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KCNB1
| Symbol: | KCNB1 | | Name(s): | potassium voltage-gated channel, Shab-related subfamily, member 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DRK1, KV2.1, h-DRK1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15353504 |
There is a central role for developmentally regulated ductus arteriosus SMC O2-sensitive Kv channels in the functional closure of the DA. |
| 12560340 |
exposed residues in the T1 domain of the N terminus, as well as the CTA domain in the C terminus, are important in determining channel activation kinetics and that these N- and C-terminal regions interact |
| 12403834 |
SNAP-25 protein modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus. |
| 15827117 |
formation of heteromeric Kv2.1/Kv9.3 channels of fixed stoichiometry consisting of three Kv2.1 subunits and one Kv9.3 subunit |
| 12021261 |
characterization of Kv2.1 |
| 16880266 |
Results support a model whereby an outer vestibule lysine interferes with K+ flux through the channel, and that the [K+]-dependent change in orientation of this lysine alters single channel conductance by changing the level of this interference. |
| 15024041 |
direct functional interaction, which is modulated by permeant ions acting at the selectivity filter, between the outer vestibule of the Kv2.1 potassium channel and the voltage sensor. |
| 11852086 |
These results indicate that Kv6.3 is a novel member of the voltage-gated K(+) channel which functions as a modulatory subunit of the Kv2.1 channel. |
| 16008572 |
native Kv2.1 polypeptides are more abundantly found in brain |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | KCNB1 | potassium voltage-gated channel, subfamily G, member 1 | - | - | Pubmed |
| HPRD | KCNB1 | syntaxin 1A | - | - | Pubmed |
| HPRD | KCNB1 | protein tyrosine phosphatase, receptor type, E isoform 1 precursor | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, Shab-related subfamily, member 1 | KH2 | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, Shab-related subfamily, member 1 | Protein tyrosine phosphatase, receptor type, E | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, Shab-related subfamily, member 1 | Syntaxin 1A | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, Shab-related subfamily, member 1 | synaptosomal-associated protein 25 isoform SNAP25A | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, Shab-related subfamily, member 1 | synaptosomal-associated protein 25 isoform SNAP25A | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, Shab-related subfamily, member 1 | potassium voltage-gated channel, Shab-related subfamily, member 1 | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, Shab-related subfamily, member 1 | potassium voltage-gated channel, subfamily G, member 2 | - | - | Pubmed |
Recent Publications on KCNB1: |  |
Molecular diversity of deep short-axon cells of the rat main olfactory bulb.
Local circuit GABAergic interneurons comprise the most diverse cell... | 28th August, 2009
| Laboratory of Cellular Neurophysiology, Institute of Experimental
| Eur J Neurosci. 2009 Apr;29(7):1397-407.
DOI Direct Link |
Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons.
Silent voltage-gated K(+) (K(v)) subunits interact with K(v)2 subunits and... | 10th July, 2009
| Laboratory for Molecular Biophysics, Physiology and Pharmacology,
| Am J Physiol Cell Physiol. 2009 Jun;296(6):C1271-8. Epub 2009 Apr 8.
DOI Direct Link |
A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells.
We examined the ionic mechanisms mediating depolarization-induced spike... | 1st July, 2009
| Department of Medicine, University of Chicago, Chicago, Illinois, USA.
| Biophys J. 2009 Apr 22;96(8):3126-39.
DOI Direct Link |
Role of protein kinase C in 15-HETE-induced hypoxic pulmonary vasoconstriction.
The aim of the present study was to investigate the roles of protein... | 1st July, 2009
| Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin
| Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):115-23.
DOI Direct Link |
A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate.
BACKGROUND: Population isolates are characterized by simplified genetic... | 24th June, 2009
| Institute for Anthropological Research, Zagreb, Croatia.
| Am J Hypertens. 2009 Jun;22(6):663-8. Epub 2009 Mar 5.
DOI Direct Link |
→View more research publications. |
KCNB1 results (if any) from reagent suppliers | 
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Complete Solutions for Ion Channels
KCNB1, NM_008420, potassium voltage-gated channel: Shab-related subfamily: member 1, P9607. KCNC1, NM_004976, potassium voltage-gated channel: Shaw-related
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http://www.sigmaaldrich.com/life-science/functional-genomics...
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Anti-Kv2.1
20 Aug 2006 ... (DRK1, Kcnb1). Product #: APC-012. Current Lot ##: AN-02. Host: Rabbit. Type: Polyclonal. Epitope: (CY)HMLPGGGAHGSTRDQSI, corresponding to ...
http://www.alomone.com/system/UpLoadFiles/DGallery/Docs/APC-...
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KV2.1 (K-16) Antibody sc-22379
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, KCNB1, 3745, 20q13.13, NM_004975 ...
http://www.scbt.com/ja/datasheet-22379-kv2-1-k-16-antibody.h...
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B0753 2,3-Butanedione monoxime BDM reagent grade, ≥98%
grade, reagent grade. assay, ≥98%. bp, 185-186 °C(lit.) mp, 75-78 °C(lit.) Gene Information, human ... KCNB1(3745). Safety. Safety Statements, 22-24/25 ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=B075...
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KV Antibody / KV Antibodies
製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. KVβ.1 (C-13) 抗体, sc-51104, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, h, cow ...
http://www.scbt.com/ja/table-kv.html...
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eHandbook 001_050.indd
Kv2.1-2.2 (KCNB1-2),. Kir 3.1-3.4 (GIRK1-4;KCNJ 3, 6, 9, 5),. KCNK5 (TASK-2), KCNK6 (TWIK-2),. Kv3.1-3.4 (KCNC1-4),. Kir 4.1-4.2 (KCNJ 10, 15), ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/RBI_Hand...
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KV2.1 siRNA (h) sc-43885
种属, 基因名称, 基因ID, 染色质位置, 亚型（mRNA）即位号码, 蛋白质即位号码, OMIM™ 号码. 人类, KCNB1, 3745, 20q13.13, NM_004975 · Q14721 ...
http://www.scbt.com/zh/datasheet-43885-kv2-1-sirna-h.html...
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