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JAK2


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Gene DB Home
Symbol:JAK2
Name(s):Janus kinase 2 (a protein tyrosine kinase)
Type:protein-coding
Organism:Homo sapiens
Synonyms:JTK10
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18055983 Eight mutation-positive cases were identified, including one with a previously undescribed mutant JAK2 exon 12 allele and another with biallelic involvement.
18056003 JAK2 exon 12 mutations were detected in 4 out of 20 polycythemia vera and idiopathic erythrocytosis V617F-negative patients and were only present in the myeloid lineage
18230964 observations suggest that the clinical phenotype of the JAK2 exon 12 mutation is partly different from that of the JAK2 V617F mutation
18092959 Higher haemoglobin and lower platelet levels in the JAK2 V617F mutation positive essential thrombocythemia patients.
18216871 Observational study of gene-disease association. (HuGE Navigator)
18239666 Observational study of gene-disease association. (HuGE Navigator)
18270328 Observational study of gene-disease association. (HuGE Navigator)
18294066 Observational study of genetic testing. (HuGE Navigator)
18297539 Observational study of genotype prevalence. (HuGE Navigator)
18306358 Observational study of genotype prevalence. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAngiotensin receptor 1Janus kinase 2--Pubmed
HPRDangiotensin II receptor, type 1Janus kinase 2--Pubmed
HPRDBCRJanus kinase 2--Pubmed
HPRDbreakpoint cluster region isoform 1Janus kinase 2--Pubmed
HPRDbreast cancer 1, early onset isoform 1Janus kinase 2--Pubmed
HPRDbreast cancer 1, early onset isoform 1Janus kinase 2--Pubmed
HPRDCC chemokine receptor 2Janus kinase 2--Pubmed
HPRDchemokine receptor 2 isoform AJanus kinase 2--Pubmed
HPRDchemokine receptor 5Janus kinase 2--Pubmed
HPRDchemokine receptor 5Janus kinase 2--Pubmed

Recent Publications on JAK2:

Pubmed Logo
Correlation of JAK2 V617F mutant allele quantitation with clinical presentation and type of chronic myeloproliferative neoplasm.
Activating JAK2 V617F mutation is present in many patients with chronic...
3rd November, 2009
Clinical Pathology Department, William Beaumont Hospital, Royal Oak, Ann Clin Lab Sci. 2009 Fall;39(4):345-50.
Hormonal control of luminescence from lantern shark (Etmopterus spinax) photophores.
The velvet belly lantern shark (Etmopterus spinax) emits a blue...
3rd November, 2009
Laboratory of Marine Biology, Catholic University of Louvain, B-1348 J Exp Biol. 2009 Nov;212(Pt 22):3684-92.
DOI Direct Link
JAK2 Gets Histone H3 Rolling.
Activation of JAK2 is implicated in normal hematopoiesis as well as...
3rd November, 2009
Department of Medicine, Brigham and Women's Hospital and Harvard Medical Cancer Cell. 2009 Nov 6;16(5):365-6.
DOI Direct Link
JAK2 V617F Mutation Detection: Laboratory Comparison of Two Kits Using RFLP and qPCR.
Aim: The JAK2 V617F mutation has been implicated in a variety of diseases...
3rd November, 2009
1 Department of Pathology & Laboratory Medicine, American University of Genet Test Mol Biomarkers. 2009 Oct 30.
DOI Direct Link
Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells.
Adipositas correlates with an enhanced risk of developing malignant...
31st October, 2009
Junior Research Group, Paul-Ehrlich-Institute, Langen, Germany. Int J Cancer. 2009 Oct 28.
DOI Direct Link

View more research publications.

Press Releases on JAK2:

BioPortfolio Logo
TargeGen Announces Successful Completion of Clinical Trial of JAK2 Inhibitor TG101348 in Myelofibrosis Patients 22nd October, 2009 TargeGen, Inc.

SAN DIEGO, Oct. 22 /PRNewswire/ -- TargeGen, Inc. today announced that the Company has successfully completed a 59 patient, multicenter clinical trial of TG101348, an oral, potent,

New Chromosomal Abnormality Identified in Leukemia Associated with Down Syndrome 18th October, 2009 St. Jude Children's Research Hospital

Study led by St. Jude Children's Research Hospital investigators expands understanding of acute lymphoblastic leukemia in children with Down syndrome, fueling hope

Cephalon Provides Clinical Update on Lestaurtinib in Relapsed Acute Myelogenous Leukemia 19th June, 2009 Cephalon, Inc.

FRAZER, Pa., June 19 /PRNewswire-FirstCall/ -- Cephalon, Inc. (Nasdaq: CEPH) today announced results from a pivotal clinical trial of lestaurtinib (CEP-701) in patients

Biomedical Sciences Companies Expanding in Asia Invested More Than US$500 Million in Singapore 18th May, 2009

ATLANTA, May 18 /PRNewswire/ -- Global biomedical sciences companies invested more than US$500 million in Singapore in the year 2008. This rides on Singapore's strong scientific

TargeGen Announces Successful Completion of Patient Enrollment in Clinical Trial of JAK2 Inhibitor TG101348 in Myelofibrosis Patients and Scheduled Presentation of Preliminary Trial Data at EHA Conference in Berlin 14th May, 2009 TargeGen, Inc.

SAN DIEGO, May 14 /PRNewswire/ -- TargeGen, Inc. today announced that the Company successfully completed enrollment of a multi-center clinical trial of TG101348, an oral, potent, and highly

BioNews Results for JAK2

: RSS Logo
BioPortfolio Logo
YM BioSciences announces offer for Cytopia Ltd
Bionity.com:  Oct 9 2009 9:03PM Matching: jak2
Enzyme Research: Research results from P.O. Hardy and colleagues update understanding of enzyme research
NewsRX:  Oct 9 2009 6:28PM Matching: jak2
YM BioSciences to Take Over Cytopia Gaining Base in Australia
Genetic Engineering News:  Oct 7 2009 10:41PM Matching: jak2
Absence of the V617F JAK2 Mutation in the Lymphoid Compartment in a Patient with Essential Thrombo- cythemia and B-Chronic Lymphocytic Leukemia and in Two Relatives with Lymphoproliferative Disorders
Oncology:  Oct 7 2009 10:06PM Matching: jak2
Ym Biosciences Announces Offer For Cytopia Ltd., An Australian Cancer-focused Development Company
Genetic Engineering News:  Oct 6 2009 6:22PM Matching: jak2
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Phase II Study of GIVINOSTAT (ITF2357) in Combination With Hydroxyurea in Polycythemia Vera

Patents:

Patents logo
US Patent No.Title
7507826 Azaindoles useful as inhibitors of JAK and other protein kinases
7534792 Pyrrolotriazine kinase inhibitors
7541367 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
7547515 Methods for detection of the Ob receptor and the diagnosis of body weight disorders, including obesity and cachexia
7547687 Therapeutic treatment methods

View more patents.

JAK2 results (if any) from reagent suppliers

Google CSE Logo
Phospho-Jak2 (Tyr1007/1008) Antibody #3771
Phospho-Jak2 (Tyr1007/1008) Antibody detects endogenous levels of Jak2 only when phosphorylated at tyrosine 1007/1008. This antibody may cross-react with ...
http://www.cellsignal.com/products/3771.html...

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JAK2 antibody (ab39636) | Abcam
Rabbit polyclonal to JAK2. JAK2 (Janus Activating Kinase 2) is a tyrosine kinase of the non-receptor type, that associates with the intracellular domains of ...
http://www.abcam.com/JAK2-antibody-ab39636.html...

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Phospho-Jak2 (Tyr221) Antibody #3774
Western blot analysis of extracts from HT29 and CTLL2 cells, untreated or treated with IL-4 or GM-CSF (10 minutes), using Phospho-Jak2 (Tyr221) Antibody.
...
http://www.cellsignal.com/products/3774.html...

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The Abcam catalog
JAK2 antibodies. ... Image Abreview Publication. ab68268 · JAK2 (phospho Y1007 + Y1008) antibody. IP, WB, I-ELISA, Dot. Images. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=7324&pt=1&c=3500...

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Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody
Polyclonal Antibody against Phospho-JAK2 (Tyr221) for use in Immunohistochemistry.
http://www.bioreagents.com/products/productDetails/productDe...

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JAK2 antibody [691R5] (ab37226) | Abcam
Mouse monoclonal [691R5] to JAK2. JAK2 (Janus Activating Kinase 2) is a tyrosine kinase of the non-receptor type, that associates with the intracellular ...
http://www.abcam.com/JAK2-antibody-691R5-ab37226.html...

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p-JAK2 (Tyr 1007/Tyr 1008) Antibody sc-21870
The Src tyrosine kinase Hck is required for Tel-Abl- but not for Tel-Jak2- induced cell transformation. Oncogene. 26: 1577–1585. View PubMed Entry ...
http://www.scbt.com/datasheet-21870-p-jak2-tyr-1007-tyr-1008...

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