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JAK1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18266209 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18270328 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18362173 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18178840 |
The structural integrity of both the FERM domain and of the kinase domain of JAK1 is essential for both receptor binding and catalytic function/autoinhibition |
| 12447867 |
Observational study of gene-environment interaction. (HuGE Navigator) |
| 17982039 |
two independent and indispensable signaling pathways-1) JAK1-associated PI3K signaling and 2) Act1/TRAF6/TAK1-mediated NF-kappaB activation-are stimulated by IL-17A to regulate gene induction in human airway epithelial cells. |
| 17641294 |
The results indicate that Adenovirus down-regulates host epithelial cell Jak1 to assure inhibition of the antiviral effects of multiple mediators to subvert airway defense responses and establish a productive infection. |
| 17686504 |
Mealse virus V protein can block the direct phosphorylation of STAT1 by Jak1 to escape IFN alpha/beta signaling. |
| 16767694 |
These results suggest that the JAK1-JH7-3 domains are required for interleukin-3 receptor common beta subunit interaction and abolish wild type JAK1 and JAK2-mediated signaling. |
| 16280321 |
JAK1/2 are client proteins of Hsp90 alpha and beta; Hsp90 and CDC37 play a critical role in types I and II interferon pathways | →View more information from publications. |
Recent Publications on JAK1: |  |
Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption.
Cadmium, mercury and rotenone are environmental pollutants whose... | 29th October, 2009
| Program in Neuroscience, School of Medicine and Biomedical Sciences,
| Neurotoxicology. 2009 Jul;30(4):589-98. Epub 2009 Apr 1.
DOI Direct Link |
Venezuelan equine encephalitis virus disrupts STAT1 signaling by distinct mechanisms independent of host shutoff.
Venezuelan equine encephalitis virus (VEEV) is an important human and... | 17th October, 2009
| Department of Genetics, University of North Carolina at Chapel Hill,
| J Virol. 2009 Oct;83(20):10571-81. Epub 2009 Aug 5.
DOI Direct Link |
Molecular mechanisms of IFN-gamma to up-regulate MHC class I antigen processing and presentation.
IFN-gamma up-regulates MHC class I expression and antigen processing and... | 9th October, 2009
| Diamantina Institute for Cancer Immunology and Metabolic Medicine,
| Int Rev Immunol. 2009;28(3-4):239-60.
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17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.
Constitutive activation of the Janus kinase (JAK)/signal transducer and... | 8th October, 2009
| Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese
| Cancer Res. 2009 Sep 15;69(18):7302-10. Epub 2009 Aug 25.
DOI Direct Link |
Cytokine expression and signaling in drug-induced cellular senescence.
Cellular senescence guards against cancer and modulates aging; however,... | 6th October, 2009
| [1] Department of Genome Integrity, Institute of Molecular Genetics,
| Oncogene. 2009 Oct 5.
DOI Direct Link |
→View more research publications. |
Press Releases on JAK1:
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| YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIA |
23rd November, 2009 |
YM BioSciences Inc. |
MISSISSAUGA, ON, Nov. 23 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI; TSX: YM), a life sciences product development company that identifies and advances a diverse portfolio of
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| YM BIOSCIENCES REPORTS CYT997 ORAL VASCULAR DISRUPTING AGENT RESULTS PRESENTED AT AACR-NCI-EORTC MEETING |
17th November, 2009 |
YM BioSciences Inc. |
MISSISSAUGA, ON, Nov. 17 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI; TSX: YM), a life sciences product development company that identifies and advances a diverse portfolio of
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| YM BIOSCIENCES REPORTS FISCAL FIRST QUARTER 2010 OPERATIONAL AND FINANCIAL RESULTS |
11th November, 2009 |
YM BioSciences Inc. |
MISSISSAUGA, ON, Nov. 11 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI, TSX: YM), a life sciences product development company that identifies and advances a diverse portfolio of
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JAK1 results (if any) from reagent suppliers | 
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