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JUNB


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Symbol:JUNB
Name(s):jun B proto-oncogene
Type:protein-coding
Organism:Homo sapiens
Synonyms:AP-1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17495958 Coordinated down- and up-regulation of the various AP-1 subunits in the course of epidermal wound healing is important for its undisturbed progress, putatively by influencing inflammation and cell-cell communication.
17965727 constitutive action of aberrantly expressed JunB on hypomethylated CD30 CpG islands of lymphocytes triggers CD30 induction and initiates activation of the JunB-CD30-JunB loop, essential to the pathogenesis of HL and ALCL
17690253 JunB is a critical target of mTOR and is translationally regulated in NPM-ALK-positive lymphomas.
17681951 Dimerization with the Jun proteins inhibits c-Fos nuclear exit.
17306025 results suggest that HTLV-I HBZ-SP1- mediated sequestration of JunB to the HBZ-SP1 nuclear bodies may be causing the repression of JunB activity in vivo
12522006 C/EBPalpha and PKC/delta affect expression of this gene and monocyte differentiation.
12393503 results have revealed, for the first time, amplification and expression patterns of JUNB in primary cutaneous lymphomas
12145210 Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
12080089 JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction
16552541 The IGFBP3, hRas, JunB, Egr-1, Id1 and MIDA1 genes were up-regulated in psoriatic involved skin compared with uninvolved skin.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDB-cell lymphoma 6 proteinjun B proto-oncogene--Pubmed
HPRDB-cell lymphoma 6 proteinjun B proto-oncogene--Pubmed
HPRDbreast cancer 1, early onset isoform 1jun B proto-oncogene--Pubmed
HPRDbreast cancer 1, early onset isoform 1jun B proto-oncogene--Pubmed
BINDbreast cancer 1, early onset isoform 1jun B proto-oncogeneBRCA1 interacts with JunB.-Pubmed
BINDestrogen receptor 1jun B proto-oncogeneER-alpha interacts with JunB. This interaction was modeled on a demonstrated interaction between human ER-alpha and mouse JunB.-Pubmed
HPRDc-Fosjun B proto-oncogene--Pubmed
HPRDv-fos FBJ murine osteosarcoma viral oncogene homologOncogene Jun-B--Pubmed
HPRDFBJ murine osteosarcoma viral oncogene homolog Bjun B proto-oncogene--Pubmed
HPRDFBJ murine osteosarcoma viral oncogene homolog Bjun B proto-oncogene--Pubmed

Recent Publications on JUNB:

Pubmed Logo
Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T(H)2 lineage commitment.
How naive CD4(+) T cells commit to the T helper type 2 (T(H)2) lineage is...
3rd November, 2009
Department of Immunology, MD Anderson Cancer Center, Houston, Texas, USA. Nat Immunol. 2009 Nov 1.
DOI Direct Link
Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma.
Heparan sulfate proteoglycan syndecan-1, CD138, is well known to be...
29th October, 2009
Department of Pathology, Nara Medical University School of Medicine, Nara, Cancer Sci. 2009 Oct 6.
DOI Direct Link
c-Jun-NH(2) terminal kinase (JNK)-mediates AP-1 activation by thioredoxin: phosphorylation of cJun, JunB, and Fra-1.
Thioredoxin (Trx) is a small ubiquitous protein, which has been shown to...
28th October, 2009
Department of Pathology, University of Arkansas for Medical Sciences, 4301 Mol Cell Biochem. 2009 Oct 27.
DOI Direct Link
Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappaB, HIF-1alpha, and AP-1.
Chronic alcohol consumption leads to liver inflammation and cirrhosis....
16th October, 2009
Department of Biochemistry and Molecular Biology, Keck School of Medicine, J Immunol. 2009 Nov 1;183(9):5964-76. Epub 2009 Oct 14.
DOI Direct Link
The arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1.
Dmp1 (Dmtf1) encodes a Myb-like transcription factor implicated in tumor...
10th October, 2009
The Departments of Pathology, Wake Forest University Health Sciences, Int J Cancer. 2009 Oct 8.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
S-1 and Photodynamic Therapy in Cholangiocarcinoma

Patents:

Patents logo
US Patent No.Title
7371207 Estrogen receptor .alpha. regulated gene expression, related assays and therapeutics
7459282 Use of c-Jun or c-Jun activating agents such as UV or c-Jun N-terminal kinases (JNKs) for treating cancer
7462457 Identification of activated receptors and ion channels
7468178 Methods for identifying compounds that modulate vigilance states
7468251 Compositions for detection of A target nucleic acid sequence

View more patents.

JUNB results (if any) from reagent suppliers

Google CSE Logo
JunB antibody (ab11981) | Abcam
Rabbit polyclonal to JunB. The cJun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus vjun oncogene. JunB and JunD have
...
http://www.abcam.com/JunB-antibody-ab11981.html...

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p-Jun B (Ser 259) Antibody sc-101724
Western blot analysis of phosphorylated Jun B expression in HeLa whole cell ... Blots were probed with p-Jun B (Ser 259): sc-101724 (A) p-Jun B (Ser 259): ...
http://www.scbt.com/datasheet-101724-p-jun-b-ser-259-antibod...

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The Abcam catalog
JunB antibodies. ... Image Abreview Publication. ab30628 · JunB (phospho S259) antibody. IHC-P, WB, ELISA, IP. Images. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=11339&pt=1&c=915...

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Jun B (C-11) Antibody sc-8051
See how others have used Jun B (C-11): sc-8051 antibody and or Jun B (C-11) ... Western blot analysis of Jun B expression in non-transfected: sc-117752 (A) ...
http://www.scbt.com/datasheet-8051-jun-b-c-11-antibody.html...

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JunB (P169) Antibody
corresponding to residues surrounding Pro169 of human JunB. ... Confocal immunofluorescent analysis of HeLa cells using JunB. (P169) Antibody (green).
...
http://www.cellsignal.com/pdf/3755.pdf...

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Jun B (N-17) Antibody sc-46
See how others have used Jun B (N-17): sc-46 antibody and or Jun B (N-17) antibody ... Western blot analysis of Jun B in nuclear extract of phorbol ...
http://www.scbt.com/datasheet-46-jun-b-n-17-antibody.html...

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Anti-JunB antibody produced in rabbit (J106) - Datasheet
Anti-JunB was developed by immunizing rabbits with a ... Recommended starting titer for Anti-JunB is 10 µl/ml for immunoblotting. ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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