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KCNA2
| Symbol: | KCNA2 | | Name(s): | potassium voltage-gated channel, shaker-related subfamily, member 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | HBK5, HK4, HUKIV, KV1.2, MGC50217, MK2, NGK1, RBK2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18003609 |
Kv1.2 levels at the cell surface are kept in dynamic balance by opposing effects of cAMP |
| 18042681 |
Replacement of the N-terminal domain of maurotoxin by the one of the Agitoxin 2 chimera results in reorganization of disulfide bridge arrangements and increase of affinity to the Kv1.2 channel. |
| 17959782 |
Kv1.2 and cortactin interact in vivo |
| 17576778 |
MK2-HSP27 pathway regulates the NF-kappaB transcriptional output by switching the activation pattern from high level to low level. |
| 15215309 |
endocytosis of Kv1.2 from the cell surface is a key mechanism for channel suppression by tyrosine kinases |
| 17234891 |
our results demonstrate the multiplicity of gating inhibition of different K(v) channels by Syn-1A and is compatible with versatility of Syntaxin-1A modulation of repolarization in various secretory and nonsecretory (smooth muscle) cell types. |
Recent Publications on KCNA2: |  |
Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons.
Genes Kcna1 and Kcna2 code for the voltage-dependent potassium channel... | 8th January, 2008
| Virginia Merrill Bloedel Hearing Research Center, Box 357923, University
| J Neurophysiol. 2007 Sep;98(3):1501-25. Epub 2007 Jul 18.
DOI Direct Link |
Sleep in Kcna2 knockout mice.
BACKGROUND: Shaker codes for a Drosophila voltage-dependent potassium... | 5th January, 2008
| Department of Psychiatry, University of Wisconsin, Madison, WI, 53719,
| BMC Biol. 2007 Oct 9;5:42.
DOI Direct Link |
Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats.
Small coronary arteries (SCA) from diabetic rats exhibit enhanced... | 6th December, 2007
| Department of Medicine, The Medical College of Wisconsin, Milwaukee,
| Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2231-7. Epub 2007 Aug 3.
DOI Direct Link |
Inherited neuromyotonia: a clinical and genetic study of a family.
Neuromyotonia is a disorder of peripheral nerve hyperexcitability... | 18th April, 2007
| Neuromuscular and Neurodegenerative Disease Unit, University of Genova, G
| Neuromuscul Disord. 2007 Jan;17(1):23-7. Epub 2006 Nov 30.
DOI Direct Link |
Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells.
Activity of voltage-gated K(+) (K(V)) channels in pulmonary artery smooth... | 9th December, 2006
| Department of Medicine, Division of Pulmonary and Critical Care Medicine,
| Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L993-1004. Epub 2006
DOI Direct Link |
→View more research publications. |
KCNA2 results (if any) from reagent suppliers | 
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KV1.2 (S-14) Antibody sc-11188
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KCNA2, 3737, 1p13.3, NM_004974 ...
http://www.scbt.com/datasheet-11188-kv1-2-s-14-antibody.html...
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Complete Solutions for Ion Channels
KCNA2, NM_004974, potassium voltage-gated channel: shaker-related subfamily: member 2, P8732. KCNA3, NM_002232, potassium voltage-gated channel: ...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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KV1.2 (S-14) Antibody sc-11188
Humano, KCNA2, 3737, 1p13.3, NM_004974 · P16389 · 176262. Ratón, Kcna2, 16490, 3 F2.3, P63141, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-11188-kv1-2-s-14-antibody.h...
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Potassium Channel Blockers EconoKit #EK-300
and KCNA2 channels. Castle, N.A. et al. (2003) Mol. Pharmacol. 63, 409. MCD- Peptide (M-250). 0.1 mg (>98%). 2478. Water. R.T.: 3 weeks. -20°C: 2 years ...
http://www.alomone.com/system/UpLoadFiles/DGallery/Docs/ek-3...
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KV1.2 (S-14) Antibody sc-11188
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, KCNA2, 3737, 1p13.3, NM_004974 ...
http://www.scbt.com/ja/datasheet-11188-kv1-2-s-14-antibody.h...
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Potassium Channel Modulators
It blocks voltage-gated potassium channels (KV1.1/KCNA1, KV1.2/KCNA2, and KV1.3/ KCNA3) and inhibits apamin-sensitive small conductance calcium-activated ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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KV1.2 (S-14) Antibody sc-11188
Spezies, Gen, Gen ID, Chromosomaler Locus, mRNA (Isoform) Accession #, Protein Accession #, OMIM™ Nummer. Human, KCNA2, 3737, 1p13.3, NM_004974 · P16389 ...
http://www.scbt.com/de/datasheet-11188-kv1-2-s-14-antibody.h...
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