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KCNH2
| Symbol: | KCNH2 | | Name(s): | potassium voltage-gated channel, subfamily H (eag-related), member 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18162604 |
The differential sensitivity of hERG1 and rERG3 channels to the agonist effect of RPR could be accounted for by a single S5 residue (Thr556 in hERG1, Ile558 in rERG3). |
| 18222980 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18096051 |
Functional expression in CHO-K1 stable cell line improved with lowering temperature of the culturing environment |
| 18209470 |
hERG1 activation involves a cooperative conformational change involving the entire voltage sensing module, while inactivation may involve a more limited interaction between R531 and D456, D460 and D509. |
| 18191158 |
Inhibition of HERG currents may contribute to the arrhythmogenic side effects of protriptyline. |
| 11136691 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11289718 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 11743032 |
Observational study of gene-disease association, genetic testing, and healthcare-related. (HuGE Navigator) |
| 11997281 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 12142119 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Potassium channel, voltage gated, ISK related subfamily, member 1 | voltage-gated potassium channel, subfamily H, member 2 isoform a | - | - | Pubmed |
| HPRD | Potassium channel, voltage gated subfamily H, member 2 | alpha2-glucosyltransferase | - | - | Pubmed |
| HPRD | Potassium channel, voltage gated subfamily H, member 2 | tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptide | - | - | Pubmed |
| HPRD | Potassium channel, voltage gated subfamily H, member 2 | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide | - | - | Pubmed |
| HPRD | Potassium channel, voltage gated subfamily H, member 2 | potassium voltage-gated channel, Isk-related family, member 2 | - | - | Pubmed |
| HPRD | voltage-gated potassium channel, subfamily H, member 2 isoform a | Potassium channel, voltage gated, ISK related subfamily, member 2 | - | - | Pubmed |
| HPRD | voltage-gated potassium channel, subfamily H, member 2 isoform a | 14-3-3 epsilon | - | - | Pubmed |
| HPRD | voltage-gated potassium channel, subfamily H, member 2 isoform a | 14-3-3 Eta | - | - | Pubmed |
| HPRD | voltage-gated potassium channel, subfamily H, member 2 isoform a | Potassium channel regulator 1 | - | - | Pubmed |
| HPRD | voltage-gated potassium channel, subfamily H, member 2 isoform a | asparagine-linked glycosylation 10 homolog B | - | - | Pubmed |
Recent Publications on KCNH2: |  |
Sudden death: ethical and legal problems of post-mortem forensic genetic testing for hereditary cardiac diseases.
Elger BS, Michaud K, Fellmann F, Mangin P. Sudden death: ethical and legal... | 30th October, 2009
| Institut universitaire de medecine legale, Unite de droit medical et
| Clin Genet. 2009 Oct 23.
DOI Direct Link |
Regulation of HERG (KCNH2) potassium channel surface expression by diacylglycerol.
The HERG (KCNH2) channel is a voltage-sensitive potassium channel mainly... | 28th October, 2009
| Department of Biology, Abo Akademi University, 20520, Turku, Finland.
| Cell Mol Life Sci. 2009 Oct 27.
DOI Direct Link |
Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome.
BACKGROUND: Drugs with I(Kr)-blocking action cause secondary long-QT... | 22nd October, 2009
| Department of Cardiovascular and Respiratory Medicine, Shiga University of
| Circ Arrhythm Electrophysiol. 2009 Oct;2(5):511-23. Epub 2009 Aug 2.
DOI Direct Link |
Genetic Testing for Long-QT Syndrome: Distinguishing Pathogenic Mutations From Benign Variants.
BACKGROUND: Genetic testing for long-QT syndrome (LQTS) has diagnostic,... | 21st October, 2009
| Director, Long QT Syndrome Clinic and the Mayo Clinic Windland Smith Rice
| Circulation. 2009 Nov 3;120(18):1752-1760. Epub 2009 Oct 19.
DOI Direct Link |
D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome.
OBJECTIVES: This study aims to address whether D85N, a KCNE1 polymorphism,... | 9th October, 2009
| Department of Cardiovascular Medicine, Kyoto University Graduate School of
| J Am Coll Cardiol. 2009 Aug 25;54(9):812-9.
DOI Direct Link |
→View more research publications. |
KCNH2 results (if any) from reagent suppliers | 
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HERG (H-175) Antibody sc-20130
Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr). Am J Physiol Heart Circ Physiol. . 290: H1278-H1288. ...
http://www.scbt.com/datasheet-20130-herg-h-175-antibody.html...
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Anti-Potassium Channel KV11.1 Extracellular antibody produced in ...
(Anti-HERG; Anti-KCNH2) produced in rabbit, affinity isolated antibody. Product Number P0749. Product Description. Anti-Potassium Channel KV11.1 ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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HERG (N-20) Antibody sc-15966
Human, KCNH2, 3757, 7q36.1, NM_000238, NM_172056, NM_172057 · Q12809 · 609620. Mouse, Kcnh2, 16511, 5 A3, O35219, N/A. Ordering Information ...
http://www.scbt.com/datasheet-15966-herg-n-20-antibody.html...
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KCNE1 antibody (ab55274) | Abcam
KCNE1 assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). ...
http://www.abcam.com/KCNE1-antibody-ab55274.html...
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HERG (N-20) Antibody sc-15966
Human, KCNH2, 3757, 7q36.1, NM_000238, NM_172056, NM_172057 · Q12809 · 609620. Mouse, Kcnh2, 16511, 5 A3, O35219, 없음. 주문정보 ...
http://www.scbt.com/ko/datasheet-15966-herg-n-20-antibody.ht...
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Complete Solutions for Ion Channels
KCNH2, NM_000238, potassium voltage-gated channel: subfamily H (eag-related): member 2, P4996. KCNH1, NM_002238, potassium voltage-gated channel: subfamily
...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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Anti-Kv11.1 extracellular APC-109
19 Jan 2006 ... (Voltage gated K+ channel subfamily H member 2, KCNH2, ether-a-go-go-related channel 1). Product #: APC-109. Current Lot #: AN-03 ...
http://www.alomone.com/system/UpLoadFiles/DGallery/Docs/APC-...
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