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KCNA3
| Symbol: | KCNA3 | | Name(s): | potassium voltage-gated channel, shaker-related subfamily, member 3 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16317062 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17854350 |
The Kv1.3 potassium channel, postsynaptic density protein 95, and insulin receptor serine kinase co-localize to regulate membrane excitability and synaptic transmission at critical locations in the olfactory bulb. |
| 17878353 |
Specific Kv1.3 blockers may be beneficial in autoimmune diseases such as multiple sclerosis in which effector memory T cells are found in the target organ |
| 17582781 |
Ketanserin acts directly on the open state of the Kv1.3 channel, reducing current flow. Augmentation of extracellular [K] enhances current flow through the channel. |
| 17242956 |
Cholesterol depletion causes significant, reversible alterations in the Kv1.3 channel function in Jurkat cells. |
| 12909584 |
Of 13 voltage-gated K+ (Kv) potassium channels sought, only Kv1.3 mRNA was present. Kv1.3 sets the resting potential of the cells, but it is not required for Fc receptor-mediated phagocytosis. |
| 12807917 |
Fas ligand increases Kv1.3 channel activity through the same canonical apoptotic signaling cascade that is required for potassium efflux, cell shrinkage, and apoptosis |
| 17088564 |
T cells with other antigen specificities from these patients, or autoreactive T cells from healthy individuals and disease controls, express low levels of Kv1.3 and are predominantly naive or central-memory (T(CM)) cells |
| 12632187 |
manipulation of membrane cholesterol changed both the kinetic properties of Kv1.3 and steady-state parameters of activation by modifying lipid-protein interactions. |
| 12850541 |
In different glioma samples investigated for expression of KV1.3 potassium channels, no correlation of expression with glioma entities and malignancy grades is evident for KV1.3. | →View more information from publications. |
Recent Publications on KCNA3: |  |
Effect of K+ and Rb+ on the action of verapamil on a voltage-gated K+ channel, hKv1.3: implications for a second open state?
BACKGROUND AND PURPOSE: Verapamil blocks current through the voltage-gated... | 14th October, 2009
| Institute of Applied Physiology, Ulm University, Ulm, Germany.
| Br J Pharmacol. 2009 Jul;157(5):757-68. Epub 2009 Apr 9.
DOI Direct Link |
Functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse.
Formation of immunological synapse (IS), the interface between T cells and... | 25th September, 2009
| Department of Biophysics and Cell Biology, Medical and Health Science
| Immunol Lett. 2009 Jun 30;125(1):15-21. Epub 2009 May 27.
DOI Direct Link |
Monocyte chemotactic protein-1 regulates voltage-gated K+ channels and macrophage transmigration.
Progressive human immunodeficiency virus (HIV)-1 infection and... | 12th May, 2009
| Center for Neurovirology and Neurodegenerative Disorders, Department of
| J Neuroimmune Pharmacol. 2009 Mar;4(1):47-59. Epub 2008 Nov 26.
DOI Direct Link |
Blockade action of ketanserin and increasing effect of potassium ion on Kv1.3 channels expressed in Xenopus oocytes.
The goal of this study was to investigate the pharmacological effects of... | 2nd November, 2007
| Department of Cardiology, Institute of Cardiovascular Diseases, Ion
| Pharmacol Res. 2007 Aug;56(2):148-54. Epub 2007 May 16.
DOI Direct Link |
Phylogenomic analyses of KCNA gene clusters in vertebrates: why do gene clusters stay intact?
BACKGROUND: Gene clusters are of interest for the understanding of genome... | 27th September, 2007
| Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology,
| BMC Evol Biol. 2007 Aug 15;7:139.
DOI Direct Link |
→View more research publications. |
KCNA3 results (if any) from reagent suppliers | 
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KV1.3 (C-15) Antibody sc-17241
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KCNA3, 3738, 1p13.3, NM_002232 ...
http://www.scbt.com/datasheet-17241-kv1-3-c-15-antibody.html...
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P9107 Anti-Potassium Channel Kv1.3 (Charybdotoxin-Sensitive ...
immunocytochemistry: 1:50 using cells permeabilized with 0.2% Triton X-100. Gene Information, human ... KCNA3(3738). rat ... Kcna3(29731) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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Anti-Kv1.3 (extracellular)
(Voltage-gated potassium channel Kv1.3, Kcna3). Product #: APC-101. Current Lot #: AN-06, AN-07, AN-08, AN-09. Host: Rabbit. Type: Polyclonal. ...
http://www.alomone.com/System/UpLoadFiles/DGallery/Docs/APC-...
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Complete Solutions for Ion Channels
KCNA3, NM_002232, potassium voltage-gated channel: shaker-related subfamily: member 3, P9107 · P4497 · P4247. KCNA4, NM_021275, potassium voltage-gated ...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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Regulating the Immune Response
channel KV1.3, Kcna3). Product #: APC-101. Host: Rabbit. Epitope: Peptide KDYPASTSQDSFEA(C) corresponding to residues 211-224 of human Kv1.3. ...
http://www.alomone.com/system/UpLoadFiles/DGallery/Docs/immu...
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KV1.3 siRNA (m) sc-42713
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Kcna3, 16491, 3 F2.3, P16390 ...
http://www.scbt.com/datasheet-42713-kv1-3-sirna-m.html...
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Abcam antibodies and reagents product map
... Importin 13 antibodies (1) · Importin 13 proteins and peptides (1) · KCNA10 antibodies (2) · KCNA3 antibodies (4) · KCNF1 antibodies (1) ...
http://www.abcam.com/index.html?cl=2105&pageconfig=productma...
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