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JAK3
| Symbol: | JAK3 | | Name(s): | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17938255 |
the effect of IL-15 and IL-21, which are closely related to IL-2 and share the usage of the common gamma chain and of its JAK3-associated pathway. |
| 14726805 |
Meta-analysis and HuGE review of genotype prevalence, gene-disease association, genetic testing, and healthcare-related. (HuGE Navigator) |
| 17537734 |
a novel pathway in intestinal enterocytes in which IL-2 enhances intestinal wound repair through mechanisms involving Jak3 and its interactions with villin. |
| 16790275 |
The transforming activity of JAK3(V674A) was confirmed by its introduction into 32Dcl3-mCAT. Sequencing of the original JAK3 cDNA derived from the patient, however, failed to detect the V674A mutation. |
| 16192633 |
Inhibition of JAK3 signaling in colon carcinoma tumors and cell lines induces apoptosis and cell cycle arrest of colon carcinoma cells. |
| 17081797 |
These results suggest that oncostatin M inhibits adiponectin expression by inducing dedifferentiation of adipocytes through signaling pathways involving JAK3 and MEK, but not JAK2. |
| 12777975 |
Data suggest there is no defect in the JAK/STAT pathway in the tested melanoma cell lines, and that interferon resistance must be mediated through other components. |
| 15611059 |
CXCL12 signaling is independent of Jak2 and Jak3 |
| 12207328 |
JAK3 is associated with a pre-phosphorylated IL-4Ralpha and CD40. This novel "heterotrimer" (p-IL-4Ralpha, CD40/JAK3) is functional and controls STAT3 phosphorylation and CD40 expression. |
| 16153455 |
We conclude that Jak3 activation is predominantly restricted to ALK-positive ALCL tumors. Most likely. | →View more information from publications. |
Recent Publications on JAK3: |  |
Monitoring of the immunomodulatory effect of CP-690,550 by analysis of the JAK/STAT pathway in kidney transplant patients.
BACKGROUND.: The small molecule drug CP-690,550 inhibits Janus kinase 3 at... | 27th October, 2009
| Erasmus MC, University Medical Center Rotterdam, Internal
| Transplantation. 2009 Oct 27;88(8):1002-9.
DOI Direct Link |
2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.
A novel class of Janus tyrosine kinase 3 (JAK3) inhibitors based on a... | 20th October, 2009
| Ligand Pharmaceuticals, Inc., 3000 Eastpark Boulevard, Cranbury, NJ 08512,
| Bioorg Med Chem Lett. 2009 Sep 25.
DOI Direct Link |
JAK3 Inhibitors in Organ Transplantation and Autoimmune Disease.
Janus kinase 3 (JAK3) is a cytoplasmic tyrosine kinase associated with the... | 17th October, 2009
| Laboratory of Experimental Surgery, Department of Surgery, Research
| Recent Pat Inflamm Allergy Drug Discov. 2009 Oct 16.
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MS-1020 is a novel small molecule that selectively inhibits JAK3 activity.
In order to identify Janus kinase/signal transducer and activator of... | 2nd October, 2009
| Pediatrics-Hematology/Oncology, New York Medical College, Valhalla, NY,
| Br J Haematol. 2009 Sep 29.
DOI Direct Link |
Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain.
Janus-associated kinases (JAKs) play critical roles in cytokine signaling,... | 29th September, 2009
| Pfizer Inc., Global Research and Development, St. Louis Laboratories, 700
| Protein Expr Purif. 2009 Sep 23.
DOI Direct Link |
→View more research publications. |
JAK3 results (if any) from reagent suppliers | 
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