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KARS


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Symbol:KARS
Name(s):lysyl-tRNA synthetase
Type:protein-coding
Organism:Homo sapiens
Synonyms:KARS2, KIAA0070, KRS
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18272479 present a 2.3-A crystal structure of a tetrameric form of human LysRS
17724017 This work reports further characterization of the interaction between HIV-1 capsid domain of Gag and human LysRS using truncation constructs and point mutations in the putative interaction helices.
12756246 HIV-1 Gag interacts with human lysyl-tRNA synthetase during viral assembly
16702215 analysis of the interaction between HIV-1 Gag and human lysyl-tRNA synthetase
15220430 packaged into human immunodeficiency virus type 1 (HIV-1) via its interaction with Gag; this enzyme facilitates the selective packaging of tRNA(3)(Lys), the primer for initiating reverse transcription, into HIV-1
17560997 HIV-1 Vpr fulfills an essential role in the process of packaging of mitochondrial Lysyl-tRNA synthase.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDLysyl tRNA synthetasemethionyl-tRNA synthetase--Pubmed
HPRDHomo sapiens lysyl-tRNA synthetase mRNA, complete cdsMethionyl tRNA synthetase--Pubmed
HPRDHomo sapiens lysyl-tRNA synthetase mRNA, complete cdstRNA synthetase cofactor p38--Pubmed
HPRDHomo sapiens lysyl-tRNA synthetase mRNA, complete cdsJTV1--Pubmed
BINDlysyl-tRNA synthetaseJTV1p38 interacts with LysRS.-Pubmed

Recent Publications on KARS:

Pubmed Logo
Cavernous hemangioma: a rare cause for secondary parkinsonism: a case report.
A 72-year-old female was admitted to our outpatient clinic with the...
30th October, 2009
Faculty of Medicine, Department of Neurology, Kafkas University, Kars, Int J Neurosci. 2009;119(11):2112-7.
Functional and clinical evaluation for the surgical treatment of degenerative stenosis of the lumbar spinal canal.
OBJECT: This study was designed to evaluate the efficacy of decompressive...
30th October, 2009
Second Neurosurgery, Diskapi Yildirim Beyazit Training and Research J Neurosurg Spine. 2009 Sep;11(3):347-52.
DOI Direct Link
Case report. Isolated complete congenital sternal cleft in an adult: MDCT imaging findings.
Sternal cleft is a very rare midline defect. Incomplete forms are more...
29th October, 2009
Sarikamis Military Hospital, Department of Radiology, Sarikamis, Kars, Br J Radiol. 2009 Oct;82(982):e202-3.
DOI Direct Link
Detection of KRAS oncogene in peripheral blood as a predictor of the response to cetuximab plus chemotherapy in patients with metastatic colorectal cancer.
PURPOSE: Previously we developed membrane-arrays as a promising tool to...
20th October, 2009
Graduate Institute of Medicine, College of Medicine, College of Medicine, Clin Cancer Res. 2009 Jul 1;15(13):4508-13. Epub 2009 Jun 23.
DOI Direct Link
Ion-Dependent Gating of Kainate Receptors.
Ligand-gated ion-channels are an important class of signalling protein...
14th October, 2009
McGill University Medical School. J Physiol. 2009 Oct 12.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Pharmacogenetic Study of Methylphenidate in Attention Deficit/Hyperactivity Disorder(ADHD)

Patents:

Patents logo
US Patent No.Title
7098493 MRAM in-pixel memory for display devices
7250278 .alpha.-keto acid reductase, method for producing the same, and method for producing optically active .alpha.-hydroxy acids using the same
7279461 Rabconnectin-3-binding protein
7282356 D-aminoacylase mutants
7287662 Closure plug improvement

View more patents.

KARS results (if any) from reagent suppliers

Google CSE Logo
KARS (Lysyl-tRNA synthetase) Antibody (C-term)
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with KARS antibody (C-term) (Cat.#AP7833b), which was peroxidase-conjugated to the
...
http://www.abgent.com/products/catalog_no/AP7833b_KARS_Lysyl...

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Grik4 Antibody (CT) The KA1 subunit of kainate-type ionotropic ...
Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by ... In the adult brain, KARs are located pre- and postsynaptically on pyramidal ...
http://www.prosci-inc.com/shop/catalog1/Grik4-Antibody-p-660...

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KA1 antibody (ab10101) | Abcam
KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of KA1 with both schizophrenia and bipolar
...
http://www.abcam.com/KA1-antibody-ab10101.html...

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LysRS (F-25) Antibody sc-130806
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KARS, 3735, 16q23.1, Q15046 ...
http://www.scbt.com/datasheet-130806-lysrs-f-25-antibody.htm...

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Site Map Bethyl Laboratories
KARS · Kendrin/Pericentrin · Ki-67 · KIAA0082 · KIAA0310 · KIAA0460 · KIAA0528 · KIAA1276 · KIAA1794/FLJ10719 · KID/KIF22 · KIF10/CENP-E · KIF11/EG5 ...
http://www.bethyl.com/content/sitemap...

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LysRS siRNA (m) sc-75719
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. マウス, Kars, 85305, 8 E1, Q99MN1 ...
http://www.scbt.com/ja/datasheet-75719-lysrs-sirna-m.html...

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LysRS (Y-21) Antibody sc-133766
... Localisation chromosomique, Numéro d'accès d´isoforme d´ARNm, Numéro d'accès de la protéine, Numéro OMIM™. Humain, KARS, 3735, 16q23.1, Q15046 ...
http://www.scbt.com/fr/datasheet-133766-lysrs-y-21-antibody....

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