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KCNH1
| Symbol: | KCNH1 | | Name(s): | potassium voltage-gated channel, subfamily H (eag-related), member 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | EAG, EAG1, Kv10.1, MGC142269, h-eag | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17873312 |
Eag1 is aberrantly expressed in gastric cancer tissues and cell lines and associated with cancer lymph node metastasis and stage and play an important role in the proliferation of gastric cancer cells. |
| 17520698 |
IGF-1 regulates ether-a-go-go channel activity in breast neoplasms, via an Akt pathway to promote cell proliferation. |
| 15466192 |
EAG channel activity in human tumors is shown for the first time. |
| 17022811 |
High frequency of expression of Eag1 in primary tumours and the restriction of normal expression of the channel to the brain, suggests the application of this protein for diagnostic or therapeutic purposes. |
| 17360457 |
analysis of KCNQ potassium channel mutations that cause cardiac arrhythmias in Drosophila, mimicing the effects of aging |
| 17451210 |
Eag1 protein and mRNA are aberrantly expressed in colorectal cancer and occasionally expressed in colorectal adenoma. |
| 11834728 |
Regulation of an ERG K+ current by Src tyrosine kinase. |
| 16478480 |
identified three putative CaM-binding domains, two in the C-terminus (BD-C1: 674-683, BD-C2: 711-721) and one in the N-terminus (BD-N: 151-165) |
| 15548764 |
Compounds like RPR260243 will be useful for studying the physiological role of HERG and may one day find use in treating cardiac disease. |
| 16537547 |
It was shown that short interfering RNA sequences act specifically on EagI, reproducibly induce a significant decrease in the proliferation of tumor cell lines, and do not trigger any observable nonspecific responses. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | potassium voltage-gated channel, subfamily F, member 1 | potassium voltage-gated channel, subfamily H, member 1 isoform 1 | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, subfamily F, member 1 | potassium voltage-gated channel, subfamily H, member 1 isoform 1 | - | - | Pubmed |
| HPRD | Potassium channel voltage gated, subfamily H, member 1 | alpha2-glucosyltransferase | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, subfamily H, member 1 isoform 1 | Potassium channel regulator 1 | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, subfamily H, member 1 isoform 1 | potassium voltage-gated channel, subfamily H, member 5 isoform 1 | - | - | Pubmed |
| HPRD | potassium voltage-gated channel, subfamily H, member 1 isoform 1 | potassium voltage-gated channel, subfamily H, member 5 isoform 1 | - | - | Pubmed |
Recent Publications on KCNH1: |  |
Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists.
We have designed and synthesized a novel series of pyrrolidinones as... | 14th October, 2009
| Department of Chemistry, Metabolic Pathways Centre for Excellence in Drug
| Bioorg Med Chem Lett. 2009 Aug 15;19(16):4664-8. Epub 2009 Jun 25.
DOI Direct Link |
Synthesis and biological evaluation of imidazole derivatives as novel NOP/ORL1 receptor antagonists: exploration and optimization of alternative pyrazole structure.
Nonpeptidic small-molecule NOP/ORL1 receptor antagonists with an imidazole... | 14th October, 2009
| Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Tsukuba
| Bioorg Med Chem Lett. 2009 Aug 15;19(16):4611-6. Epub 2009 Jul 1.
DOI Direct Link |
Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists.
A novel series of cyclohexanamine derivatives was designed and synthesized... | 14th October, 2009
| Tsukuba Research Institute, Merck Research Laboratories, Banyu
| Bioorg Med Chem Lett. 2009 Aug 15;19(16):4781-5. Epub 2009 Jun 17.
DOI Direct Link |
Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification.
The synthesis and SAR of a new series of potent and selective dopamine... | 14th October, 2009
| Cancer Therapeutics, Melbourne, Australia.
| Bioorg Med Chem Lett. 2009 Aug 15;19(16):4799-801. Epub 2009 Jun 14.
DOI Direct Link |
Loss of functional K+ channels encoded by ether-a-go-go-related genes in mouse myometrium prior to labour onset.
There is a growing appreciation that ion channels encoded by the... | 4th September, 2009
| Division of Basic Medical Sciences, Ion Channels And Cell Signaling
| J Physiol. 2009 May 15;587(Pt 10):2313-26. Epub 2009 Mar 30.
DOI Direct Link |
→View more research publications. |
KCNH1 results (if any) from reagent suppliers | 
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KCNH Antibody / KCNH Antibodies
KCNH1 shRNA Plasmid (m): sc-146362-SH. KCNH1 shRNA (m) Lentiviral Particles: sc- 146362-V. KCNH3 siRNA (h): sc-95657. KCNH3 shRNA Plasmid (h): sc-95657-SH ...
http://www.scbt.com/table-kcnh.html...
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P0999 Anti-Potassium Channel Kv10.1 (EAG-1) antibody produced in ...
Synonym: Anti-Ether-a-go-go K+ channel 1, Anti-KCNH1 ... rat ... Kcnh1(65198). mouse ... Kcnh1(16510). shipped in, wet ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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KCNH1 siRNA (m) sc-146362
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: KCNH1 ...
http://www.scbt.com/ja/datasheet-146362-kcnh1-sirna-m.html...
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P0999dat Anti-Potassium Channel Kv10.1 MCT,PHC 10-05-1
channel 1; Anti-KCNH1) produced in rabbit, affinity isolated antibody. Product Number P0999. Product Description. Anti-Potassium Channel KV10.1 was ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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Abcam antibodies and reagents product map
... KCNE2 antibodies (3) · KCNE3 antibodies (1) · KCNE4 antibodies (1) · KCNF1 antibodies (1) · KCNG1 antibodies (2) · KCNH1 antibodies (1) ...
http://www.abcam.com/index.html?cl=248&pageconfig=productmap...
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Complete Solutions for Ion Channels
KCNH1, NM_002238, potassium voltage-gated channel: subfamily H (eag-related): member 1, P0999. KCR1, XM_047770, modifier of the HERG potassium channel ...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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K1003 Ketoconazole ≥98% (TLC)
ABCB1(5243), CYP11B1(1584), CYP11B2(1585), CYP17A1(1586), CYP19A1(1588), CYP1A2( 1544), CYP24A1(1591), CYP26A1(1592), CYP3A4(1576), CYP51A1(1595), KCNH1(3756 ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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