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KCNA5
| Symbol: | KCNA5 | | Name(s): | potassium voltage-gated channel, shaker-related subfamily, member 5 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | HCK1, HK2, HPCN1, KV1.5, MGC117058, MGC117059, PCN1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18083891 |
mitochondrial abnormalities that disturb the reactive O(2) species HIF-1alpha-Kv1.5 O(2)-sensing pathway contribute to the pathogenesis of pulmonary arterial hypertension and cancer--REVIEW |
| 18209767 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18209767 |
R87Q and P307S polymorphisms in hKv1.5, possibly in combination with other risk factors, may influencethe development of postoperative atrial fibrillation |
| 17868645 |
In conclusion, N-cadherin modifies Kv1.5 channel activity and is thus a novel candidate signaling molecule participating in the regulation of a variety of functions including cardiac action potential and vascular tone. |
| 17344312 |
S-acylation can regulate steady-state expression of Kv1.5. |
| 16902793 |
Mg2+ block causes voltage-dependent inactivation of Kv1.5 |
| 15623896 |
This suggests that for Kv channels, the coupling between voltage sensing and gating reflects primarily an intrasubunit interaction. |
| 12850541 |
Kv1.5 potassium channel mRNA expression correlates with glioma entities and malignancy grades; expression is high in astrocytomas, moderate in oligodendrogliomas, and low in glioblastomas. |
| 15140747 |
Overexpression of the human KCNA5 gene increases K+ currents (i.e., K+ efflux or loss), accelerates apoptotic volume decrease (AVD), increases caspase-3 activity, and induces apoptosis |
| 16411137 |
We found three heterozygous SNPs: R87Q, A251T, and P307S. Both R87Q and P307S diminished the inactivation amplitude. | →View more information from publications. |
Recent Publications on KCNA5: |  |
Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells.
Acute hypoxia induces pulmonary vasoconstriction and chronic hypoxia... | 3rd November, 2009
| Department of Medicine, University of California, San Diego, La Jolla, CA
| Ann N Y Acad Sci. 2009 Oct;1177:101-11.
DOI Direct Link |
Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis.
BACKGROUND: The remodeled vessel wall in many vascular diseases such as... | 30th October, 2009
| Centre de Recherche de L'Hotel-Dieu de Quebec, 9 Rue McMahon, Quebec, Qc,
| Circulation. 2009 Sep 29;120(13):1231-40. Epub 2009 Sep 14.
DOI Direct Link |
Aging and muscle fiber type alter K+ channel contributions to the myogenic response in skeletal muscle arterioles.
Aging diminishes myogenic tone in arterioles from skeletal muscle. Recent... | 18th September, 2009
| Department of Physiology and Pharmacology, West Virginia University School
| J Appl Physiol. 2009 Aug;107(2):389-98. Epub 2009 Apr 30.
DOI Direct Link |
Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation.
Pharmacological management of atrial fibrillation (AF) remains an... | 25th August, 2009
| Masonic Medical
| J Electrocardiol. 2009 Nov-Dec;42(6):543-8. Epub 2009 Aug 20.
DOI Direct Link |
Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5.
Conventional antiarrhythmic drugs target the ion permeability of channels,... | 15th July, 2009
| Department of Pharmacology, 1301 MSRBIII, 1150 W Medical Center Dr, Ann
| Circ Res. 2009 Jun 19;104(12):1390-8. Epub 2009 May 14.
DOI Direct Link |
→View more research publications. |
KCNA5 results (if any) from reagent suppliers | 
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KCNA5 antibodies: Cardiovascular > Hypoxia > Hypoxia-Regulated | Abcam
KCNA5 antibodies. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab50294 · KCNA5 antibody. WB, ICC/IF. Rabbit polyclonal
...
http://www.abcam.com/index.html?t=203188&pt=1&c=335&ei=&mu=r...
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KV1.5 (H-120) Antibody sc-25681
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KCNA5, 3741, 12p13.32, NM_002234 ...
http://www.scbt.com/datasheet-25681-kv1-5-h-120-antibody.htm...
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Complete Solutions for Ion Channels
KCNA5, NM_002234, potassium voltage-gated channel: shaker-related subfamily: member 5, P9357. KCNA6, NM_013568, potassium voltage-gated channel: ...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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KV1.5 (H-120) Antibody sc-25681
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, KCNA5, 3741, 12p13.32, NM_002234 ...
http://www.scbt.com/ja/datasheet-25681-kv1-5-h-120-antibody....
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Abcam antibodies and reagents product map
... Angiotensin II Type 1 Receptor antibodies · Angiotensin III antibodies · Endothelin 1 antibodies · Endothelin 2 antibodies · KCNA5 antibodies ...
http://www.abcam.com/index.html?pageconfig=productmap&Cl=226...
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KV1.5 (H-120) Antibody sc-25681
... Numero de acesso de isoformas de RNA mensageiro, Numero de acesso de proteina, OMIM&trande; Numero. Humano, KCNA5, 3741, 12p13.32, NM_002234 · P22460
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http://www.scbt.com/pt/datasheet-25681-kv1-5-h-120-antibody....
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Abcam antibodies and reagents product map
... HCN2 + HCN4 antibodies (1) · HCN3 antibodies (4) · HCN4 antibodies (6) · HCN4 proteins and peptides (1) · KCNA5 antibodies (2) · KCNE1 antibodies (4) ...
http://www.abcam.com/index.html?c=253...
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