Src controls functional association between integrin alphav-beta3 and VEGFR-2 via integrin beta3 phosphorylation. |
| 17642204 |
The PIA2 allele did not alter the beneficial effect of statins on blood coagulation. |
| 17483236 |
Endothelial cell integrin alphaV beta3 is involved in sickle cell red blood cell adhesion. |
| 17679464 |
The proapoptotic ITGB3 cytoplasmic domain is rarely mutated in common human cancers and may not play an important role in the development of the cancers. |
| 16469512 |
Inhibition of alphaIIbbeta3 activation by NAD(P)H oxidase inhibitors and superoxide scavengers was independent of NO/cGMP signaling demonstrating a direct role of platelet NAD(P)H oxidase-generated ROS for integrin alphaIIbbeta3 activation. |
| 17332246 |
the surface density of fibrinogen affects alpha II b beta 3-mediated platelet signaling, adhesion, and spreading |
| 17258347 |
Inhibition of integrin alphavbeta3 leads to abrogation of migration of HSC stimulated with PDGF-BB and to an antifibrogenic gene expression pattern. |
| 15663601 |
Mu-calpain is activated in human endometrial cells during hypoxia and that subsequent cleavage of the integrin beta3 cytoplasmic domain may give some adverse effects to the function of human endometrium |
| 15863506 |
TPO integrates G(i), but not G(q), stimulation, supports integrin alpha(IIb)beta(3) activation platelet aggregation independently of phospholipase C but requires PI3-kinase and Rap1B |
| 15921657 |
Gal3ST-2 is involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrin alphaV but not beta3 |
| 15978110 |
platelet membrane integrins alpha IIb(beta)3 (HPA-1b/Pl) and alpha2(beta)1 (alpha807TT) polymorphisms may have a role in premature myocardial infarction |
| 12818251 |
Low concentrations of agonists resulted in enhanced platelet aggregation in subjects with the GNB3 CC-genotype compared to carriers of a 825T-allele. |
| 12511588 |
Integrin alphaiibbeta3 plays a role in signal transduction that leads to a defect in leukocyte adhesion |
| 12719784 |
binding of thrombin to GPIbalpha induces fibrin binding to resting alphaIIbbeta3 leading to fibrin-dependent platelet aggregation and clot retraction, that can be selectively inhibited by alphaIIbbeta3 antagonists |
| 16877710 |
interactions between alphaIIbbeta3 & ligands echistatin & fibrinogen's gamma-module; studies differentiate priming ligands, which bind to resting receptor & perturb its conformation, from regulated ligands, where binding-site remodeling must first occur |
| 11583324 |
Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF. |
| 12209993 |
Role for beta3 integrins in human melanoma growth and survival. |
| 12297512 |
co-stimulation of G(12/13) and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets in a mechanism that involves intracellular calcium |
| 12399420 |
activation state of alphaVbeta3 integrin is an important regulator of the duration of insulin-like growth factor I receptor phosphorylation and this regulation is mediated through changes in the subcellular localization of SHP-2 |
| 15695828 |
Pyk2 is a phosphorylated beta(3) binding partner, providing a potential structural and signaling platform to achieve alpha(V)beta(3) -mediated remodeling of the actin cytoskele |
| 12871468 |
high prevalence of the HPA-1b allele of beta3 in Glanzmann thrombasthenia |
| 17357883 |
No association between GpIIIa polymorphism with either type 2 diabetes or ST elevation acute myocardial infarction. |
| 12152649 |
Two different beta3 cysteine substitutions alter alphaIIb beta3 maturation and result in Glanzmann thrombasthenia. |
| 12152651 |
Integrin-linked kinase transiently associates with and phosphorylates beta3, regulating platelet integrin alphaIIb beta3 in a PI3-kinase dependent manner |
| 15299032 |
secondary structure analysis of integrin alphaVbeta3 |
| 15701653 |
integrin alphaIIbbeta3 has a role in mechanotransduction for shear activation of platelets |
| 15701721 |
alphaIIb-mediated outside-in signaling resulting in TxA(2) production and granule secretion is negatively regulated by a sequence of residues in the membrane distal beta3 cytoplasmic domain sequence RKEFAKFEEER. |
| 14966135 |
CD47-alpha(v)beta(3) interactions that lead to integrin clustering are detergent resistant and do not require cholesterol or the transmembrane region of CD47 |
| 17264806 |
Individuals homozygous for the integrin beta3 Leu33Pro polymorphism have a two-fold risk of hip fracture, mainly confined to postmenopausal women. |
| 15634267 |
a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia |
| 17032655 |
platelet alphaIIbbeta3 is activated by an exogenous peptide corresponding to the transmembrane domain of alphaIIb |
| 17414216 |
Discussion of recent developments in elucidating the mechanism of integrin activation, with particular focus on the platelet integrin alphaIIbbeta3, is provided in this review |
| 15056669 |
analysis of the three-dimensional model of integrin alphaIIbbeta3 |
| 15886806 |
an apparently silent beta3 mutation results in aberrant splicing and reduced beta3 mRNA and may play a causative role in Type I Glanzmann thrombasthenia |
| 12370491 |
An autocrine loop of the integrin alpha(V)beta(3)/CD47 receptor complex and thrombospondin-1 is identified as the molecular coupling device between mechanical loading and apoptosis. |
| 15187087 |
results indicate a new interaction partner for the alpha(v)beta(3) integrin, the TGFbetaIIR, in which TGFbeta1-induced responses are potentiated in the presence alpha(v)beta(3) ligands |
| 16716076 |
while the C-terminal region of the alpha(IIb) tail minimally influences alpha(IIb)beta(3) activation, the C-terminal region of the beta(3) tail is critically involved |
| 16895913 |
Protein kinase C delta is positively regulated by platelet alpha IIb beta 3 outside-in signaling in platelet function. |
| 11858476 |
Review. Alpha(v)beta3 integrins are involved in vascular repair processes. The challenge is to develop a therapeutic agent that will prove effective in reducing restenosis in humans following percutaneous coronary intervention (PCI). |
| 11858493 |
GPIIb-IIIa complexes are not in an activated conformational state after dissociation of abciximab unless there is an additional source of activation. |
| 12008962 |
Site-directed mutagenesis of residues on the top surface of the integrin beta3 I-domain that contains a putative ligand binding site identified D158 and N215 as novel residues critical for ligand binding. |
| 12372469 |
in patients with endometriosis a significant negative correlation was observed between luminal expression of eNOS and alpha(v)beta(3) integrin and between glandular expression of eNOS and luminal expression of alpha(v)beta(3) integrin |
| 12736272 |
the extracellular Ig domain of IAP(CD47), when bound to thrombospondin, interacts with integrin alphaIIbbeta3 and can change alphaIIbbeta3 in a high affinity state without the requirement of intracellular signaling |
| 12200372 |
Disruption of the long-range GPIIIa Cys(5)-Cys(435) disulfide bond results in the production of constitutively active GPIIb-IIIa (alpha(IIb)beta(3)) integrin complexes. |
| 12637342 |
Review. A signal is initiated at the cytoplasmic tail to transform the extracellular domain of alphaIIbbeta3 into a functional receptor for fibrinogen or von Willebrand factor to support platelet aggregation & thrombus formation. |
| 15705408 |
association between early fetal loss and the presence of the PLA2 polymorphism of the ITGB3 gene |
| 16721604 |
Data showed that ITGB3 and SLC6A4 expression levels are correlated. |
| 12036875 |
A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia |
| 15699036 |
there is a phosphorylation-dependent association between beta(3) integrin and Vav1 which is essential for cell progression to a Rho-dominant phenotype during cell adhesion |
| 12660257 |
Alphavbeta3 integrin expression and pinopode formation in human endometrium are processes closely related to endometrial maturation; unlikely as targets for contraceptive approaches or fertility-promoting strategies |
| 14593208 |
results invoke a model whereby Src is primed for activation by direct interaction with an integrin beta tail, and integrin clustering stabilizes activated Src by inducing intermolecular autophosphorylation |
| 15509546 |
CEACAM1 and alpha(v)beta(3) integrin are functionally interconnected with respect to the invasive growth of melanomas |
| 16005200 |
integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases |
| 16859511 |
beta3 integrin alters TGF-beta signaling in mammary epithelial cells via Src-mediated TbetaR-II tyrosine phosphorylation, which significantly enhanced the ability of TGF-beta to induce epithelial to mesenchymal transition and invasion. |
| 17334320 |
All patients with ISSNHL should undergo a comprehensive hematologic investigation of inherited and acquired prothrombotic factors, including platelet and V Leiden mutations, to identify a subset of patients at high risk of recurrent HL. |
| 15045135 |
in the absence of GPIbalpha or following inhibition of thrombin binding to GPIbalpha, there is a reduction in the thrombin-induced calcium flux, beta3 cleavage and micro -calpain activation. |
| 11875117 |
beta3-Integrin expression was directly up-regulated by HOXA10 in the endometrium |
| 12393510 |
a 17-amino acid sequence is identified as a common epitope for antibodies associated with quinine-induced immune thrombocytopenia |
| 12609844 |
data suggest that despite partial disruption of calf-1 or calf-2 domain by mutation in Glanzmann thrombasthenia, glycoprotein IIb/IIIa complex is formed but its transport from the endoplasmic reticulum is impaired |
| 17468108 |
integrins alphaLbeta2 and alphaIIbbeta3 are activated by mutation of a conserved asparagine in the I-like domain |
| 12874388 |
integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells |
| 15178823 |
GpIIIa gene polymorphism as a risk factor for stroke caused by large vessel disease in males. |
| 12161360 |
Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma. |
| 15456946 |
Data suggest that modulating the expression of integrin subunits beta3/5 in human neurons may enhance adenoviral infectivity via the coxsackie-adenovirus receptor. |
| 16150802 |
alphavbeta3 integrin is transiently up-regulated (and activated) in graft arteriopathy |
| 12586134 |
possible association between the GPIIb/IIIa PIA1/A2 polymorphism and the occurrence of cryptogenic stroke in young patients |
| 16317099 |
beta3 knockout mice transfused with wild-type platelets generated specific anti-beta3 antibodies which were able to induce thrombocytopenia in wild-type mice. |
| 16359515 |
three beta-propeller mutations do not affect the production of pro-alpha(IIb), its ability to complex with beta3, or its stability, but do cause variable defects in transport of pro-alpha(IIb)beta3 complexes from the endoplasmic reticulum to the Golgi |
| 12372811 |
thrombin interacts with alphavbeta3 as demonstrated by direct binding of alphavbeta3 protein to immobilized thrombin. |
| 14521607 |
the E749ATSTFTN756 region of the beta3-tail stabilizes the binding of soluble and surface-bound ligand to integrin alphaIIbbeta3 via a mechanism that involves the phosphorylation of FAK |
| 15134555 |
This review discusses the major role played by glycoprotein IIb/IIIa (GPIIb/IIIa) in the regulation of platelet adhesion and aggregation during hemostasis. |
| 11812775 |
Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3 |
| 16105876 |
Data show that alpha(v)beta3/Tat interaction triggers the activation of NF-kappaB in endothelial cells in a focal adhesion kinase-, RhoA- and pp60src-dependent manner, and this activation is required for motogenic activity of Tat in endothelial cells. |
| 16322781 |
analysis of platelet integrin alphaIIbbeta3 structure and function (review) |
| 16634766 |
the Pro33 isoform of purified integrin alphaIIbbeta3 has increased fibrinogen and prothrombin binding |
| 16935858 |
Tyrosine phosphorylation of beta3 promotes integrin outside-in signaling, by which the timing and location of calpain cleavage of integrins are dynamically regulated. |
| 17074516 |
Cell surface expression of alphavbeta5 resulted in an attenuation of alphavbeta3-mediated migration on vitronectin |
| 17175151 |
type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells |
| 17278970 |
data suggest that the Pl(A2) polymorphism is a genetic determinant of ischemic stroke in a selected high-risk hypertensive population |
| 17439948 |
activation of ITGB3 transcription required a HoxA10 domain that was not identical to the "hexapeptide" that mediates interaction of Hox and Pbx proteins |
| 17556058 |
Significant associations between single nucleotide polymorphisms in ITGB3 and asthma, wheezing, and IgE levels suggest an early role for this gene in the development of asthma and allergy. |
| 11891802 |
location was observed on or near the cell surface suggesting it might participate in surface membrane transport of iron |
| 12553378 |
has a role in the early phase of liver metastasis |
| 12911597 |
Glycoprotein IIb/IIIa has a role in platelet-activating factor-induced platelet activation with protein kinase C activity |
| 12690916 |
role of polymorphisms in cardiovascular thrombotic disease [review] |
| 12691260 |
Data suggest that this alphavbeta3 binding to alpha5-laminins is involved in the regulation of cellular responses to growth factors known to be involved in epithelial and endothelial development. |
| 12730600 |
results suggest that homomeric associations involving transmembrane domains provide a driving force for integrin activation; results also suggest a structural basis for the coincidence of integrin activation and clustering |
| 12941045 |
the 749EATSTFT756N and 755TNITYRG762T regions of beta3 contribute to the regulation of alphaIIbbeta3 anchorage to the cytoskeleton and platelet spreading to an adhesive surface |
| 14524530 |
integrin alpha(v)beta3 has an important role in bone metabolism and angiogenesis, and in controlling growth of metastatic prostate cancer cells in the bone |
| 14525764 |
proteins regulated by CBFA2 are required for inside-out signal transduction-dependent activation of GPIIb-IIIa |
| 15166241 |
alpha IIb beta 3 signaling in platelets is regulated by SHIP1 and Lyn kinase |
| 16113799 |
ITGbeta3 subunit cytoplasmic domains require membrane anchorage and the NPXY motif to recruit to adhesion complexes |
| 16380674 |
Our results did not show the causative relationship between the existence of platelets GP IIIa mutations and venous system thrombosis in the women in labor. |
| 16724005 |
we show that a coding variant of ITGB3 is associated with autism susceptibility in a large multiplex sample (P = 0.00082), and that this variation has different effects in males and females (P = 0.0018). |
| 16822941 |
Results suggest that shear stress directly modulates alpha(IIb)beta(3) function and that the shear-induced signaling contributes to regulation of platelet aggregation by directing the release of constraining cytoskeletal elements from the beta(3)-tail. |
| 16879215 |
analysis of platelet integrin alphaIIbbeta3 mutations that may play a role in Glanzmann thrombasthenia |
| 17146626 |
Transduction of beta3 integrin subunit cDNA confers on human keratinocytes the ability to adhere to denatured collagen (gelatin). |
| 17220212 |
The ITGB3_Leu33Pro polymorphism may potentially increase the risk of ovarian cancer in Polish women with an inherited BRCA1 mutation. |
| 12218055 |
regulation of integrin function by CD47 ligands: differential effects on integrin-mediated adhesion |
| 12460991 |
role of Pro33 polymorphism in enhanced activation of mitogen-activated protein kinase and myosin light chain kinase |
| 15795319 |
We conclude that the ectodomain of alphaVbeta3 manifests a bent conformation that is capable of stably binding a physiological ligand in solution. |
| 16102042 |
GPVI and integrin alphaIIb beta3 have roles in signaling during platelet adhesion and platelet aggregation [review] |
| 12799374 |
identification of binding site in gamma C-domain of fibrinogen |
| 15227729 |
For HPA-1 gene polymorphism, only the HPA-1a/a (PlA1/A1) genotype was observed in Korean population cardiac patients |
| 15976180 |
reactive oxygen species produced in platelets significantly affected alphaIIbbeta3 integrin activation |
| 16317580 |
ITGB3 gene polymorphisms is associated with breast cancer |
| 11962738 |
Immunohistochemical analysis of human tumor sections from several organs showed a heterogeneus distribution of CD61 in metastatic cases from colon and breast carcinoma. However, no staining was found in metastasis from melanoma. |
| 12168086 |
integrin alphaVbeta3 expression is reduced when ROR alpha is activated in prostate cancer cells |
| 15638730 |
The Integrin beta3 receptor is expressed on almost all cells originating from the mesenchyme and seem to mediate several biological processes, including adhesion of osteoblasts to the bone matrix. |
| 12237112 |
phosphoinositide 3-kinase C2alpha was found to be differentially regulated by alpha(v)beta(3) engagement |
| 11776310 |
A naturally occurring point mutation in the beta3 integrin MIDAS-like domain affects differently alphavbeta3 and alphaIIIbbeta3 receptor function. |
| 15226180 |
CD151 is essential for normal platelet function and that disruption of CD151 induced a moderate outside-in integrin alpha(IIb)beta(3) signaling defect |
| 15834425 |
Epidermal growth factor receptor and alphavbeta3 work together as coreceptors for Human cytomegalovirus entry and signaling. |
| 15917997 |
PI3-K and calcium oscillation are synergistically operated and form a positive-feedback regulation in integrin alpha(IIb)beta3-mediated outside-in signaling |
| 16115959 |
Data show that protein-tyrosine phosphatase (PTP)-1B is an essential positive regulator of the initiation of outside-in alphaIIbbeta3 integrin signaling in platelets. |
| 12694355 |
This study revealed detailed topography of integrins in malignant tumours derived from intercalated acinar segment of salivary gland which might be useful their diagnosis , especially of fine-needle aspiration products or from incisional biopsy. |
| 16213489 |
Cells overexpressing beta3 integrin can bind human ADAM12 via beta3 integrin. |
| 16322334 |
Integrin beta(3) Leu33Pro homozygotes have an increased risk of ovarian cancer. |
| 16407244 |
cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption |
| 16636497 |
P-selectin expression, but not activated GPIIb/IIIa, is enhanced in ADP-activated platelets in the inflammatory stage of Takayasu's arteritis. SELP may play a significant role in the inflammatory and thrombotic responses associated with intractable TA |
| 16676352 |
Results describe the multifunctional behavior of integrins, including integrin beta 3, based on their modification potential at hydroxyl groups of amino acids as a source of interplay. |
| 16969099 |
N-cadherin and beta3 integrin expression correlates with progression to advanced-stage melanoma. |
| 17272505 |
T cells epitopes on Glycoprotein IIIa. |
| 12031826 |
Factor XIII mediates adhesion of platelets to endothelial cells through alpha(v)beta(3) and glycoprotein IIb/IIIa integrins. |
| 12426312 |
Ligand binding promotes the entropy-driven oligomerization of this protein |
| 12765524 |
Data provide the first evidence that alphavbeta3 integrin can generate apoptosis-stimulating signals. |
| 12807887 |
alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors |
| 12855229 |
analyzed the possible cooperation effect between the PlA2 allele (GPIIIa) and LL genotype (SLC6A4) in the development of myocardial infarction |
| 15076187 |
APOC3, LPL and GpIIIa genes were found to be associated with BP levels. The contributions of these genes, although modest, are consistent with the polygenic nature of blood pressure levels. |
| 12826159 |
relationships between the expression levels of CD61, CD63, and PAC-1 on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation |
| 15331787 |
The HPA-1b (PlA2) allele significantly protected against subarachnoid hemorrhage. |
| 15344881 |
analysis of F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa in human platelets |
| 15044441 |
alphavbeta3 integrin has a role in regulating proliferation and apoptosis of hepatic stellate cells |
| 15840736 |
Results support the hypothesis that carriers of the GP IIIa PlA2 allele might have an increased risk for acute coronary syndrome in Hungarian population. |
| 15842360 |
SHPS-1 negatively regulates platelet function via CD47, especially alpha(IIb)beta(3)-mediated outside-in signaling |
| 16133898 |
Glycoprotein IIIa allele has been found in many studies to associate with risk of thrombosis. |
| 16195248 |
The 177-184 sequence of beta3 is necessary for vitronectin binding to alphaVbeta3. |
| 16504741 |
T cells from kidney allograft recipients can express significant amounts of alpha-beta 3 integrin (CD41/CD61. |
| 16513293 |
These results establish the beta3 gene as a direct target of NFATc1 in RANKL-dependent osteoclast formation. |
| 17203213 |
beta3 integrin in MDA-MB-231 breast cancer cells may lead to increased MMP-2 expression and activity and might contribute to the enhanced invasive potential observed |
| 14690453 |
Cysteine residues in the epidermal growth factor domains of the beta3 subunit are important for the ligand binding activity of the integrin alphaIIbbeta3 complex. |
| 12902444 |
Individuals homozygous for the Leu33Pro polymorphism of the beta3 integrin subunit have an increased cancer risk. |
| 14629479 |
The mutation at the position 29 107 of intron 10, G-->T, in the beta3 genomic DNA was found to induce an aberrant splicing and to be responsible for Glanzmann's thrombasthenia in this patient |
| 15468167 |
beta3 integrins play important roles during transendothelial migration of PC3 cells while interacting with the matrix underneath the endothelium. These interactions are independent of the ability to cluster beta3 integrins into focal adhesions. |
| 15826939 |
dephosphorylation events play a role via serine/threonine phosphatases during the integrin outside-in signaling mechanism, and the Leu(33) --> Pro polymorphism regulates this process |
| 15998788 |
melanoma cells cross-present, in an alpha v beta3-dependent manner, an antigen derived from secreted matrix metalloproteinase-2 (MMP-2) to human leukocyte antigen A*0201-restricted T cells |
| 16035619 |
Highest expression of alphavbeta3 integrin is associated with metastatic potential of osteosarcoma cells by enhancing the ability of the cells to migrate specifically to the lung |
| 12639965 |
thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components |
| 16412752 |
The endometrial expression of beta3 integrin subunit is reduced in the presence of tubal phimosis or hydrosalpinx, during the window of implantation. |
| 12237321 |
promotion of integrin alpha Vbeta 3-dependent endothelial cell adhesion by PGE2 |
| 12682293 |
tumstatin binds to alpha v beta 3 integrin in a vitronectin/fibronectin/RGD cyclic peptide independent manner |
| 12771130 |
alphavbeta3 expression in LNCaP (beta3-LNCaP) prostate cancer cells causes increased cdc2 mRNA levels as evaluated by gene expression analysis, and increased cdc2 protein and kinase activity levels |
| 11897046 |
A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia prevents GPIIbIIIa from binding fibrinogen when platelets are activated. |
| 15834589 |
variation in ITGB3 in addition to Leu33Pro could contribute to susceptibility to cardiovacular disease and serotonin in a sex-specific manner |
| 11686325 |
Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity. |
| 12364323 |
role in mediating pro-angiogenic activity of CYR61 |
| 15565371 |
PlA1/A2 polymorphism of platelet glycoprotein IIIa (GPIIIa) has is not implicated in the pathogenesis of type 2 diabetes. |
| 12427871 |
Data show a novel mechanism by which ECM regulates membrane-type 1 matrix metalloproteinase (MT1-MMP) association with beta1 or alphavbeta3 integrins, thus modulating its internalization, activity, and function on human endothelial cells. |
| 14517343 |
increased expression of the alpha(v)beta(3) integrin during breast cancer progression can make tumor cells more responsive to malignancy-promoting ligands such as OPN and result in increased tumor cell aggressiveness. |
| 15590407 |
A novel 465T-->C (S123P) mutation in exon 3 interfered with the platelet aggregation in a manner similar to Glanzmann's thrombasthenia. |
| 15748237 |
Of the 22 Glanzmann thrombasthenia patients studied, mutations were detected in 12 individuals. Of these, 11 were novel mutations. |
| 14681220 |
activation of the beta subunit I-like domain of integrin beta3 is analogous to that of the alpha subunit I domain |
| 12210725 |
alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts |
| 12668663 |
Intercellular calcium communication is primarily mediated by a signaling mechanism operating between this protein, ITGA2B and the adenosine diphosphate purinergic receptor P2Y12. |
| 16051597 |
the engagement of alphaIIb beta3 by the C-terminal sequence of the fibrinogen gamma-chain initiates signals that suppress subsequent fibronectin assembly by spread platelets |
| 16400188 |
the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer |
| 17158881 |
identifies integrin alphaVbeta6 as a novel cellular receptor for fibrillin-1 with a K(d) of approximately 0.45 mum |
| 17446174 |
Necl-5 has a critical role in integrin alphavbeta3 clustering and focal complex formation |
| 12486108 |
integrin alpha5beta1-mediated control of the levels of integrin alphaVbeta3 is important for the distribution of focal contacts |
| 11940607 |
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton |
| 12140290 |
Integrin alpha IIbbeta 3 has agonist-specific activation states and causes intrasubunit and intersubunit allosteric effects |
| 12750158 |
signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis. |
| 14499914 |
predictions of hydrophilicity, surface accessibility and antigenicity and the three dimensional structure of the beta(3) integrin correlate with autoantibody binding to a recombinant GPIIIa peptide 'B' containing residues 468-691. |
| 15131115 |
integrin alpha(IIb)beta3 adhesive function is regulated by platelet FXIII and calpain |
| 12358597 |
Data show clearly that integrin alpha(v)beta(3) interacts with the latency-associated peptide (LAPbeta1 and 3) RGD motif. |
| 12645863 |
decreased expression of endometrial integrin alphavbeta3 suggests that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility and recurrent IVF-ET failures |
| 12952967 |
beta3 integrin has a role in causing structural rearrangements of the 10-23 DNAzyme |
| 12690117 |
in megakaryocytes turbulence induces Rap1 activation that controls alphaIIbbeta3-mediated cell adhesion |
| 15609125 |
Inheritance of the integrin beta3 Leu33Pro polymorphism may increase the breast cancer risk by age 45 in the German population. |
| 15817799 |
This study provides evidence that ITGB3 plays a role in the pathogenesis of asthma and sensitization to mold allergens. |
| 15890274 |
electron tomography analysis of the three-dimensional structure of integrin alphaIIbbeta3 in the active state |
| 16228296 |
PI3K and granular released ADP in coordinating the feedback regulations in integrin alpha(IIb)beta3-mediated platelet activation |
| 16340127 |
the beta3 integrin gene is the direct target of NFAT1 in osteoclast formation |
| 16731529 |
integrin alpha3beta1 is a receptor for the alpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation |
| 16756721 |
binding of CXCL12 to its receptor leads to enhanced expression of alpha5 and beta3 integrins |
| 16723352 |
analysis of metal-binding sites in the integrin beta3 A-domain |
| 16790523 |
binding of resveratrol to integrin alphaVbeta3, principally to the beta3 monomer, is essential for transduction of the stilbene signal into p53-dependent apoptosis of breast cancer cells. |
| 17092301 |
results demonstrate differential modes of regulation of Dok1 and Dok2 in platelets, and raise the possibility that Dok2 plays an important role in integrin outside-in signaling through a physical and functional interaction with integrin alphaIIbbeta3 |
| 17203304 |
SLC6A4 and ITGB3 gene interactions have roles in autism etiology and in serotonin level determination |
| 17376438 |
This is the first demonstration that NO directly regulates integrin beta(3) phosphorylation. |
| 16385340 |
Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5) |
| 16357324 |
Outside-in signaling through integrin alpha2beta1 triggered inside-out activation of integrin alphaIIbbeta3 and promoted fibrinogen binding. (alpha2beta1 AND integrin alphaIIbbeta3 |
| 12198771 |
Integrin alphavbeta3. Expression of integrin alpha v beta 3 promotes the metastatic phenotype in human melanoma by supporting specific adhesive, invasive and migratory properties of the tumor cells |
| 11994301 |
Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton (integrin alpha(IIb)beta(3)) |
| 12049640 |
collagen receptor glycoprotein VI and alphaIIbbeta3 trigger distinct patterns of receptor signalling in platelets, leading to tyrosine phosphorylation of PLCgamma2 (integrin alphaiibbeta3) |
| 11934894 |
Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions (Integrin alpha-v beta-3) |
| 11959660 |
Del1 mediates vascular smooth muscle cell adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3). |
