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KCNE1


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Symbol:KCNE1
Name(s):potassium voltage-gated channel, Isk-related family, member 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:ISK, JLNS, JLNS2, LQT5, MGC33114, MinK
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18079560 KCNE peptides differently modulate the voltage sensor in KCNQ1 K(+) channels.
17905336 Observational study of genotype prevalence. (HuGE Navigator)
11289718 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
12228786 Observational study of gene-disease association. (HuGE Navigator)
14661677 Observational study of gene-disease association. (HuGE Navigator)
14760488 Observational study of gene-disease association. (HuGE Navigator)
15051636 Observational study of gene-disease association. (HuGE Navigator)
15176425 Observational study of genotype prevalence. (HuGE Navigator)
15746444 Observational study of gene-disease association. (HuGE Navigator)
15840476 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDPotassium channel, voltage gated, ISK related subfamily, member 1potassium voltage-gated channel, KQT-like subfamily precursor, member 1--Pubmed
HPRDPotassium channel, voltage gated, ISK related subfamily, member 1voltage-gated potassium channel, subfamily H, member 2 isoform a--Pubmed

Recent Publications on KCNE1:

Pubmed Logo
Detailed molecular and clinical characterization of three patients with 21q deletions.
Lindstrand A, Malmgren H, Sahlen S, Schoumans J, Nordgren A, Ergander U,...
30th October, 2009
Department of Molecular Medicine and Surgery, Clinical Genetics Unit, Clin Genet. 2009 Oct 23.
DOI Direct Link
Thyroid hormone receptor alpha can control action potential duration in mouse ventricular myocytes through the KCNE1 ion channel subunit.
Abstract Aims: The reduced heart rate and prolonged QT(end) duration in...
17th October, 2009
Department of Cell and Molecular Biology, Karolinska Institute, S-171 77 Acta Physiol (Oxf). 2009 Oct 14.
DOI Direct Link
D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome.
OBJECTIVES: This study aims to address whether D85N, a KCNE1 polymorphism,...
9th October, 2009
Department of Cardiovascular Medicine, Kyoto University Graduate School of J Am Coll Cardiol. 2009 Aug 25;54(9):812-9.
DOI Direct Link
Long QT syndrome-associated mutations in the voltage sensor of I(Ks) channels.
The plateau phase of the ventricular action potential is the result of...
6th October, 2009
Department of Physiology I, University of Tuebingen, Tuebingen, Germany. Cell Physiol Biochem. 2009;24(1-2):11-6. Epub 2009 Jul 1.
DOI Direct Link
Positive selection at codon 38 of the human KCNE1 (= minK) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes.
BACKGROUND: KCNE1 represents the regulatory beta-subunit of the slowly...
1st October, 2009
Institute of Anthropology, Johannes Gutenberg University, Mainz 55099, BMC Evol Biol. 2009 Aug 6;9:188.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6403360 KCNQ potassium channels and methods of modulating same
6844355 Optically active isomers of quinine and quinidine and their respective biological action
6864364 MinK-related genes, formation of potassium channels and association with cardiac arrhythmia
6972176 KVLQT1--a long QT syndrome gene
7034008 Cardiac arrhythmia treatment methods

View more patents.

KCNE1 results (if any) from reagent suppliers

Google CSE Logo
KCNE1 antibody (ab55274) | Abcam
Mouse monoclonal to KCNE1. KCNE1 (Potassium voltage-gated channel subfamily E member 1) is an ancillary protein that assembles as a beta subunit with a ...
http://www.abcam.com/KCNE1-antibody-ab55274.html...

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KCNE1 Antibody #3486
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide (KLH-coupled) corresponding to residues surrounding Asp76 of human KCNE1
...
http://www.cellsignal.com/products/3486.html...

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KCNE1 monoclonal antibody (M01)
KCNE1 (NP_000210, 67 a.a. ~ 130 a.a) partial recombinant protein with GST tag. ... Western blot analysis of KCNE1 over-expressed 293 cell line, ...
http://www.abgent.com/products/catalog_no/AT2592a_KCNE1_mono...

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KCNE1 Antibody
KCNE1, also known as MinK, belongs to a family of small transmembrane proteins ( KCNE1, -2, -3, ... inherited mutations in KCNE1 result in long QT syndrome ...
http://www.cellsignal.com/pdf/3486.pdf...

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KCNE1 antibodies: Neuroscience > Neurotransmission > Receptors ...
KCNE1 antibodies. ... KCNE1 antibody. WB, I-ELISA. Rabbit polyclonal. Reacts with: Hu. ab65795 · KCNE1 antibody. IHC-P, WB. Rabbit polyclonal. Reacts with:
...
http://www.abcam.com/index.html?t=226987&pt=1&c=392&ei=&mu=r...

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KCNE1 siRNA (m) sc-42500
Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: KCNE1 (m)-PR: sc-42500-PR, 20 µl ...
http://www.scbt.com/datasheet-42500-kcne1-sirna-m.html...

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K+ Channels in Cardiomyocytes
other channel proteins (KCNE1 and KV7.1) in horse atria and ventricles.12 Anti- Kir ..... APC-122. Antibodies to K+ Channels Auxiliary Subunits. Anti-KCNE1 ...
http://www.alomone.com/system/UpLoadFiles/DGallery/Docs/K%20...

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