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KCNA4
| Symbol: | KCNA4 | | Name(s): | potassium voltage-gated channel, shaker-related subfamily, member 4 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12065763 |
N-type inactivation in hKv1.4 is regulated by pH(i) in the physiologic range through ionization of specific amino acid residues in the ball domain. |
| 15136567 |
Results describe an erbstatin (Erb) analogue as a small molecule inhibitor of the N-type inactivation in potassium channels Kv1.4 and Kv1.1+Kvbeta1. |
| 16308273 |
Fast inactivation in human Kv1.4 is modulated by structural elements in the C-terminus, suggesting that the process involves the concerted action of the N- and C-termini. |
| 17156368 |
The results demonstrate that the human Kvbeta1.1 and Kvbeta1.2 subunits regulate the proportion of wild-type Kv1.4-1.1 channels that are available to open. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | discs, large homolog 1 | Potassium channel, voltage gated, shaker related subfamily, member 4 | - | - | Pubmed |
| HPRD | chapsyn-110 | Potassium channel, voltage gated, shaker related subfamily, member 4 | - | - | Pubmed |
| HPRD | postsynaptic density protein 95 | Potassium channel, voltage gated, shaker related subfamily, member 4 | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, shaker-related subfamily, member 4 | discs large homolog-associated protein 1 isoform alpha | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, shaker-related subfamily, member 4 | syntrophin, gamma 1 | - | - | Pubmed |
Recent Publications on KCNA4: |  |
Divergent regulation of cardiac KCND3 potassium channel expression by the thyroid hormone receptors alpha1 and beta1.
The cardiac transient outward current I(to) is regulated by thyroid... | 12th May, 2009
| Department of Internal Medicine III, University of Cologne, Kerpener Str.
| J Physiol. 2009 Mar 15;587(Pt 6):1319-29. Epub 2009 Jan 26.
DOI Direct Link |
Genomic imbalances in key ion channel genes and telomere shortening in sudden cardiac death victims.
Sudden cardiac death (SCD) can be caused by a number of reasons. Previous... | 12th March, 2009
| Department of Physiology, Yong Loo Lin School of Medicine, National
| Cytogenet Genome Res. 2008;122(3-4):350-5. Epub 2009 Jan 30.
DOI Direct Link |
Identification of an evolutionarily conserved extracellular threonine residue critical for surface expression and its potential coupling of adjacent voltage-sensing and gating domains in voltage-gated potassium channels.
The dynamic expression of voltage-gated potassium channels (Kvs) at the... | 30th December, 2008
| Faculty of Life Sciences, University of Manchester, Manchester M13 9PN,
| J Biol Chem. 2008 Oct 31;283(44):30421-32. Epub 2008 Jul 18.
DOI Direct Link |
Autosomal dominant lateral temporal epilepsy: absence of mutations in ADAM22 and Kv1 channel genes encoding LGI1-associated proteins.
Mutations in the LGI1 gene are linked to autosomal dominant lateral... | 9th October, 2008
| CNR-Institute of Neurosciences, Section of Padua, Padova, Italy.
| Epilepsy Res. 2008 Jul;80(1):1-8. Epub 2008 Apr 28.
DOI Direct Link |
Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2.
Episodic ataxia type 1 (EA1) is an autosomal dominant neurological... | 24th February, 2007
| University of Perugia School of Medicine, Department of Internal Medicine,
| Eur J Neurosci. 2006 Dec;24(11):3073-83.
DOI Direct Link |
→View more research publications. |
KCNA4 results (if any) from reagent suppliers | 
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KV1.4 (F-20) Antibody sc-16179
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KCNA4, 3739, 11p14.1, NM_002233 ...
http://www.scbt.com/datasheet-16179-kv1-4-f-20-antibody.html...
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Complete Solutions for Ion Channels
KCNA4, NM_021275, potassium voltage-gated channel: shaker-related subfamily: member 4, P9232. KCNA5, NM_002234, potassium voltage-gated channel: ...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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KV Antibody / KV Antibodies
製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. KVβ.1 (C-13) 抗体, sc-51104, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, h, cow ...
http://www.scbt.com/ja/table-kv.html...
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KV1.4 (F-20) Antibody sc-16179
Humano, KCNA4, 3739, 11p14.1, NM_002233 · P22459 · 176266. camundongo, Kcna4, 16492, 2 E3, Q61423, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-16179-kv1-4-f-20-antibody.h...
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KV1.4 (F-20) Antibody sc-16179
Spezies, Gen, Gen ID, Chromosomaler Locus, mRNA (Isoform) Accession #, Protein Accession #, OMIM™ Nummer. Human, KCNA4, 3739, 11p14.1, NM_002233 · P22459 ...
http://www.scbt.com/de/datasheet-16179-kv1-4-f-20-antibody.h...
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KV1.4 (F-20) Antibody sc-16179
种属, 基因名称, 基因ID, 染色质位置, 亚型（mRNA）即位号码, 蛋白质即位号码, OMIM™ 号码. 人类, KCNA4, 3739, 11p14.1, NM_002233 · P22459 ...
http://www.scbt.com/zh/datasheet-16179-kv1-4-f-20-antibody.h...
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