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KCND3
| Symbol: | KCND3 | | Name(s): | potassium voltage-gated channel, Shal-related subfamily, member 3 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | KCND3L, KCND3S, KSHIVB, KV4.3, MGC142035, MGC142037 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15563876 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17725712 |
Kv4.3 regulates angiotensin type 1 receptor signaling to the small G-protein Rap-1 |
| 15890703 |
Co-expression of DPPX in addition to Kv4.3 and KChIP2a produced similar current kinetics as in human ventricular myocytes |
| 16782062 |
KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2 |
| 15563876 |
mutations in KCND2 and KCND3 are not a frequent cause of long QT syndrome |
| 12297301 |
Kv4.3 promiscuously assembles with ancillary subunits in vitro, functionally modifying the encoded currents. |
| 14645239 |
the two arginines in the cytosolic C-terminal domain of alpha-subunits of Kv4 subfamily strongly regulate the voltage dependence of channel activation, inactivation, and recovery |
| 15498806 |
Both Kv4.3 and KChIP2 may contribute to epicardial-endocardial gradients in the transient outward current in normal and failing hearts. |
| 12928444 |
Analysis with chimeric proteins between KChIP2 and NCS-1 reveals that the three regions of KChIP2 are necessary and sufficient for its effective binding to Kv4.3 protein |
| 17506992 |
the mechanisms involved in Syn1A-K(v) interactions vary significantly between K(v) channels, thus providing a wide scope for Syn1A modulation of exocytosis and membrane excitability | →View more information from publications. |
Recent Publications on KCND3: |  |
Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome.
INTRODUCTION: The Brugada Syndrome (BrS), an inherited syndrome associated... | 29th October, 2009
| Department of Pharmacology, School of Medicine, Universidad Complutense,
| Circ Arrhythm Electrophysiol. 2008 Aug;1(3):209-18.
DOI Direct Link |
Divergent regulation of cardiac KCND3 potassium channel expression by the thyroid hormone receptors alpha1 and beta1.
The cardiac transient outward current I(to) is regulated by thyroid... | 12th May, 2009
| Department of Internal Medicine III, University of Cologne, Kerpener Str.
| J Physiol. 2009 Mar 15;587(Pt 6):1319-29. Epub 2009 Jan 26.
DOI Direct Link |
Mutation analysis of candidate genes SCN1B, KCND3 and ANK2 in patients with clinical diagnosis of long QT syndrome.
The long QT syndrome (LQTS) is a monogenic disorder characterized by... | 6th March, 2009
| Department of Genetics and Molecular Biology, Faculty of Science, Masaryk
| Physiol Res. 2008;57(6):857-62. Epub 2007 Nov 30.
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Strategy for a genetic assessment of antipsychotic and antidepressant-related proarrhythmia.
Antidepressants and antipsychotics may affect several ion channels... | 1st November, 2008
| Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli, 5,
| Curr Med Chem. 2008;15(24):2472-517.
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Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventricles.
Accumulated evidence suggests that the heteromeric assembly of Kv4.2 and... | 7th March, 2008
| Department of Molecular Biology and Pharmacology, Washington University
| J Mol Cell Cardiol. 2008 Jan;44(1):95-104. Epub 2007 Oct 18.
DOI Direct Link |
→View more research publications. |
KCND3 results (if any) from reagent suppliers | 
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KV4.3 (N-15) Antibody sc-11684
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KCND3, 3752, 1p13.2, NM_004980, ...
http://www.scbt.com/datasheet-11684-kv4-3-n-15-antibody.html...
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Complete Solutions for Ion Channels
KCND3, NM_004980, potassium voltage-gated channel: Shal-related subfamily: member 3, P0358. KCNQ1, NM_000218, potassium voltage-gated channel: KQT-like ...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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KV4.3 (N-15) Antibody sc-11684
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, KCND3, 3752, 1p13.2, NM_004980, ...
http://www.scbt.com/ja/datasheet-11684-kv4-3-n-15-antibody.h...
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KV4.3 (C-17) Antibody sc-11686
Humano, KCND3, 3752, 1p13.2, NM_004980, NM_172198 · Q9UK17 · 605411. Ratón, Kcnd3, 56543, 3 F2.2, Q9Z0V1, No Aplicable ...
http://www.scbt.com/es/datasheet-11686-kv4-3-c-17-antibody.h...
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