Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18045238 |
amphiregulin-specific EGF-R fate results from decreased hSprouty2 degradation and reduced Cbl recruitment to underphosphorylated EGF-R, two effects that impair EGF-R trafficking to lysosomes |
| 17942395 |
After exposure to cisplatin, the resistant breast cancer cells secrete amphiregulin protein by short interfering RNA resulting in a nearly complete reversion of the resistant phenotype. |
| 17962208 |
AREG is preferentially expressed in breast tumors co-expressing HER2/HER4. AREG is associated with estradiol receptors, small tumour size, low histoprognostic grading, high HER4 levels. |
| 17525275 |
AREG is up-regulated in tumor cells of SCC but not BCC of the skin. AREG is also overexpressed in asymptomatic epidermis adjacent to both SCC and BCC, relative to normal skin. |
| 16470170 |
Amphiregulin and HB-EGF mediate retinoic acid-mediated epidermal hyperplasia |
| 16336275 |
HAT induces amphiregulin production through the PAR-2 mediated ERK pathway, and then causes amphiregulin release by a TACE-dependent mechanism |
| 15696081 |
Amphiregulin was secreted by human mast cells after aggregation of FcepsilonRI. Amphiregulin may be new target molecule for treatment of overproduction of sputum in bronchial asthma. |
| 15696083 |
Mast cells secreted amphiregulin on IgE cross-linking, and amphiregulin induced proliferation of lung fibroblasts. Local release of amphiregulin by mast cells could play role in lung fibrosis by promoting proliferation of lung fibroblasts. |
| 16888076 |
findings demonstrated that PGE2 may mimic LH action at least in part by the activation of amphiregulin and epiregulin biosynthesis in human granulosa cells |
| 12356750 |
H358 cells secrete a high level of amphiregulin that, in combination with IGF1, prevents serum deprivation apoptosis |
| 12743035 |
Data show that in squamous cell carcinoma cells, stimulation with G protein-coupled receptor agonists specifically results in cleavage and release of amphiregulin (AR) by TACE. |
| 12711607 |
amphiregulin binds to EGF receptor and has a role in stimulation of lung epithelial cells upon exposure to tobacco smoke |
| 15767261 |
AR and IGF1 cooperate to prevent apoptosis by activating a specific PKC-p90(rsk)-dependent pathway, which leads to Bad and Bax inactivation. |
| 16641105 |
results show that TACE undergoes phosphorylation that regulates release of amphiregulin upon GRP treatment; a signaling cascade of GRP-Src-PI3-K-PDK1-TACE-amphiregulin-EGFR with multiple points of interaction, translocation & phosphorylation is suggested |
| 11859273 |
mRNA expression in atrophic gastritis before and after Helicobacter pylori eradication |
| 15254267 |
amphiregulin- and ErbB1-dependent mechanism by which autocrine ERK activation is maintained in normal keratinocytes |
| 15474502 |
upregulation of the epiregulin and amphiregulin expression is part of the signal transduction pathway which leads to ovulation and luteinization in the human ovary |
| 15735670 |
AREG gene expressed by purified primary myeloma cells, and expression higher than in normal bone marrow (BM) plasma cells or plasmablastic cells; AREG plays an important role in biology of multiple myeloma |
| 11719440 |
(TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin. |
| 15186320 |
epidermal AR expression as a possible mediator of innate cutaneous immunity and epidermal proliferation and also as a potential trigger of both cutaneous psoriasis and psoriatic arthritis. |
| 15685553 |
an early-response growth factor that may contribute to the initial phases of liver regeneration. |
| 16088955 |
Data suggest that parathyroid hormone-induced amphiregulin mRNA expression is mediated primarily through cyclic AMP-protein kinase A-CREB signaling. |
| 16207795 |
Results suggest that hypoxia promotes intestinal epithelial amphiregulin expression in a CREB-dependent manner, an event that may contribute to increased proliferation. |
| 12568494 |
Review. The activation of EGFR in response to smoke involves cleavage of amphiregulin by ADAM 17. |
| 16213893 |
The mechanism of deoxycholic acid-induced epideermal growth factor receptor activation is ligand-dependent and is controlled, at least in part, at the level of amphiregulin release from the basolateral cell membrane. |
| 17035230 |
Amphiregulin (AR) up-regulates a number of genes involved in cell motility and invasion in MCF10A cells, suggesting that an AR autocrine loop contributes to the aggressive breast cancer phenotype. |
| 15284208 |
AR is under strong regulation by the cAMP pathway in various cell types |
| 14633617 |
Amphiregulin(AR) overexpressing cells (HaCaT-AR) displayed autonomous proliferation in serum-free media. HaCaT-AR cells formed rapidly growing tumors with AR expression similar to keratoacanthoma. |
| 15955087 |
Enhanced transmigration of human neutrophils through polarized epithelial cell monolayers of MDCK cells after administration of AR, further supporting aspecific role for AR in pathogenesis of psoriasis. |
| 17548638 |
MIP-3alpha-mediated ERK1/2 activation in Caco-2 cells appeared to require metalloproteinase-dependent release of the endogenous EGFR ligand amphiregulin and transactivation of the EGFR. |
